Abstract
Forty-nine isolates of Campylobacter pylori were tested for their susceptibility to twenty antibiotics and four anti-ulcer agents by an agar dilution technique. Penicillin and amoxycillin were the most active drugs (MIC90, 0.06 μ/ml); erythromycin, cefazolin, minocycline, ciprofloxacin, ofloxacin and gentamicin were sligthtly less active (MIC90, ≤ 1 μg/ml). Moderate activity was found for doxycyclin, rifampin, nitrofurantoin, norfloxacin, pefloxacin, enoxacin, paromomycin, metronidazole and tinidazole. All strains were resistant to trimethoprim (MIC > 512 μg/ml). Nalidixic acid (MIC90, > 256 μg/ml) and colistin (MIC90, > 64 μgg/m1) had little to no activity. Of four anti-ulcer drugs, only bismuth subcitrate showed activity (MIC90, 64 μg./ml).
Strains resistant to all 4-quinolones were found in patients who had previously received ofloxacin as part of a clinical trial aimed at eradication of C. pylori. These isolates remained susceptible to amoxycillin, tetracyclines and to other classes of antibiotics.
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Glupczynski, Y., Delmee, M., Bruck, C. et al. Susceptibility of clinical isolates of campylobacter pylori to 24 antimicrobial and anti-ulcer agents. Eur J Epidemiol 4, 154–157 (1988). https://doi.org/10.1007/BF00144743
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DOI: https://doi.org/10.1007/BF00144743