The role of socioeconomic and anthropometric indicators, tobacco, alcohol consumption, dietary habits, and medical history in the etiology of soft-tissue sarcoma (STS) was examined in a hospital-based case-control study, conducted in the Friuli-Venezia Giulia region of northeast Italy, between 1985 and 1990. A total of 88 STS cases (53 males and 35 females; median age: 52 years) and of 610 controls (306 males and 304 females; median age: 54 years) were interviewed. There were significant excess risks associated with a history of herpes zoster infection (odds ratio [OR]=2.4,95 percent confidence interval [CI]=1.1–5.3), chicken pox (OR=2.2, CI=1.2–4.3) and mumps in childhood (OR=2.0, CI=1.1–3.9). History of diabetes was also linked to a nonsignificant increase in STS risk (OR=1.8, CI=0.6–5.4), whereas exposure to radiation for diagnostic or therapeutic purposes was not related to the probability of developing STS. None of the investigated socioeconomic and anthropometric indicators seemed to affect STS risk; neither did tobacco smoking, nor consumption of alcohol, coffee, and tea beverages. Conversely, among the dietary habits investigated, a significant positive association emerged with an increasing frequency of consumption of dairy products (% MathType!MTEF!2!1!+-% feaafeart1ev1aaatCvAUfeBSjuyZL2yd9gzLbvyNv2CaerbuLwBLn% hiov2DGi1BTfMBaeXafv3ySLgzGmvETj2BSbqefm0B1jxALjhiov2D% aebbfv3ySLgzGueE0jxyaibaiiYdd9qrFfea0dXdf9vqai-hEir8Ve% ea0de9qq-hbrpepeea0db9q8as0-LqLs-Jirpepeea0-as0Fb9pgea% 0lrP0xe9Fve9Fve9qapdbaqaaeGacaGaaiaabeqaamaabaabcaGcba% Gaae4XdmaaCaaaleqabaGaaGOmaaaaaaa!3DA2!\[{\rm{\chi }}^2\]for trend=6.8, P<0.01) and oil (% MathType!MTEF!2!1!+-% feaafeart1ev1aaatCvAUfeBSjuyZL2yd9gzLbvyNv2CaerbuLwBLn% hiov2DGi1BTfMBaeXafv3ySLgzGmvETj2BSbqefm0B1jxALjhiov2D% aebbfv3ySLgzGueE0jxyaibaiiYdd9qrFfea0dXdf9vqai-hEir8Ve% ea0de9qq-hbrpepeea0db9q8as0-LqLs-Jirpepeea0-as0Fb9pgea% 0lrP0xe9Fve9Fve9qapdbaqaaeGacaGaaiaabeqaamaabaabcaGcba% Gaae4XdmaaCaaaleqabaGaaGOmaaaaaaa!3DA2!\[{\rm{\chi }}^2\]for trend=4.3, P<0.05), while a negative association was seen for intake of whole grain bread and pasta (OR for highest cf lowest tertile=0.4, CI=0.2–0.9).
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References
Pickle LW, Mason TJ, Howard N, Fraumeni JF. Atlas of US Cancer Mortality among Whites: 1950–80: Washington, DC: US Department of Health and Human Services, Public Health Service, National Institute of Health, 1987; DHHS Pub. No. 87–2900.
Levi F, Maisonneuve P, Filiberti R, La Vecchia C, Boyle P: Cancer incidence and mortality in Europe. Soz Praeventivmed 1989; 34 (Suppl 2).
La Vecchia C, Decarli A. Trends in cancer mortality in Italy, 1955–1978. Tumori 1985; 71: 201–18.
Tucker MA, Fraumeni JF. Soft-tissue. In: Schottenfeld D, Fraumeni JFJr, eds. Cancer Epidemiology and Prevention. Philadelphia, PA: WB Saunders Company, 1982; 827–36.
(Editorial) Phenoxy herbicides, trichlorophenols, and soft-tissue sarcomas. Lancet 1982; i: 1051–2.
Vineis P, Terracini B, Ciccone G, et al. Phenoxy herbicides and soft tissue sarcomas in female rice weeders. A population based case-referent study. Scand J Work Environ Health 1987; 13: 9–17.
Hoar SK, Blair A, Holmes F. Agriculture herbicide use and risk of lymphoma and soft-tissue sarcoma. JAMA 1986; 256: 1141–7.
Strong LC. Theories of pathogenesis: mutation and cancer. In: Mulvihill JJ, Miller RW, Fraumeni JFJr, eds. Genetics of Human Cancer. New York: Raven Press, 1977: 401–15.
Baird PA, Worth AJ. Congenital generalized fibromatosis: an autosomal recessive condition? Clin Genet 1976; 9: 488–94.
Li FP, Fraumeni JF. Rhabdomyosarcoma in children: epidemiologic study and identification of a family cancer syndrome. JNCI 1969; 43: 1365–73.
