Abstract
The effect of concentrated antibiotics on the healing rate of epithelial erosions in rabbit was measured by serial standardized photography. Histological studies were also performed.
Our results suggest that Kanamycin 30 mg/ml (p<0.001), Penicillin 100,000 units/ml (p<0.001) and Vancomycin 31 mg/ml (p<0.01) administered six times a day retard the epithelial wound healing compared with control animals which received isotonic NaCl.
Similar content being viewed by others
References
Dolhman, C.H. The function of the corneal epithelium in health and disease. Invest. Ophthalmol. 10: 383–407 (1971).
Burstein, N.L. Corneal cytotoxicity of topically applied drugs, vehicles and preservatives. Surv. Ophthalmol. 25: 15–30 (1980).
Moses, R., G. Parkinson & R. Schuchardt. A standard large wound of the corneal epithelium in the rabbit. Invest. Ophthalmol. 18: 103–106 (1970).
Grayson, M. Disease of the cornea. C.V. Mosby, St. Louis, p. 53 (1979).
Petroutsos, G., R. Guimaraes, J.P. Giraud & Y. Pouliquen. Antibiotics and corneal epithelial wound healing. Arch. Ophthalmol. 101: 1775–1778 (1983).
Zimmerman, M.C. The prophylaxis and treatment of penicillin reactions with penicillinase. Clin. Med. 5: 305–311 (1958).
Moses, W.G., R. Wood & M. Stock. Effect of some agents on regeneration of corneal epithelium. Am. J. Ophthalmol. 34: 609–612 (1951).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Petroutsos, G., Guimaraes, R. & Pouliquen, Y. The effect of concentrated antibiotics on the rabbit's corneal epithelium. Int Ophthalmol 7, 65–69 (1984). https://doi.org/10.1007/BF00165106
Issue Date:
DOI: https://doi.org/10.1007/BF00165106