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Cell-contact and-architecture of malignant cells and their relationship to metastasis

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Summary

The interaction of metastatic cells with the host environment occurs, to a large extent, through the cell surface, and the cell cytoskeletal system controls the distribution and motility of cell surface receptors. During metastasis, tumor cells migrate from one organ to another, and the dynamic properties and mechanochemical deformability of disseminated cells play a central role in the process. The studies described hereunder suggest an interrelationship between the cytoskeleton and cell adhesion, which can control and uagment the expression of the metastatic phenotype of neoplastic cells.

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References

  1. Poste G, Fidler IJ: The pathogenesis of cancer metastasis. Nature 283: 138–146, 1980

    Google Scholar 

  2. Nicolson GL: Cancer metastasis: Organ colonization and the cell surface properties of malignant cells. Biochim. Biophys Acta 495: 113–176, 1982

    Google Scholar 

  3. Fidler IJ: The evolution of biological heterogeneity in metastatic neoplasma. In: Nicolson GL and Milas L (eds) Cancer invasion and metastasis: Biological and therapeutic Aspects. Raven Press, New York, 1984, pp 5–26

    Google Scholar 

  4. Weiss L, Ward PM: Cell detachment and metastasis. Cancer Metastasis Rev 2: 111–124, 1983

    Google Scholar 

  5. Strauli P, Weiss L: Cell locomotion and tumor penetration. Eur J Cancer 13: 1–12, 1977

    Google Scholar 

  6. Scanlon EF, Volkner DD, Oviedo MA, Khandekar JD, Victor TA: Metastatic basal cell carcinoma. J Surg Onc 15: 171–180, 1980

    Google Scholar 

  7. Fidler IJ: The relationship of embolic hemogeneity, number, size and viability to the incidence of experimental metastasis. Eur J Cancer 9: 223–227, 1973

    Google Scholar 

  8. Gasic GJ, Gasic TB, Galanti N, Johnson T, Murphy S: Platelet tumor cell interaction in mice. The role of platelets in the spread of malignant disease. Int J Cancer 11: 704–718, 1973

    Google Scholar 

  9. Liotta LA, Kleinerman J, Saidel GM: The significance of hematogenous tumor cell clumps in the metastatic process. Cancer Res 36: 889–894, 1976

    Google Scholar 

  10. Raz A, Bucana C, McLellan W, Fidler IJ: Distribution of membrane anionic sites on B16 melanoma variants with differing lung colonization potential. Nature (Lond) 284: 363–364, 1980

    Google Scholar 

  11. Raz A, Lotan R: Lectin-like activities associated with human and murine neoplastic cells. Cancer Res 41: 3642–3647, 1981

    Google Scholar 

  12. Paget S: The distribution of secondary growths of cancer of the breast. Lancet 1: 571–573, 1889

    Google Scholar 

  13. Patel JK, Didolkar MS, Pickren JW, Moore RH: Metastatic pattern of malignant melanoma. Am J Surg 135: 807–810, 1978

    Google Scholar 

  14. Willis RA: The spread of tumors in the human body. London, Butterworths, 1973

    Google Scholar 

  15. Branson KW, Beattie G, Nicolson GL: Selection and altered properties of brain-colonizing metastatic melanoma. Nature (Lond) 272: 543–545, 1978

    Google Scholar 

  16. Fidler IJ, Nicolson GL: Organ sensitivity for implantation survival and growth of B16 melanoma variant tumor lines. J Natl Cancer Inst 57: 1199–1201, 1976

    Google Scholar 

  17. Raz A, Hart IR: Murine melanoma: a model for intracranial metastasis. Br J Cancer 66: 183–189, 1980

    Google Scholar 

  18. Shearman PJ, Longenecker BM: Clonal variation and functional correlation of organ-specific metastasis and an organ-specific metastasis-associated antigen. Int J Cancer 27: 387–395, 1981

    Google Scholar 

  19. Tao T, Matter A, Vogel R, Burger MM: Liver-colonizing melanoma cells selected from B16 melanoma. Int J Cancer 23: 854–957, 1979

    Google Scholar 

  20. Kramer RH, Nicolson GL: Interactions of tumor cells with vascular endothelial cell monolayers: a model for metastatic invasion. Proc Natl Acad Sci USA 76: 5704–5708, 1979

    Google Scholar 

  21. Nicolson GL, Irimura T, Gonzalez R, Ruoslahti E: The role of fibronectin in adhesion of metastatic melanoma cells to endothelial cells and their basal lamina. Exp Cell Res 135: 461–465, 1981

    Google Scholar 

  22. Warren BA, Vales O: The adhesion of thromboplastic tumor emboli to vessels in vitro. Br J Exp Pathol 53: 301–313, 1972

