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Viscoelastic properties modulation of a novel autocrosslinked hyaluronic acid polymer

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Autocrosslinked polysaccharide (ACP) polymers are inter- and intra-molecular esters of hyaluronan (HA) in which part of the carboxyl group is esterified with hydroxyl groups of the same and/or different molecules of the polysaccharides. Suspensions of ACPs in bidistilied water, with relative levels of crosslinking varying from 5% to 20% and different weight concentrations, were obtained to analyse their viscoelastic properties. The steady shear tests showed the pseudoplastic behaviour of ACP, viscosity having a higher value at higher concentrations and degrees of crosslinking. The viscoelastic properties showed an essentially elastic behaviour in the examined frequency range, and they can be modulated by varying both the degree of crosslinking and the weight concentration.

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Authors and Affiliations

  1. Department of Materials and Production Engineering, University of Naples “Federico II”, P.le Tecchio 80, Naples, Italy

    M. Mensitieri, L. Ambrosio & L. Nicolais

  2. Institute of Composite Materials Technology-CNR, P.le Tecchio 80, Naples, Italy

    M. Mensitieri, L. Ambrosio & L. Nicolais

  3. FAB Fidia Advanced Biopolymers Srl, Via Ponte della Fabbrica 3/A, 35031, Abano Terme, Padova, Italy

    D. Bellini

Authors
  1. M. Mensitieri
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  2. L. Ambrosio
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  3. L. Nicolais
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  4. D. Bellini
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  5. M. O'Regan
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Additional information

This paper was accepted for publication after the 1995 Conference of the European Society of Biomaterials, Oporto, Portugal, 10–13 September.

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Mensitieri, M., Ambrosio, L., Nicolais, L. et al. Viscoelastic properties modulation of a novel autocrosslinked hyaluronic acid polymer. J Mater Sci: Mater Med 7, 695–698 (1996). https://doi.org/10.1007/BF00123409

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  • DOI: https://doi.org/10.1007/BF00123409

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