Summary
Toxicity of organic solvents for in situ solvent extraction of carboxylic acids from aqueous solutions was studied on bacteria Bacillus subtillis and Acetobacter spp., yeasts Kluyveromyces marxianus and Pichia fermentans and fungi Aspergillus terreus and Rhizopus arrhizus. It has been found that trialkylamine and tributylphosphate are much more toxic than other carriers as trialkylphosphineoxide, triisobutylphosphinesulfide and trihexylphosphate. For R. arrhizus trihexylphosphate was found to be the less toxic solvent.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Bar, R., Gainer, J. L., Biotechnology Progress (1987), 3, 109–114.
Hartmeier, W., Herrfurth, S., Hembach, T., Kempker, R. (1990), Immobilised and Extractive Systems to Produce Lactic Acid. In: W. E. L. Spiess, H. Schubert (eds.), Engineering and Food, Vol. 3: Advanced Processes, London, Elsevier Applied Science, p. 496–505.
Honda, H., Taya, M., Kobayashi, T. (1986), J. Chem. Eng. Japan, 19, 268
Kaimakchiev, A., Denchev, D. (1991), Acta Microbiologica Bulgarica, 27, 40–45.
Krištofíková, L., Rosenberg, M., Vlnová, A., Šajbidor, J., Čertík, M. (1991), Folia Microbiologica, 6, 451–455.
Marták, J., Rosenberg, M., Schlosser, Š. (1994a), Influence of Organic Solvent Toxicity on Fungal Fermentation of Organic Acids, In: IUMS Congresses, 7th International Congress of Bacteriology and Applied Microbiology Division, 7th International Congress of Mycology Division, Abstract Book, Prague, p.394.
Marták, J., Rosenberg, M., Schlosser, Š., Krištofíková, E. (1994b), Toxicity of Organic Solvents in Fungal Fermentation of Lactic Acid (in Slovak), In: Proceedings of 21st Conference of Slovak Chemical Engineering Society, Vyhne, Slovakia, 83–86.
Miller, G. L. (1959), Analytical Chemistry, 31, 426–428.
Minier, M., Goma, G. (1982), Biotechnology and Bioengineering, 24, 1565–1579.
Park, Y. S., Chang, H. M., Kim, B. H. (1988), Biotechnology Letters, 10, 261–266.
Playne, M. J., Smith, B. R. (1983), Biotechnology and Bioengineering, 25, 1251–1265.
Polonský, J., Repášová, E., Pekarovičová, A., Košík, M. (1985), Journal of Chromatography, 320, 111–118.
Roffler, S. R., Randolph, T. W., Miller, D. A., Blanch, H. W., Prausnitz, J. M. (1991), Extractive Bioconversions with Nonaqueous Solvents, In: Mattiason, B., Holst, O. (Eds.), Extractive Bioconversions, New York, Marcel Dekker Inc., 135–140.
Schügerl, K. (1994), Solvent Extraction in Biotechnology, Berlin, Springer Verlag.
Šottník, B. (1992), Pertraction of Carboxylic Acids from Model Fermentation Solutions (in Slovak), MSc. Thesis, Slovak Technical University, Bratislava.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Marták, J., Rosenberg, M., Schlosser, Š. et al. Toxicity of organic solvents used in situ in microbial fermentation. Biotechnol Tech 9, 247–252 (1995). https://doi.org/10.1007/BF00151570
Issue Date:
DOI: https://doi.org/10.1007/BF00151570