Skip to main content
SpringerLink
Log in

Experimental retinal tolerance to very low viscosity silicone oil (100 cs) as a vitreous substitute compared to higher viscosity silicone oil (5000 cs)

  • Articles
  • Published:
International Ophthalmology Aims and scope Submit manuscript

Abstract

We evaluated the toxicity of very low viscosity (100 centistokes) and higher viscosity silicone oil (5000 centistokes) in rabbit eyes as a short-to-long-term postoperative vitreous substitute (6 weeks to 5 months). Emulsification of 100-cs and 5000-cs silicone oil did not occur in eyes which were followed for as long as 5 months. No toxic effects to retinal cells were detected by light or electron microscopy. Because no toxic effects were seen with 100-cs silicone oil, it can be used in an outpatient setting as a short-term postoperative tamponading agent. Electroretinographic responses of silicone-injected eyes were normal.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Gonvers M, Hornung JP, de Courten C. The effect of liquid silicone on the rabbit retina: histologic and ultrastructural study. Arch Ophthalmol 1986; 104: 1057-62.

    Google Scholar 

  2. Lee PF, Donovan RH, Mukai N, Schepens CL, Freeman HM. Intravitreous injection of silicone: an experimental study. I. Clinical picture and histology of the eye. Ann Ophthalmol 1969; 1 (2): 15–25.

    Google Scholar 

  3. Mukai N, Lee PF, Schepens CL. Intravitreous injection of silicone: An experimental study. II. Histochemistry and electron microscopy. Ann Ophthalmol 1972; 4: 273–87.

    Google Scholar 

  4. Mukai N, Lee PF, Oguri M, Schepens CL. A long-term evaluation of silicone retinopathy in monkeys. Can J Ophthalmol 1975; 10: 391–402.

    Google Scholar 

  5. Stone W Jr. Alloplasty in surgery of the eye. N Engl J Med 1958; 258: 486–90.

    Google Scholar 

  6. Armaly MF. Ocular tolerance to silicone. Replacement of aqueous and vitreous by silicone fluids. Arch Ophthalmol 1962; 68: 390–5.

    Google Scholar 

  7. Levine AM, Ellis RA. Intraocular liquid silicone implants. Am J Ophthalmol 1963; 55: 939–43.

    Google Scholar 

  8. Labelle P, Okun E. Ocular tolerance to liquid silicone: an experimental study. Can J Ophthalmol 1972;7: 199–204.

    Google Scholar 

  9. Ober RR, Blanks JC, Ogden TE, Pickford M, Minckler DS, Ryan SJ. Experimental retinal tolerance to liquid silicone. Retina 1983; 3: 77–84.

    Google Scholar 

  10. Suzuki M, Okada T, Takeuchi S, Ishii Y, Yamashita H, Hori S. Effect of silicone oil on ocular tissues. Jpn J Ophthalmol 1991; 35: 282–91.

    Google Scholar 

  11. Pastor JC, Lopez MS, Saornil MI, Refojo MF. Intravitreal silicone and fluorosilicone oils. Pathologic findings in rabbit eyes. Acta Ophthalmologica 1992; 70: 651–8.

    Google Scholar 

  12. Thresher RJ, Ehrenberg M, Machemer R. Gas-mediated vitreous compression: an experimental alternative to mechanized vitrectomy. Graefes Arch Clin Exp Ophthalmol 1984; 221: 192–8.

    Google Scholar 

  13. Cibis PA, Becker B, Okun E, Canaan S. The use of liquid silicone in retinal detachment surgery. Arch Ophthalmol 1962; 68: 590–9.

    Google Scholar 

  14. Leaver PK, Lean JS. Management of giant retinal tears using vitrectomy and silicone oil/fluid exchange: a preliminary report. Trans Ophthalmol Soc UK 1981; 101: 189–91.

    Google Scholar 

  15. Lean JS, Leaver PK, Cooling RJ, McLeod D. Management of complex retinal detachments by vitrectomy and fluid/silicone exchange. Trans Ophthalmol Soc UK 1982; 102: 203–5.

    Google Scholar 

  16. McLeod D. Silicone-oil injection during closed microsurgery for diabetic retinal detachment. Graefes Arch Clin Exp Ophthalmol 1986; 224: 55–9.

    Google Scholar 

  17. Silicone Study Group. Vitrectomy with silicone oil or sulfur hexafluoride gas in eyes with severe proliferative vitreoretinopathy: results of a randomized clinical trial. Silicone study report 1. Arch Ophthalmol 1992; 110: 770–9.

    Google Scholar 

  18. Silicone Study Group. Vitrectomy with silicone oil or perfluoropropane gas in eyes with severe proliferative vitreoretinopathy: results of a randomized clinical trial. Silicone study group report 2. Arch Ophthalmol 1992; 110: 780–92.

    Google Scholar 

  19. Thaler A, Lessel MR, Gnad H, Heilig P. The influence of intravitreously injected silicone oil on electrophysiological potentials of the eye. Doc Ophthalmol 1986; 62: 41–6.

    Google Scholar 

  20. Foerster MH, Esser J, Laqua H. Silicone oil and its influence on electrophysiologic findings. Am J Ophthalmol 1985; 99: 201–6.

    Google Scholar 

  21. Momirov D, van Lith GHM, Zivojnovic R. Electroretinogram and electrooculogram of eyes with intravitreously injected silicone oil. Ophthalmologica 1983; 186: 183–8.

    Google Scholar 

  22. Crisp A, de Juan E Jr, Tiedeman J. Effect of silicone oil viscosity on emulsification. Arch Ophthalmol 1987; 105: 546–50.

    Google Scholar 

  23. Heidenkummer HP, Kampik A, Thierfelder S. Emulsification of silicone oils with specific physicochemical characteristics. Graefes Arch Clin Exp Ophthalmol 1991; 229: 88–94.

    Google Scholar 

  24. Heidenkummer HP, Kampik A, Thierfelder S. Experimental evaluation of in vitro stability of purified polydimethylsiloxanes (silicone oil) in viscosity ranges from 1000 to 5000 centistokes. Retina 1992; 12 (3): S28-S32.

    Google Scholar 

  25. Hutton WL, Fuller DG. Silicone oil in treatment of retinal disease. Ophthalmol Clin North America 1994; 7 (1): 89–99.

    Google Scholar 

  26. De Juan E Jr, McCuen B, Tiedeman J. Intraocular tamponade and surface tension. Surv Ophthalmol 1985; 30: 47–51.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. LSU Eye Center, Louisiana State University Medical Center School of Medicine, New Orleans, LA, USA

    Masoud Soheilian, Gholam A. Peyman, Takeshi Moritera & Hussein Wafapoor

Authors
  1. Masoud Soheilian
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Gholam A. Peyman
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Takeshi Moritera
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Hussein Wafapoor
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Soheilian, M., Peyman, G.A., Moritera, T. et al. Experimental retinal tolerance to very low viscosity silicone oil (100 cs) as a vitreous substitute compared to higher viscosity silicone oil (5000 cs). Int Ophthalmol 19, 57–61 (1995). https://doi.org/10.1007/BF00156421

Download citation

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00156421

Key words

Search

Navigation