Skip to main content
SpringerLink
Log in

Familial occurrence of hematologic malignancies and other diseases in multiple myeloma: a case-control study

  • Research Papers
  • Published:
Cancer Causes & Control Aims and scope Submit manuscript

In a population-based case-control study in Sweden on multiple myeloma, the occurrence of different diseases in relatives, particularly hematologic malignancies and different types of cancer, was investigated. Through a questionnaire mailed to all living subjects, i.e. cases and controls, and to the next-of-kin for deceased subjects, information was obtained on malignant and certain other diseases among relatives. All malignant diseases reported among first-degree relatives were verified, if possible, through parochial authorities and the Swedish Cancer Register. In total, data from 239 cases with myeloma and 220 controls were analyzed. An increased risk was found for persons with first-degree relatives with hematologic malignancies (relative risk [RR]=2.36, 90 percent confidence interval [CI]=0.90–6.15), and also with multiple myeloma specifically (RR=5.64, CI=1.16–27.51). An increased risk also was seen if the close relatives had experienced another tumor disease (RR=1.21, CI=0.86–1.71). Particularly, occurrence of prostatic cancer (RR=3.11, CI=1.25–7.71) or brain tumor (RR=6.61, CI=1.42–30.67) in relatives increased the risk for multiple myeloma.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Meyerding HW. Multiple myeloma. Radiology 1925; 5: 132–6.

    Google Scholar 

  2. Geschickter CF, Copeland MM. Multiple myeloma. Arch Surg 1928; 16: 807–63.

    Google Scholar 

  3. Mandema E, Wildervanck LS. La maladie de Kahler (myelomes multiples) chez deux soeurs. J. Genet Hum 1954; 3: 170–5.

    Google Scholar 

  4. Shoenfeld Y, Berliner S, Shaklai M, Gallant LA, Pinkhas J. Familial multiple myeloma. A review of thirty-seven families. Postgrad Med J 1982; 58: 12–6.

    Google Scholar 

  5. Isobe T, Shaura K, Itoh T, Fujita T. Myeloma in siblings. Acta Haematol Jpn 1981; 44: 98–101.

    Google Scholar 

  6. Hubert D, Thomas M, Krulik M, et al. Myelome familial: A propos d'un cas. Rev Med Interne 1985; 5: 447–52.

    Google Scholar 

  7. Judson IR, Wiltshaw E, Newland AC. Multiple myeloma in a pair of monozygotic twins: the first reported case. Br J Haematol 1985; 60: 551–4.

    Google Scholar 

  8. Horwitz LJ, Levy RN, Rosner F. Multiple myeloma in three siblings. Arch Intern Med 1985; 145: 1449–50.

    Google Scholar 

  9. McCrea AP, Morris TCM. Concurrent familial myeloma in Northern Ireland. Cancer 1986; 58: 394–6.

    Google Scholar 

  10. Grosbois B, Gueguen M, Fauchet R, et al. Multiple myeloma in two brothers. An immunochemical and immunogenetic familial study. Cancer 1986; 58: 2417–21.

    Google Scholar 

  11. Eriksson M, Bergström I. Familial malignant blood disease in the county of Jämtland, Sweden. Eur J Haematol 1987; 38: 241–5.

    Google Scholar 

  12. Wirtschafter SK, Rapaport SI. The familial occurrence of chronic lymphocytic leukemia and multiple myeloma. California Med 1960; 92: 165–6.

    Google Scholar 

  13. Kyle RA, Henderson ES, Randolph VL, Budge WR. Multiple myeloma, acute leukemia and Hodgkin's disease: Occurrence in three of four family members. Cancer 1976; 37: 1496–9.

    Google Scholar 

  14. Bourguet CC, Grufferman S, Delzell E, DeLong ER, Cohen HJ. Multiple myeloma and family history of cancer. A case-control study. Cancer 1985; 56: 2133–9.

    Google Scholar 

  15. Grufferman S, Cohen HJ, Delzell ES, Morrison MC, Schold SC, Moore JO. Familial aggregation of multiple myeloma and central nervous system diseases. J Am Geriatr Soc 1989; 37: 303–9.

    Google Scholar 

  16. Linet MS, McLaughlin JK, Harlow SD, Fraumeni JFJr. Family history of autoimmune disorders and cancer in multiple myeloma. Int J Epidemiol 1988; 17: 512–3.

    Google Scholar 

  17. Committee of the chronic leukemia-myeloma task force, NCI. Proposed guidelines for protocol studies. II. Plasma cell myeloma. Cancer Chemother Rep 1968; 1: 17–39.

    Google Scholar 

  18. Miettinen OS. Estimation of relative risk from individually matched series. Biometrics 1970; 26: 75–86.

    Google Scholar 

  19. Miettinen OS. Estimability and estimation in case-referent studies. Am J Epidemiol 1976; 103: 226–35.

    Google Scholar 

Download references

Authors
  1. Mikael Eriksson
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Bengt Hållberg
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Dr Eriksson in with the Department of Oncology, University Hospital, S-901-85 Umeå, Sweden. Dr Hållberg is with the Department of Statistics, Umeå University, Umeå, Sweden. Address correspondence to Dr Eriksson. This research was supported by grants from the Swedish Cancer Fund. (Project 2683-B90-02X.)

Rights and permissions

Reprints and permissions

About this article

Cite this article

Eriksson, M., Hållberg, B. Familial occurrence of hematologic malignancies and other diseases in multiple myeloma: a case-control study. Cancer Causes Control 3, 63–67 (1992). https://doi.org/10.1007/BF00051914

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00051914

Key words

Search

Navigation