    Google Scholar 

  23. Raz A, Geiger B: Altered organization of cell-substrate contacts and membrane-associated cytoskeleton in tumor cell variants exhibiting different metastatic capabilities. Cancer Res 42: 5183–5190, 1982

    Google Scholar 

  24. Volk T, Geiger B, Raz A: Motility and adhesive properties of high-and low-metastatic neoplastic cells. Cancer Res 44: 811–824, 1984

    Google Scholar 

  25. Geiger B, Volk T, Raz A: Cell contacts and cytoskeletal organization of metastatic cell variants. Ex Biol Med 10: 39–53, 1985

    Google Scholar 

  26. Zvibel I, Raz A: The establishment and characterization of a new BALB/c angiosarcoma tumor system. Int J Cancer 36: 261–272, 1985

    Google Scholar 

  27. Netland PA, Zetter BR: Metastatic potential of B16 melanoma cells after in vitro selection for organ-specific adherence. J Cell Biol 101: 720–724, 1985

    Google Scholar 

  28. McCarthy JB, Basara ML, Palm SL, Sas F, Furcht LT: The role of cell adhesion proteins—laminin and fibronectin—in the movement of malignant and metastatic cells. Cancer Met Rev 4: 125–152, 1985

    Google Scholar 

  29. Albrecht-Buehler G: The phagokinetic tracks of 3T3 cells. Cell 11: 395–404, 1977

    Google Scholar 

  30. Young RM, Newby M, Meunier J: Relationships between morphology, dissemination, migration, and prostaglandin E2 secretion by cloned variants of Lewis lung carcinoma. Cancer Res 45: 3918–3923, 1985

    Google Scholar 

  31. Badenoch-Jones P, Ramshaw IA: Spontaneous capillary tube migration of metastatic rat mammary adenocarcinoma cells. Invasion and Metastasis 4: 98–110, 1984

    Google Scholar 

  32. Stoker M, O'Neill CH, Berryman S, Waxman V: Anchorage and growth regulation in normal and virus-transformed cells. Int J Cancer 3: 683–693, 1968

    Google Scholar 

  33. Otsuka H, Moskowitz M: Arrest of 3T3 cells in G1 phase in suspension culture. J Cell Physiol 87: 213–220, 1975

    Google Scholar 

  34. Maroudas NG: Growth of fibroblasts on linear and planar anchorage of limiting dimensions. Exp Cell Res 81: 104–110, 1973

    Google Scholar 

  35. Folkman J, Moscona A: Role of cell shape in growth control. Nature 273: 345–349, 1978

    Google Scholar 

  36. Vasiliev JM: Spreading of non-transformed and transformed cells. Biochim Biophys Acta 780: 21–65, 1985

    Google Scholar 

  37. Folkman J, Greenspan HP: Influence of geometry on control of cell growth. Biochim Biophys Acta 417: 211–236, 1975

    Google Scholar 

  38. Brouty-Boye D, Tucker RW, Folkman J: Transformed and neoplastic phenotype reversibility during culture by cell density and cell shape. Int J Cancer 26: 501–507, 1980

    Google Scholar 

  39. Wittelsberger SC, Kleene K, Penman S: Progressive loss of shaperesponsive metabolic controls in cells with increasingly transformed phenotype. Cell 24: 859–866, 1981

    Google Scholar 

  40. Raz A, Ben-Ze'ev A: Growth control and cell spreading differential response in preneoplastic and metastatic cell variants. Int J Cancer 29: 711–715, 1982

    Google Scholar 

  41. Ben-Ze'ev A, Farmer SR, Penman S: Protein synthesis requires cellsurface contact while nuclear events respond to cell shape in anchorgedependent fibroblasts. Cell 21: 365–372 1980

    Google Scholar 

  42. Raz A, Ben-Ze'ev A: Modulation of the metastatic capability in B16 melanoma by cell shape. Science 221: 1307–1310, 1983

    Google Scholar 

  43. Poste G: Tumor cell heterogeneity and the metastatic process. In: Rich MA, Hager J, Furmanski P (eds) Understanding breast cancer. Clinical and laboratory concepts. Marcel Decker Inc New York, 1983, pp 119–143

    Google Scholar 

  44. Schirrmacher V: Shifts in tumor cell phenotypes induced by signals from the microenvironment. Relevance for the immunobiology of cancer metastasis. Immunobiol 157: 89–98, 1980

    Google Scholar 

  45. Stackpole CW, Fornabaio DM, Alterman AL: Phenotypic interconversion of B16 melanoma clonal cell population: Relationship between metastasis and tumor growth rate. Int J Cancer 35: 667–674, 1985

