Some important eye pathologies, such as diabetic proliferative retinopathy and retinal detachment, are strictly connected to different gel vitreus alterations. Therefore there is a strong need in ophthalmology for vitreal substitutes. Until now many synthetic and natural polymers have been tested as vitreal substitutes, but no one has proved to be an ideal vitreal substitute. An ideal vitreal substitute, apart from other characteristics, such as transparency, permanency, biocompatibility, etc. must have a rheological behaviour compatible with the surrounding tissues. The viscoelastic behaviour of different animals' gel vitreus, evaluated by means of steady shear viscosity and small-amplitude oscillatory measurements, is typical of solid-like rubbery gels with dynamic elastic modulus G′ higher than the dynamic viscous modulus G″ in the typical frequency range investigated (0.05–10 Hz). On the other hand the rheological behaviour of current or candidate vitreal substitutes (silicone oil, HPMC, high molecular weight hyaluronic acid and chemically-crosslinked hyaluronic acid), analysed with the same technique, is generally different from that of natural vitreus.
Similar content being viewed by others
References
J. E. SCOTT, Eye 6 (1992) 553.
E. A. BALAZS and J. L. DENLINGER, in “The eye, Vol. Ia, Vegetative physiology and biochemistry”, edited by H. DAVSON, 3rd edition (Academic Press, New York, 1984) p. 533.
F. A. BETTELHEIM and T. J. Y. WANG, Exp. Eye Res. 23 (1976) 435.
C. L. SCHEPENS, Bull. Soc. Belge Opthal. 223-I (1987) 85.
M. DOI, in “Materials science and technology, Vol. 12, Structure and properties of polymers”, edited by E. L. THOMAS (VCH, Weinheim, 1993) p. 389.
J. D. FERRY, in “Viscoelastic properties of polymers” (J. Wiley, New York, 1970).
J. E. SCOTT, Biochem. J. 252 (1988) 313.
R. MAYNE, R. G. BREWTON, D. W. WRIGHT and Z. X. REN, in “Biochemistry of the eye”, Biochemical Society Transactions 19 (1991).
J. L. DENLINGER and E. A. BALAZS, in “Vision and visual health care, Vol. 2-Viscoelastic materials”, edited by E. S. ROSEN (Pergamon Press, Oxford, 1989) p. 185.
U. B. G. LAURENT and K. A. GRANATH, Exp. Eye Res. 36 (1983) 481.
S. B. ROSS-MURPHY, in “Polymer gels. Fundamentals and biomedical applications”, edited by D. De ROSSI, K. KAJIWARA, Y. OSADA and A. YAMAUCHI (Plenum Press, New York, 1991) p. 21.
V. P. GABEL, A. KAMPIK and J. BURKHARDT, Graefe's Arch. Clin. Exp. Ophthalmol. 225 (1987) 160.
E. S. ROSEN and R. P. F. GREGORY, in “Vision and visual health care, Vol. 2-Viscoelastic materials”, edited by E. S. ROSEN (Pergamon Press, Oxford, 1989) p. 31.
R. KOSTER and J. S. STILMA, Documenta Ophthalmologica 61 (1986) 247.
H. BOTHNER and O. WIK, in “Vision and visual health care, Vol. 2-Viscoelastic materials”, edited by E. S. ROSEN (Pergamon Press, Oxford, 1989) p. 53.
E. A. BALAZS, in “Vision and visual health care, Vol. 2-Viscoelastic materials”, edited by E. S. ROSEN (Pergamon Press, Oxford, 1989) p. 167.
J. L. DENLINGER and E. A. BALAZS, Exp. Eye Res. 30 (1980) 101.
United States Patent N. 4713488 (1987).
E. A. BALAZS, P. A. BLAND, J. L. DENLINGER, A. I. GOLDMAN, N. E. LARSEN, E. A. LESHCHINER, A. LESHCHINER and B. MORALES, Blood Coagulation and Fibrinolysis 2 (1991) 173.
A. VADAZS, E. A. BALAZS, A. GOLDMAN et al., Proc. Int. Soc. for Eye Res. 5 (1988) 67.
Author information
Authors and Affiliations
Additional information
Department of Materials and Production Engineering, University of Naples “Federico II”
Rights and permissions
About this article
Cite this article
Mensitieri, M., Ambrosio, L., Nicolais, L. et al. The rheological behaviour of animal vitreus and its comparison with vitreal substitutes. J Mater Sci: Mater Med 5, 743–747 (1994). https://doi.org/10.1007/BF00120368
Issue Date:
DOI: https://doi.org/10.1007/BF00120368