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Nuclear pores in the apoptotic cell

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Summary

During apoptosis, nuclear pores undergo strong modifications, which are described here in five different apoptotic models. Conventional electron microscopy, supported by freeze-fracture analysis, showed a constant migration of nuclear pores towards the diffuse chromatin areas. In contrast, dense chromatin areas appear pore-free and are frequently surrounded by strongly dilated cisternae. A possible functional significance of this pore behaviour during apoptosis is discussed.

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Author notes

  1. Marco Vitale

    Present address: Jefferson Cancer Inst., Bluemle Life Sciences Building, Thomas Jefferson University, 19107, Philadelphia, PA, USA

Authors and Affiliations

  1. Istituto di Morfologia Umana Normale, Università di Chieti, Italy

    Elisabetta Falcieri & Amelia Cataldi

  2. Istituto di Citomorfologia Normale e Patologica CNR, c/o Ist. Codivilla-Putti, Bologna, Italy

    Elisabetta Falcieri & Marco Vitale

  3. Istituto di Anatomia Umana Normale, Università di Bologna, Bologna, Italy

    Pietro Gobbi & Loris Zamai

  4. Lab. Biol. Cell. Microsc. Elettr., c/o Ist. Ortopedico Rizzoli, Bologna, Italy

    Irene Faenza

  5. Dipartimento di Scienze Biomediche e Biotecnologie, Sez. Anatomia Umana, Università di Brescia, Brescia, Italy

    Marco Vitale

Authors
  1. Elisabetta Falcieri
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  2. Pietro Gobbi
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Falcieri, E., Gobbi, P., Cataldi, A. et al. Nuclear pores in the apoptotic cell. Histochem J 26, 754–763 (1994). https://doi.org/10.1007/BF00158206

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  • DOI: https://doi.org/10.1007/BF00158206

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