    Google Scholar 

  46. Takenaga K: Enhanced metastatic potential of cloned lowmetastatic Lewis lung carcinoma cells treated in vitro with dimethyl sulfoxide. Cancer Res 44: 1122–1127, 1984

    Google Scholar 

  47. Shiu RP, Paterson JA: Alteration of cell shape adhesion, and lipid accumulation in human breast cancer cells (T-4D7) by human prolactin and growth hormone. Cancer Res 44: 1178–1186, 1984

    Google Scholar 

  48. Nicolson GL, Fidler IJ, Poste G: Effects of tertiary amine local anesthetics on blood-borne implantation and cell surface properties of metastatic mouse melanoma cells. J Natl Cancer Inst 76: 511–519, 1986

    Google Scholar 

  49. Hochman Y, Katz A, Levy E, Eshel S: Substrate-adhering lymphoid cells show impaired tumorigenicity and increased immunogenicity. Nature (Lond) 290: 248–249, 1981

    Google Scholar 

  50. Fogel M, Altevogt P, Schirmacher V: Metastatic potential severely altered by changes in tumor cell adhesiveness and cell-surface sialylation. J Exp Med 157: 371–376, 1983

    Google Scholar 

  51. Matzku S, Komitowski D, Mildenberger M, Zoller M: Characterization of BSp73, a spontaneous rat tumor and its in vivo selected variants showing different metastasizing capacities. Invasion Metastasis 3: 109–123, 1983

    Google Scholar 

  52. Raz A, Zoller M, Ben-Ze'ev A: Cell configuration and adhesive properties of metastasizing and non metastasizing BSp73 rat adenocarcinoma cells. Exp Cell Res 162: 127–141, 1986

    Google Scholar 

  53. Lotan R, Raz A: Metastatic melanoma cells selected for reduced homotypic aggregation capability exhibited low colony formation in vivo and in culture. Cancer Res 43: 2088–2093, 1983

    Google Scholar 

  54. The Cell in Contact. Edelman GM (ed) UCLA Symposia on Molecular and Cellular Biology. Alan R Liss, New York, 1985 (31)

    Google Scholar 

  55. Obrink B: Epithelial cell adhesion molecules. Exp Cell Res 163: 1–21, 1986

    Google Scholar 

  56. Crossin KL, Carney DH: Evidence that microtubule depolymerization early in the cell cycle is sufficient to initiate DNA synthesis. Cell 23: 61–71, 1981

    Google Scholar 

  57. Maness PF, Walsh RC: Dihydrocytochalasin B disorganizes actin cytoarchitecture and inhibits initiation of DNA synthesis in 3T3 cells. Cell 30: 253–262, 1982

    Google Scholar 

  58. Bockus BJ, Stiles CD: Regulation of cytoskeletal architecture by platelet-derived growth factor, insulin and epidermal growth factor. Exp Cell Res 153: 186–197, 1984

    Google Scholar 

  59. Herman B, Pledger WJ: Platelet-derived growth factorinduced alterations in vinculin and actin distribution in Balb/c-3T3 cells. J Cell Biol 100: 1031–1040, 1985

    Google Scholar 

  60. Ben-Ze'ev A: The cytoskeleton in cancer cells. Biochim biophys Acta 780: 197–212, 1985

    Google Scholar 

  61. Hagmar B, Ryd W: Tumor cell locomotion: a factor in metastasis formation? Influence of cytochalasin B on a tumor dissemination pattern. Int J Cancer 19: 576–580, 1977

    Google Scholar 

  62. Hart IR, Raz A, Fidler IJ: Effect of cytoskeleton-disrupting agents on the metastatic behavior of melanoma cells. J Natl Cancer Inst 64: 891–900, 1980

    Google Scholar 

  63. Zachary JM, Cleveland G, Kwock L, Lawrence T, Weissmann RM, Nabell L, Fried FA, Staub EV, Risinger MA, Lin S: Actin filament organization of the Dunning R337 rat prostatic adenocarcinoma system: Correlation with metastatic potential. Cancer Res 46: 926–932, 1986

    Google Scholar 

  64. Friedman E, Verderame M, Winawer S, Pollack R: Actin cytoskeletal organization loss in the benign-to-malignant tumor transition in cultured human colonic epithelial cells. Cancer Res 44: 3040–3050, 1984

    Google Scholar 

  65. Geiger B: A 130-K protein from chicken gizzard: its localization at the termini of microfilament bundles in cultured chicken cells. Cell 18: 193–205, 1979

