Skip to main content
Log in

Heredity of asthma in Saudi population

  • Published:
European Journal of Epidemiology Aims and scope Submit manuscript

Abstract

In a cross-sectional study, the prevalence of asthma, hay fever and eczema was studied in 1150 schoolchildren attending school in Jeddah Western region of Saudi Arabia. The family histories of asthma, hay fever and eczema were examined in first degree relatives. The age range of children studied was 7–12 years, with a mean of 9.3 years (47% boys and 53% girls). A self-administered questionnaire was completed by the parents of the child to collect information concerning bronchial asthma, hay fever, and eczema in the target child and family history of respiratory allergy. A detailed family history and personal histories of asthma were available for 1035 Saudi children aged 7–12 years old. The rate of asthma and hay fever were significantly higher among siblings and offspring (cases) compared to their parents (p < 0.001). The results showed a high positive correlation between the relatives of affected children with respect to asthma and hay fever. These findings support the hypothesis that asthma and hay fever may be inherited in the Saudi population, but the mode of inheritance has yet to be determined.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Adkinson J. (1920): The behaviour of bronchial asthma as an inherited character - Genetics5: 363–367.

    Google Scholar 

  2. Al-Frayh A.R.,AI-Nahdi M.,Bener A. andAl-Jawadi T.Q. (1989): Epidemiology of asthma and allergic rhinitis in two coastal areas of Saudi Arabia school children - International Journal of Allergie and Immunologie XXI, No. 10 December: 389–393.

    Google Scholar 

  3. Carter C.O. (1969): Genetics of common disorders -Brit. Med. Bull.25: 52.

    Google Scholar 

  4. Drinkwater H. (1909): Heredity of Bronchial Asthma -Br. Med. J.1: 88.

    Google Scholar 

  5. Edfors-Lubs M.L. (1971): Allergy in 7000 twin pairs -Acta Allergologica26: 249–285.

    Google Scholar 

  6. Hopp R.J.,Bewtra A.K.,Biven R.,Nair N.M. andTownley G. (1986): Bronchial activity patterns in nonasthmatic parents of asthmatic - Ann. Allergy61: 184–186.

    Google Scholar 

  7. Hopp R.J.,Bewtra A.L. andNair N.M. (1986): Methacholine inhalation challenge studies in selected pediatric population - Am. Rev. Respir. Dis.134: 994.

    Google Scholar 

  8. Hopp R.J.,Bewtra A.X. andWatt G.D. (1984): Genetic analysis of allergic disease in twins - J. Allergy Clin. Immunol.73: 265–270.

    Google Scholar 

  9. Horwood L.G.,Ferguson D.M. andShannon F.T. (1985): Social and familial factors in the development of early childhood asthma - Pediatrics75: 859.

    Google Scholar 

  10. Jaggi O.P. (1974): Asthma and other allergies - New Delhi: Orient Longman.

    Google Scholar 

  11. Konig P. andGodfrey S. (1973): Prevalence of exercise-induced bronchial lability in families of children with asthma - Archives of disease childhood48: 513–518.

    Google Scholar 

  12. Leigh D. andMarley E. (1967): Bronchial Asthma, A genetic, Population and Psychiatric study - Pergamon Press - Oxford.

    Google Scholar 

  13. Longo G.,Strinat R. andPoli F. (1987): Genetic factors in non-specific bronchial hyperactivity - Am. J. Dis. Child.141: 331–334.

    Google Scholar 

  14. Rodriguez Y.A.,Tejeiro E.A.,Gomez E.A.,Bacallao G.J. andRodriguez G.R. (1975): Investigation of the prevalence and inheritance of bronchial asthma in San Antonia de la Banos, Cuba - Bull. Pan. Am. Health Org.9: 221.

    Google Scholar 

  15. SAS Institute (1985): SAS users Guide: Statistics SAS Institute, Cary, NC.

    Google Scholar 

  16. Schenker M.B.,Samet J.M. andSpeizer F.E. (1983): Risk factors for childhood respiratory disease: the effects of host factors and home environment exposures - Am. Rev. Respir. Dis.128: 1038–1043.

    Google Scholar 

  17. Schnyder Y. W. (1960): Neurodermitis asthma-rhinitis -Acta Genet. Statist. Med.10: Suppl.: 1–90.

    Google Scholar 

  18. Schwartz M. (1952): Heredity in bronchial asthma -Acta Allergologica5: Suppl.: 2–19.

    Google Scholar 

  19. Sibbald B.,Horn M.E.C.,Brain E.A. andGregg I. (1980): Genetic Factors in Childhood Asthma -Thorax35: 671–674.

    Google Scholar 

  20. Sibbald B.,HornM.E.C. andGreggI. (1980b): A family study of genetics of asthma and wheezy bronchitis - Arch. Dis. Child.55: 354–357.

    Google Scholar 

  21. Spain W.C. andCooke R.A. (1924): Studies in specific hypersensitiveness: The familial occurrence of hay fever and bronchial asthma - J. Immunol.9: 521.

    Google Scholar 

  22. Townley G.,Guirgis H. andBewtra A. (1976): IgE levels and metacholine inhalation responses in monozygous and dizygous twins - J. Allergy Clin. Immunol.57: 227–234.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Additional information

Corresponding author.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bener, A., Al-Jawadi, T.Q., Simsek, M. et al. Heredity of asthma in Saudi population. Eur J Epidemiol 8, 733–736 (1992). https://doi.org/10.1007/BF00145392

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00145392

Key words

Navigation