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Comparisons between the inorganic content of healthy and hypertensive rat tissues by inductively coupled plasma-mass spectrometry

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Abstract

The inorganic contents of bone, brain, erythrocyte, heart, kidney cortex, kidney medulla, liver, lung, muscle and plasma from spontaneously hypertensive rats were compared with those of the same tissues from healthy Sprague-Dawley rats. A general inductively coupled plasma-mass spectrometry method developed for multi-element determinations of most of the elements present in biological tissues was used. Variations were found not only for major elements, as expected, but also for many trace elements in several tissues.

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References

  • Allen BC. 1981 In: Williams DF ed. Systemic Aspects of Biocompatibility, Vol. 1. Boca Raton: CRC Press.

    Google Scholar 

  • Blaustein MP, Hamlyn JM. 1984 Sodium transport inhibition, cell calcium, and hypertension. The natriuretic hormone/Na+-Ca2+ exchange/hypertension hypothesis. Am J Med 64, 45–59.

    Article  Google Scholar 

  • Chase HS. 1984 Does calcium couple the apical and basolateral membrane permeabilities in epithelia? Am J Physiol 247, F869-F876.

    Google Scholar 

  • Cotran RS, Kumar V, Robbins SL. 1989 The kidney. In: Saunders WB ed. Robbins Pathologic Basis of Disease, 4th edn. Philadelphia: Harcourt Brace Jovanovich.

    Google Scholar 

  • Date AR, Stuart HE. 1988 Application of ICP-MS to the simultaneous determination fo chlorine, bromine, and iodine in the NBS standard reference material 1648 Urban Paniculate. J Anal Atom Spectrosc 3, 659–665.

    Google Scholar 

  • Gayton AC et al. 1986 Current concepts and perspectives of renal volume regulation in relationship of hypertension. J Hypertens 4, S47-S51.

    Google Scholar 

  • Gélinas Y, Youla M, Béliveau R, Schmit JP. 1992 Multi-element analysis of biological tissues by inductively coupled plasma mass spectrometry: healthy Sprague Dawley rats. Anal Chim Acta 269, 115–122.

    Google Scholar 

  • Gmaj P, Murer H, Bianchi G. 1988 Abnormal regulation of calcium transport in renal basolateral plasma membranes of milan hypertensive rats. In: Progress in Clinical and Biological Research, Vol. 232. New York: AR Liss.

    Google Scholar 

  • Imaoka T. 1987 Function of platelet 47K protein phosphorylation. Fed Proc 46, 2064.

    Google Scholar 

  • Jiang SJ, Houk RS. 1988 ICP-MS detection for phosphorus and sulfur compounds separated by liquid chromatography. Spectrochim Acta 43B, 405–411.

    Google Scholar 

  • Kaplan NM. 1988 Systemic hypertension: mechanisms and diagnosis. In: Saunders WB ed. Heart Disease, 3rd edn. Philadelphia: Harcourt Brace Jovanovich.

    Google Scholar 

  • Karppanen H. 1985 Electrolytes and hypertension. Ann Clin Res 17, 123–125.

    Google Scholar 

  • Langard S, Hensten-Petterson A. 1981 In: Williams DF ed. Systemic Aspect of Biocompatibility, Vol. 1. Boca Raton: CRC Press.

    Google Scholar 

  • Oster O, Prellwitz W, Luley C. 1986 The relationship between selenium and coronary heart disease. In: Bratter P, Schramel P, eds. Trace Element Analytical Chemistry in Medicine and Biology, Vol. 4. Berlin: W. de Gruyter Co.

    Google Scholar 

  • Punsar S et al. 1975 Coronary heart disease and drinking water. A search in two Finnish male cohorts for epidemiologic evidence of a water factor. J Chron Dis 28, 259–287.

    Google Scholar 

  • Rae T. 1981 In: Williams DF ed. Systemic Aspects of Biocompatibility, Vol. 1. Boca Raton: CRC Press.

    Google Scholar 

  • Schmit JP, Youla M, Ferraris J. Gélinas Y. 1991 Multielement analysis of biological tissues by inductively coupled plasma mass spectrometry. Anal Chim Acta 249, 495–501.

    Google Scholar 

  • Skeggs LT. 1986 Current concepts and historical perspectives of renal presser mechanisms. J Hypertens 4, S3-S10.

    Google Scholar 

  • Stoecker BJ, Li YC. 1988 Chromium and vanadate supplementation of obese and lean mice. In: Hurley LS ed. Trace Elements in Man and Animals —6. New York: Plenum Press.

    Google Scholar 

  • Teraoka H. 1981 Distribution of 24 elements in the internal organs of normal males and the metallic workers in Japan. Arch Environ Health 36, 155–165.

    Google Scholar 

  • Watson RE ed. 1987 Nutrition and Heart Disease, Vol. II, Boca Raton: CRC Press.

    Google Scholar 

  • Windhager EE et al. 1988 Measurements of a i Ca, a i Na and membrane potential and patch clamp studies of the effect of changes in a i Ca on Na channel activity in renal tubules. In: Progress in Clinical and Biological Research, Vol. 252. New York: AR Liss.

    Google Scholar 

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Gélinas, Y., Schmit, JP. Comparisons between the inorganic content of healthy and hypertensive rat tissues by inductively coupled plasma-mass spectrometry. Biometals 7, 155–162 (1994). https://doi.org/10.1007/BF00140486

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