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Modified carbon flux during oxygen limited growth of Corynebacterium glutamicum and the consequences for amino acid overproduction

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Summary

The amino acid producing bacterium Corynebacterium glutamicum accumulated lactate, succinate and acetate under oxygen-limited growth conditions. Significant restructuring of carbon flux through the central metabolic pathways occurred with a notable decrease in pentose pathway flux and the operation of the TCA cycle in a reductive mode. Simultaneous consumption of residual sugar and organic acids took place when oxygen sufficient conditions were restored though amino acids yields were significantly perturbed.

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Authors and Affiliations

  1. Dept Génie Biochimique et Alimentaire, Lab Ass INRA, URA CNRS N∘ 544, Institut National des Sciences Appliquées, Complexe Scientifique de Rangueil, 31077, Toulouse, France

    H Dominguez, C Nezondet, N D Lindley & M Cocaign

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  1. H Dominguez
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  2. C Nezondet
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  3. N D Lindley
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  4. M Cocaign
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Dominguez, H., Nezondet, C., Lindley, N.D. et al. Modified carbon flux during oxygen limited growth of Corynebacterium glutamicum and the consequences for amino acid overproduction. Biotechnol Lett 15, 449–454 (1993). https://doi.org/10.1007/BF00129316

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  • DOI: https://doi.org/10.1007/BF00129316

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