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In vivo behaviour of three calcium phosphate cements and a magnesium phosphate cement

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Three types of calcium phosphate cements and one magnesium phosphate cement were implanted subcutaneously in rats under exclusion of direct cellular contact. Retrieval times were either 1, 2, 4 or 8 weeks. Before and after retrieval the compressive strength, the diametral tensile strength, the quantitative chemical composition, the qualitative phase composition, the FTIR spectrum and the microstructure were determined. The three calcium phosphate cements maintained their strength during implantation. The phase DCPD was completely transformed into a Na- and CO3-containing apatite, the phases DCP and CDHA only partially. It could not be ruled out that OCP is also transformed into a bone-mineral-like apatite to a certain extent. That this latter process occurs much faster during the turn-over of living bone, is probably due to the very small crystal size of the OCP particles in bone.

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Author notes

  1. O. Bérmúdez

    Present address: Dept de Fisica, Universidad del Cauca, Popayán, Colombia

Authors and Affiliations

  1. Dept de Ciencia dels Materials i Enginyeria Metal.lúrgica, Universitat Politècnica de Catalunya, Avda. Diagonal 647, 08028, Barcelona, Spain

    F. C. M. Driessens, M. G. Boltong, E. Fernández, M. P. Ginebra & J. A. Planell

  2. Centro de Investigación y Desarrollo Aplicado, Centro Industrial Santiga, C/Argenters 6, 08130-Santa Perpètua de Mogoda, (Barcelona), Spain

    M. I. Zapatero

  3. Laboratory for Analytical Chemistry, University of Ghent, Krijgslaan 281-S12, B-9000, Gent, Belgium

    R. M. H. Verbeeck

  4. Interdisciplinary Research Centre in Biomedical Materials, Queen Mary and Westfield College, Mile End Road, E1 4NS, London, UK

    W. Bonfield & O. Bérmúdez

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  1. F. C. M. Driessens
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Driessens, F.C.M., Boltong, M.G., Zapatero, M.I. et al. In vivo behaviour of three calcium phosphate cements and a magnesium phosphate cement. J Mater Sci: Mater Med 6, 272–278 (1995). https://doi.org/10.1007/BF00120270

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  • DOI: https://doi.org/10.1007/BF00120270

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