A quickly setting calcium phosphate-based hydraulic cement mixed with particles of tricalcium phosphate (TCP) ceramic was implanted in 56 metaphysial defects made in the long bones of ten adult mongrel dogs. Microradiography, histology and scanning electron microscopy (SEM) demonstrated the slow resorption of the cement and the bony incorporation of the calcium phosphate ceramic particles which were consistently embedded in bone. The original structural pattern of the bone tended to be restored 7 months after implantation. The cement did not hinder the incorporation of the calcium phosphate ceramic particles, neither did it elicit any inflammatory or foreign-body response. The cement was easily shaped and allowed a perfect filling of any defect, resulting in close contact of the whole implant surface with the host bone at the time of surgery, associated with appreciable mechanical strength. Most of the practical problems associated with the use of calcium phosphate ceramics in the repair of bone defects could be overcome with the cement.
Similar content being viewed by others
References
S. N.BHASKAR, J. M.BRADY, L.GETTER, M. F.GROWER and T.DRISKELL, Oral Surg. 32 (1971) 336.
I. W.DENISSEN, K.deGROOT, P. C.MAKKES, A.Van DenHOOFF and P. J.KLOPPER, J. Biomed. Mater. Res. 14 (1980) 713.
B. V.REJDA, J. G. J.PEELEN and K.deGROOT, J. Bioengng 1 (1976) 93.
M.JARCHO, J. F.KAY, K. I.GUMAER, R. H.DOREMUS and H. P.DROBECK, J. Bioengng 1 (1976) 79.
M.JARCHO, Clin. Orthop. 157 (1981) 259.
J.LEMAÎTRE, A. A.MIRTCHI and A.MORTIER, Silicon Int. Ceram. Sci. Technol. 52 (1987) 141.
A. A.MIRTCHI, J.LEMAÎTRE and N.TERAO, Biomaterials 10 (1989) 475.
A. A.MIRTCHI, J.LEMAÎTRE and E.MUNTING, Biomaterials 10 (1989) 634.
A. A.MIRTCHI, J.LEMAÎTRE and E.MUNTING, Biomaterials 11 (1990) 83.
J.RAVEH, H.STICH and F.SUTTER, Struct. Struers Metall. News 6 (1983) 13.
R. E.HOLMES, Plast. Reconstruct. Surg. 63 (1979) 626.
R.LING, Clin. Orthop. 210 (1986) 80.
L.LINDER, Acta Orthop. Scand. 60 (1989) 129.
T.ALBREKTSSON and A.ALBREKTSSON, Acta Orthop. Scand. 58 (1978) 567.
L.CARLSSON, T.RÖSTLUND, A.ALBREKTSSON and T.ALBREKTSSON, Acta Orthop. Scand. 59 (1988) 272.
M.URIST, in “Fundamental and Clinical Bone Physiology” (Lippincott, Philadelphia, 1980) p. 334.
L. L.HENCH, R. J.SPLINTER, W. C.ALLEN and T. K.GREENLEE, J. Biomed. Mater. Res. Symp. 2 (1971) 117.
L. L.HENCH and J.WILSON, Science 226 (1984) 630.
R. E.HOLMES, R. W.BUCHOLZ and V.MOONEY, Bone Joint Surg. 68A (1986) 904.
H.A.HOOGENDOORN, W.RENOOIJ, L. M. A.AKKERMANS, W.VISSER and P.WITTEBOL, Clin. Orthop. 187 (1984) 281.
E.MUNTING, M.VERHELPEN, F.LI and A.VINCENT, in “Handbook of Bioactive Ceramics”, Vol II: “Calcium Phosphate and Hydroxylapatite Ceramics”, edited by T.YAMAMURO, L.HENCH and J.WILSON (CRC Press, Boca Raton, Florida, 1990) p. 143.
K.SOBALLE, E.STENDER HANSEN, H.BROCKSTEDT-RASMUSSEN, C.MOGER PEDERSEN and C.BÜNGER, Acta Orthop. Scand. 61 (1990) 299.
G.GUILLEMIN, A.MEUNIER, P.DALLANT, P.CHRISTEL, J.-C.POULIQUEN and L.SEDEL, J. Biomed. Mater. Res. 23 (1989) 765.
M. WALKER and J. KATZ, in Proceedings of the 30th Annual ORS, Atlanta, February 1984, p. 122.
J. O.GALANTE and D. P.RIVERO in “Advanced Concepts in Total Hip Replacement”, edited by W. H.HARRIS (Slack, Thorofard, New Jersey, 1985).
J.HUPP and S.MCKENNA, J. Oral Maxillofac. Surg. 46 (1988) 538.
J. F.OSBORN, Dtsch Zahnärzt. Z. 38 (1983) 956.
B. D.KATTHAGEN and H.MITTELMEIER, Arch. Orthop. Trauma Surg. 103 (1984) 291.
S.HIGASHI, T.YAMAMURO, T.NAKAMURA, Y.IKADA, S. H.HYON and K.JAMSHIDI, Biomaterials 7 (1986) 183.
J. SUGANUMA, H. ALEXANDER, J. TRAUB and J. L. RICCI, in Proceedings of the Combined Meeting of the Orthopaedic Research Societies of USA, Japan and Canada, Banff, October 1991, p. 89.
H. G.WILLERT, J.LUDWIG and M.SEMLITSCH, J. Bone Joint Surg. 56A (1974) 1368.
N. EFTEKAR, S. DATY, A. JOHNSTON and M. PARISIEN, in “The Hip”. Proceedings of the 13th Open Scientific Meeting of the Hip Society, edited by R. H. Fitzgerald (Mosby, 1985) p. 169.
L.LINDER and H.HANSSON, J. Bone Joint Surg. 65B (1983) 646.
M. A. R.FREEMAN, G. W.BRADLEY and P. A.REVELL, J. Bone Joint Surg. 64B (1982) 489.
H.DREESMAN, Beitr. Klin. Chir. 9 (1982) 804.
L. F.PELTIER, Clin. Orthop. 21 (1961) 1.
J. S. HANKER, B. C. TERRY, W. W. AMBROSE and C. R. LUPTON, US Patent 4619655 (28 October 1986).
W. BROWN, L. C. CHOW, US Patent 4 (20 October 1985) 430 518.
H.MONMA, T.TAKAHASHI, H.USHIO, S.SOEDA and T.KIYOSAWA, Gypsum Lime 212 (1988) 25.
M.WINTER, P.GRISS, K.deGROOT, H.TAGAI, G.HEIMKE, H. J. A. V.DIJK and K.SAWAI, Biomaterials 2 (1981) 159.
C. P. A. T.KLEIN, A. A.DRIESSEN and K.deGROOT, J. Biomed. Mater. Res. 17 (1983) 769.
G.DALCUSI, R.LEGROS, M.HEUGHEBAERT and I.BARBIEUX, Calcif. Tissue Int. 46 (1990) 20.
S.KOTANI, Y.FUJITA, T.KITSUGI, T.NAKAMURA, T.YAMAMURO, C.OHTSUKI and T.KOKUBO, J. Biomed. Mater. Res. 25 (1991) 1304.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Munting, E., Mirtchi, A.A. & Lemaitre, J. Bone repair of defects filled with a phosphocalcic hydraulic cement: an in vivo study. J Mater Sci: Mater Med 4, 337–344 (1993). https://doi.org/10.1007/BF00122290
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00122290