Summary
Two phosphono desmuramyldipeptide analogs, 6 and 11, were synthesized and evaluated for immunomodulatory activity. Phthalimido-and adamantyl-substituted side chains as a replacement for the N-acetylmuraminic acid were coupled with appropriate dipeptides using DPPA as the coupling reagent. Introduction of a phosphonamidate moiety in compound 6 resulted in lower biological activity.
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Urleb, U., Gobec, S. & Prelog, D. Synthesis and activity of phosphono desmuramyldipeptide analogs. Lett Pept Sci 2, 193–197 (1995). https://doi.org/10.1007/BF00119151
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DOI: https://doi.org/10.1007/BF00119151