Skip to main content
Log in

Respiratory function in the elderly and the effects of beta blockade

  • Cerebral Blood Flow, Cardiovascular Reflexes, and Respiratory Function
  • Published:
Cardiovascular Drugs and Therapy Aims and scope Submit manuscript

Summary

Bronchoconstriction, the main respiratory side effect from beta-blocking drugs, can be severe and precipitous in patients with asthma, but at most is very minor in patients with chronic bronchitis. Elderly patients with asthma and chronic bronchitis appear to run a similar risk from betablocking drugs as younger patients with these conditions, though there are no direct comparisons. Several studies have looked at the response of elderly patients to beta-blocking drugs, and the profile and incidence of respiratory side effects has been similar to those seen in studies of younger subjects. There is a greater danger in the elderly that a past history of asthma may be overlooked or that bronchoconstriction from a beta-blocking drug is attributed to other causes.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Gibson GJ, Pride NB, O'Cain C, Quagliato R. Sex and age differences in pulmonary mechanics in normal non-smoking subjects. J Appl Physiol 1976;41:20–25.

    Google Scholar 

  2. Sorbini CA, Grassi V, Solinas E, Muiesan G. Arterial oxygen tension in relation to age in healthy subjects. Respiration 1968;25:3–13.

    Google Scholar 

  3. Fowler RW, Pluck RA, Hetzel MR. Maximal expiratory flow-volume curves in Londoners aged 60 years and over. Thorax 1987;42:173–182.

    Google Scholar 

  4. Fletcher C, Peto R. The natural history of chronic airflow obstruction. Br Med J 1977;1:1645–1648.

    Google Scholar 

  5. Kronenberg RS, Drage CW. Attenuation of the ventilatory and heart rate responses to hypoxia and hypercapnia with aging in normal men. J Clin Invest 1973;52:1812–1819.

    Google Scholar 

  6. Burr M, Phillips KM, Hurst DN. Lung function in the elderly. Thorax 1985;40:54–59.

    Google Scholar 

  7. Burr ML, Charles TJ, Roy K, Seaton A. Asthma in the elderly: An epidemiological survey. Br Med J 1979;1:1041–1044.

    Google Scholar 

  8. Cullinan P. Respiratory Disease in England and Wales. Thorax 1988;43:949–54.

    Google Scholar 

  9. Mustchin CP, Gribbin HR, Tattersfield AE, George CF. Reduced respiratory response to carbon dioxide after propranolol: A central action? Br Med J 1976;2:1229–1231.

    Google Scholar 

  10. Patrick JM, Tutty J, Pearson JB. Propranolol and the ventilatory response to hypoxia and hypercapnia in normal man. Clin Sci Mol Med 1978;55:491–497.

    Google Scholar 

  11. Tattersfield AE. Beta adrenoceptor antagonists and respiratory disease. J Cardiovasc Pharmacol 1986;8(Suppl 4):535–539.

    Google Scholar 

  12. Benson MK, Berrill WT, Cruiekshank JM, Sterling GS. A comparison of four beta-adrenoceptor antagonists in patients with asthma. Br J Clin Pharmacol 1987;5:415–419.

    Google Scholar 

  13. Larsson K. Influence of labetolol, propranolol and practolol in patients with asthma. Eur J Respir Dis 1982;63;221–230.

    Google Scholar 

  14. Thomson NC, Daniel EE, Hargreave FE. Role of smooth muscle alpha1-receptors in nonspecific bronchial responsiveness in asthma. Am Rev Respir Dis 1982;126:521–525.

    Google Scholar 

  15. Dunn TL, Gerber MJ, Shen AS, et al. The effect of topical ophthalmic instillation of timolol and betaxolol on lung funetion in asthmatic subjects. Am Rev Respir Dis 1986;133: 264–268.

    Google Scholar 

  16. Williams IP, Millard FJC. Severe asthma after inadvertent ingestion of oxprenolol. Thorax 1980;35:160.

    Google Scholar 

  17. Fraunfelder FT, Barker AF. Respiratory effects of timolol. N Engl J Med 1984;311:1441.

    Google Scholar 

  18. Perks WH, Chatterjee SS, Croxson RS, Cruickshank JM. Comparison of atenolol and oxprenolol in patients with angina or hypertension and co-existent chronic airways obstruction. Br J Clin Pharmacol 1978;5:101–106.

    Google Scholar 

  19. Nordstrom LA, MacDonald F, Gobel FL. Effect of propranolol on respiratory function and exercise tolerance in patients with chronic obstructive lung disease. Chest 1975; 67:287–292.

    Google Scholar 

  20. van Herwaarden CLA. Beta-adrenoceptor blockade and pulmonary function in patients suffering from chronic obstructive lung disease. J Cardiovasc Pharmacol 1983;5:S46-S50.

    Google Scholar 

  21. Sinclair DJM. Comparison of effects of propranolol and metoprolol on airways obstruction in chronic bronchitis. Br Med J 1979;1:168.

    Google Scholar 

  22. Lammers JWJ, Folgering HTM, van Herwaarden CLA. Ventilatory effects of long term treatment with pindolol and metoprolol in hypertensive patients with chronic obstructive lung disease. Br J Clin Pharmacol 1985;20:205–210.

    Google Scholar 

  23. Larsson K. Influence of labetolol, propranolol and practolol in patients with asthma. Eur J Respir Dis 1982;63:221–230.

    Google Scholar 

  24. Formgren H. The effect of metoprolol and practolol on lung function and blood pressure in hypertensive asthmatics. Br J Clin Pharmacol 1976;3:1007–1014.

    Google Scholar 

  25. Northcote RJ, Ballantyne D. Influence of intrinsic sympathomimetic activity on respiratory function during chronic beta blockade: Comparison of propranolol and pindolol. Br Med J 1986;293:97–99.

    Google Scholar 

  26. Hawkins CM, Richardson DW, Vokonas PS. Effect of propranolol in reducing mortality in older myocardial infarction patients. The beta-blocker heart attack trial experience. Circulation 1983;67:94–97.

    Google Scholar 

  27. Wikstrand J, Westergren G. Berglund G, et al. Antihypertensive treatment with metoprolol or hydrochlorothiazide in patients aged 60–75 years; Report from a double-blind international multicentre study. JAMA 1986;255:1304–1310.

    Google Scholar 

  28. Currie WJC, Vandenburg MJ, Cooper WD. Do elderly patients respond differently to treatment with Moducren? Br J Clin Pract 1984;38:102–106.

    Google Scholar 

  29. O'Malley K, Kelly JG. Aging and responsiveness to drugs. In: Turner P, Shand DG, eds. Recent advances in clinical pharmacology. London: Churchill-Livingstone, 1983:45–56.

    Google Scholar 

  30. Ullah MI, Newman GB, Saunders KB. Influence of age on response to ipratropium and salbutamol in asthma. Thorax 1981;36:523–529.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Tattersfield, A.E. Respiratory function in the elderly and the effects of beta blockade. Cardiovasc Drug Ther 4 (Suppl 6), 1229–1232 (1991). https://doi.org/10.1007/BF00114225

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00114225

Key Words

Navigation