Kim JH, Chu FC, Woodward HO, et al. Radiation induced soft-tissue and bone sarcoma. Radiol 1978; 129: 501–8.
Czesin K, Wronkowski Z. Second malignancies of the irradiated area in patients treated for uterine cervical cancer. Gynecol Oncol 1978; 6: 309–15.
Hoover R, Fraumeni JFJr. Risk of cancer in renal transplant recipients. Lancet 1973; ii: 55–7.
Kinlen LJ, Sheil AGR, Peto J, et al. Collaborative United Kingdom-Australasian study of cancer in patients treated with immunosuppressive drugs. Br Med J 1979; 2: 1461–6.
Penn I. Cancers complicating organ transplantation. N Engl J Med 1990; 323: 1767–9.
Enzinger FM, Weiss SW. Soft-tissue Tumors. St Louis, MO: CV Mosby, 1983.
Office of Population Censuses and Surveys. Classification of Occupation 1980. London: HMSO, 1980.
Mantel N, Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease. JNCI 1959; 22: 719–48.
Cornfield J. A statistical problem arising from retrospective studies. In: Neyman J, ed. Proceedings of the Third Berkeley Symposium, IV, Berkeley, CA: University of California Press, 1956.
Breslow NE, Day NE. Statistical methods in cancer research: the analysis of case-control studies. Lyon: International Agency for Research on Cancer, 1980; IARC Sci. Pub. No. 32.
Cartwright RA, McKinney PA, O'Brien C, et al. Non-Hodgkin's lymphoma: case-control epidemiological study in Yorkshire. Leukemia Res 1988; 12: 81–8.
Franceschi S, Serraino D, Bidoli E, et al. The epidemiology of non-Hodgkin's lymphoma in the north-east of Italy: a hospital-based case-control study. Leukemia Res 1989; 13: 465–72.
Rous P. A sarcoma of the fowl transmissible by an agent separable from the tumor cells. J Exp Med 1911; 13: 297–411.
Morton DL. Soft-tissue sarcomas. In: Holland JF, Frei E, eds. Cancer Medicine. Philadelphia, PA: Lea and Febiger, 1973; 1845–61.
Hirshaut Y, Pei DT, Marcove RC et al. Seroepidemiology of human sarcoma antigen (SI). N Engl J Med 1974; 291: 1103–7.
Karpas A, McGeoch V, Tuckerman F, et al. Viral-coded information in human rhabdomyosarcoma cells. Lancet 1974; ii: 1330–1.
Harwood AR, Osoba D, Hofstader SL, et al. Kaposi's sarcoma in recipients of renal transplants. Am J Med 1979; 67: 759–65.
Giraldo G, Beth E, Huang ES. Kaposi's sarcoma and its relationship to cytomegalovirus (CMV): III. CMV DNA and CMV early antigens in Kaposi's sarcoma. Int J Cancer 1978; 26: 23–9.
Rapp F, Cory JM. Viral oncogenesis and the immune system. Cancer Detect Prev 1990; 14: 437–44.
Woods JS, Polissar L, Severson RK, et al. Soft-tissue sarcoma and non-Hodgkin's lymphoma in relation to phenoxyherbicide and chlorinated phenol exposure in western Washington. JNCI 1987; 78: 899–910.
Kang H, Ezinger F, Breslin P, et al. Soft-tissue sarcoma and military service in Vietnam: a case-control study. JNCI 1987; 79: 693–9.
Zahm SH, Blair A, Holmes FF, Boysen CD, Robel RJ, Fraumeni JFJr. A case-control study of soft-tissue sarcoma. Am J Epidemiol 1989; 130: 665–74.
Cunningham AS. Lymphomas and animal protein consumption. Lancet 1976; ii: 1184–6.
Franceschi S, Serraino D, Carbone A, Talamini R, La Vecchia C. Dietary factors and non-Hodgkin's lymphoma: a case-control study in the northeastern part of Italy. Nutr Cancer 1989; 12: 333–41.
Reddy BS. Dietary fiber and colon cancer: animal model studies. Prev Med 1987; 16: 559–65.
Kelly JP, Rosenberg L, Kaufman DW, Shapiro S. Reliability of personal interview data in a hospital-based case-control study. Am J Epidemiol 1990; 131: 79–90.
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Support for this project was contributed by the Italian Association for Cancer Research, Milan, and the Italian National Research Council (CNR Applied Project “Oncology”, Contract 87.01544.44).
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Serraino, D., Franceschi, S., Talamini, R. et al. Non-occupational risk factors for adult soft-tissue sarcoma in northern Italy. Cancer Causes Control 2, 157–164 (1991). https://doi.org/10.1007/BF00056208
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DOI: https://doi.org/10.1007/BF00056208