A case-control study was conducted in the Minneapolis-St Paul (Minnesota, United States) area to assess the role of dietary factors in the etiology of pancreatic cancer. Cases were White males aged 40 to 84 whose death certificate listed pancreatic cancer (exocrine only). White male controls were ascertained through random-digit dialing. Family members were interviewed about the subject's dietary usage in the two years prior to death (cases, n=212) or prior to interview (controls, n=220). Energy-adjusted,nutrient-intake, risk estimates were calculated. Among all respondents, negative trends were observed for polyunsaturated fat, linoleic acid, vitamin C, and β-carotene. Positive trends were observed for riboflavin and retinol. Point estimates were, in general, comparable between the analyses of all respondents and spouse-only respondents. The nutrients associated with a decreased risk for pancreatic cancer occur primarily in vegetables and fruits, of which the consumption of cruciferous and β-carotene-rich vegetables and citrus fruits provided the greatest reduction in risk.
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References
Durbec JP, Chevillotte G, Bidart JM, Berthezene P, Sarles H. Diet, alcohol, tobacco and risk of cancer of the pancreas: A case-control study. Br J Cancer 1983; 47: 463–70.
Gold EB, Gordis L, Diener MD, et al. Diet and other risk factors for cancer of the panereas. Cancer 1985; 55: 460–7.
Norell SE, Ahlbom A, Erwald R, et al. Diet and pancreatic cancer: A case-control study. Am J Epidemiol 1986; 124: 894–902.
Mack TM, Yu MC, Hanish R, Henderson BE. Pancreas cancer and smoking, beverage consumption, and past medical history. JNCI 1986; 6: 49–60.
Falk RT, Pickle LW, Fontham ET, Correa P, Fraumeni JFJr. Life-style risk factors for pancreatic cancer in Louisiana: A case-control study. Am J Epidemiol 1988; 128: 324–36.
Olsen GW, Mandel JS, Gibson RW, Wattenberg LW, Schuman LM. A case-control study of pancreatic cancer and cigarettes, alcohol, coffee and diet. Am J Public Health 1989; 79: 1016–9.
Farrow DC, Davis S. Diet and the risk of pancreatic cancer in men. Am J Epidemiol 1990; 132: 423–31.
Olsen GW, Mandel JS. Elderly control selection using random digit dialing. Am J Public Health 1988; 78: 1487–8.
Willett W, Stampfer MJ. Total energy intake: implications for epidemiologic analyses. Am J Epidemiol 1986; 124: 17–27.
SAS Institute Inc. SUGI Supplemental Library User's Guide. Cary, NC (US): SAS Institute Inc., 1983.
Willett W. Nutritional Epidemiology. New York: Oxford University Press, 1990: 245–71.
Block G, Dresser CM, Hartman AM, Carroll MD: Nutrient sources in the American diet: quantitative data from the NHANES II survey. II. Macronutrients and fats. Am J Epidemiol 1985; 122: 27–40.
Roebuck BD, Yager JD, Longnecker DS, Wilpone SA. Promotion by unsaturated fat of azaserine-induced pancreatic careinogenesis in the rat. Cancer Res 1981; 41: 3961–6.
Longnecker DS, Wiebkin P, Schaeffer BK, Roebuck BD: Experimental carcinogenesis in the pancreas. Int Rev Exp Pathol 1984; 26: 177–229.
Lew EA, Garfinkel L. Variations in mortality by weight among 750,000 men and women. J Chron Dis 1979; 32: 563–76.
Tanimura H, Takenaka M, Setoyama M. Pathogenesis and treatment of panereatitis due to essential fatty acid deficiency. Gastroenterol Jpn 1977; 12: 484–9.
Krinsky NI, Deneke SM. Interaction of oxygen and oxy-radicals with carotenoids. JNCI 1982; 69: 205–10.
Peto R, Doll R, Buckley JD, Sporn MB. Can dietary beta-carotene materially reduce human cancer rates? Nature 1981; 290: 201–8.
Peto R. The marked differences between carotenoids and retinoids: methodological implications for biochemical epidemiology. Cancer Surv 1983; 2: 237–40.
Longnecker DS, Curphey TJ, Kuhlmann ET. Inhibition of pancreatic carcinogenesis by retinoids in azaserine-treated rats. Cancer Res 1982; 42: 19–24.
Pour PM, Runge RG, Birt D, et al. Current knowledge of pancreatic carcinogenesis in the hamster and its relevance to human disease. Cancer 1981; 47: 1573–87.
Wattenberg LW, Loob WD. Inhibition of polycyclic aromatic hydrocarbon-induced neoplasia by naturally occurring indoles. Cancer Res 1978; 38: 1410–3.
Wattenberg LW. Inhibition of carcinogens-induced neoplasia by sodium cyanate, tert-butyl isocyanate and benzyl isothiocyanate administered subsequent to carcinogen exposure. Cancer Res 1981; 41: 2991–4.
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Authors are at the University of Minnesota. Drs Olsen and Schuman are at the School of Public Health, Division of Epidemiology, Minneapolis, MN, USA. Dr Mandel is with the Division of Environmental and Occupational Health, School of Public Health. Dr Gibson is at the School of Medicine, Department of Behavioral Sciences. Dr Wattenberg is at the School of Medicine, Department of Laboratory Medicine and Pathology. Address correspondence to Dr Olsen, The Dow Chemical Company, Health and Environmental Sciences, Epidemiology, 1803 Building, Midland, MI 48674, USA. This study was supported by grant SIG5 from the American Cancer Society.
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Olsen, G.W., Mandel, J.S., Gibson, R.W. et al. Nutrients and pancreatic cancer: a population-based case-control study. Cancer Causes Control 2, 291–297 (1991). https://doi.org/10.1007/BF00051668
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DOI: https://doi.org/10.1007/BF00051668