Summary
Low concentrations of acetic acid decreased the growth rate of and astaxanthin production by Phaffia rhodozyma on glucose, with growth completely inhibited by 2 g acetic acid/l. Using H2SO4 for pH control after sugar depletion caused a decline in the biomass concentration, whereas using acetic acid as titrant resulted in an increase in the biomass with a high astaxanthin content of 1430 μg/g cells. An extended culture with a continuous glucose feed failed to maintain a high astaxanthin content.
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Meyer, P.S., du Preez, J.C. Effect of acetic acid on astaxanthin production by Phaffia rhodozyma . Biotechnol Lett 15, 919–924 (1993). https://doi.org/10.1007/BF00131757
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DOI: https://doi.org/10.1007/BF00131757