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Immunocytochemistry of intracranial meningiomas

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Summary

Fifty meningiomas of four major histological types have been examined by immunocytochemical methods applied to formalin fixed paraffin embedded material and using readily available commercial antisera. The expression of GFAP, S100, NSE, vimentin, cytokeratin, fibronectin and desmoplakin was investigated. The majority of tumours contained NSE (86%) and S100 (78%), and all irrespective of histological type, contained vimentin and fibronectin. The epithelial marker cytokeratin was found in 56% of cases, but showed only focal expression. The relevance of these findings to histogenesis and metabolism is discussed and it is suggested that intermediate filament typing provides valuable information on meningiomas structure and function. The possible role of NSE and 5100 in meningeal neoplasm is discussed.

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  1. Brain Tumour Laboratory, Department of Neurosurgery, University of Birmingham, Midland Centre for Neurosurgery and Neurology, Holly Lane, Birmingham, Canada

    Edward Hitchcock & Christine S. Morris

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  1. Edward Hitchcock
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  2. Christine S. Morris
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Hitchcock, E., Morris, C.S. Immunocytochemistry of intracranial meningiomas. J Neuro-Oncol 5, 357–368 (1987). https://doi.org/10.1007/BF00148393

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