    Google Scholar 

  66. Geiger B: Membrane-cytoskeleton interaction. Biochim Biophys Acta 737: 305–341, 1983

    Google Scholar 

  67. Bubenik J, Perlmann P, Fenyo EM, Jandlova T, Schajova E, Malkovsky M: Inverse correlation between cell-surface adhesiveness and malignancy in mouse fibroblastoid cell lines. Int J Cancer 23: 392–396, 1979

    Google Scholar 

  68. Reich S, Rosin H, Levy M, Karkash R, Raz A: Cellsubstrate interaction: a method for evaluating the possible correlation between metastatic phenotype and cell surface energy. Exp Cell Res 153: 556–460, 1984

    Google Scholar 

  69. Intermediate Filaments. Wang E, Fischman D, Liem RKH, Sun T-T (eds) Ann N Y Acad Sci 455: 1–829, 1985

  70. Osborn M, Weber K: Intermediate filaments: cell-type-specific markers in differentiation and pathology. Cell 31: 303–306, 1982

    Google Scholar 

  71. Osborn M, Weber K: Tumor diagnosis by intermediate filament typing: a novel tool for surgical pathology. Lab Invest 48: 372–397, 1983

    Google Scholar 

  72. Ben-Ze'ev A: Cell configuration related control of vimentin biosynthesis and phosphorylation in cultured mammalian cells. J Cell Biol 97: 858–865, 1983

    Google Scholar 

  73. Bernal SD, Baylin SB, Shaper JH, Gardar AF, Chen LB: Cytoskeletal-associated proteins of human lung cancer cells. Cancer Res 43: 1798–1808, 1983

    Google Scholar 

  74. Ben-Ze'ev A, Raz A: The relationship between the organisation and synthesis of vimentin and the metastatic capability of B16 melanoma cells. Cancer Res 45: 2632–2641, 1985

    Google Scholar 

  75. Ben-Ze'ev A, Zoller M, Raz A: Differential expression of intermediate filament proteins in metastatic and non metastatic variants of the BSp73 tumor. Cancer Res 46: 785–790, 1986

    Google Scholar 

  76. Connell ND, Rheinwald JG: Regulation of cytoskeletal composition in mesothelial cells: reversible loss of keratin and increase in vimentin during rapid growth in culture. Cell 34: 245–253, 1983

    Google Scholar 

  77. LaRocca PJ, Rheinwald JG: Coexpression of simple epithelial keratins and vimentin by human mesothelium and mesothelioma in vivo and in culture. Cancer Res 44: 2991–2999, 1984

    Google Scholar 

  78. Gunther A, Kinjo M, Winter H, Sonka J, Volm M: Differential expression of intermediate-filament proteins in murine sarcoma 180 ascites or solid tumor. Cancer Res 44: 2590–2594, 1984

    Google Scholar 

  79. Kinjo M, Winter H, Schweizer J: Differential expression of intermediate filament proteins in two rat ascites hepatoma lines of common origin. Carcinogenesis 5: 1249–1255, 1984

    Google Scholar 

  80. Ramaekers FCS, Haag D, Kant A, Moesker O, Jap PHK, Vooijs GP: Coexpression of keratin-and vimentin-type intermediate filaments in human metastatic carcinoma cells. Proc Natl Acad Sci USA 80: 2618–2622, 1983

    Google Scholar 

  81. Virtanen I, Lehto V-P, Lehtonen E, Vartio T, Stenman S, Kurki P, Wagner O, Small JV, Dahl D, Bradley RA: Expression of intermediate filaments in cultured cells. J Cell Sci 50: 45–63, 1981

    Google Scholar 

  82. Lane EB, Hogan BLM, Kurkinen M, Garrels JI: Co-expression of vimentin and cytokeratins in parietal endoderm cells of early mouse embryo. Nature (Lond) 303: 701–704, 1983

    Google Scholar 

  83. Summerhayes IC, Cheng Y-S, Sun T-T, Chen LB: Expression of keratin and vimentin intermediate filaments in rabbit bladder epithelial cells at different stages of benzo(a)pyrene-induced neoplastic progression. J Cell Biol 90: 63–69, 1981

    Google Scholar 

  84. Ben-Ze'ev A: Differential control of cytokeratins and vimentin synthesis by cell-cell contact and cell spreading in cultured epithelial cells. J Cell Biol 99: 1424–1433, 1984

    Google Scholar 

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Authors and Affiliations

  1. Department of Cell Biology, Weizmann Institute of Science, 76100, Rehovot, Israel

    Avraham Raz

  2. Department of Genetics, Weizmann Institute of Science, 76100, Rehovot, Israel

    Avri Ben-Ze'ev

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  1. Avraham Raz
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  2. Avri Ben-Ze'ev
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Raz, A., Ben-Ze'ev, A. Cell-contact and-architecture of malignant cells and their relationship to metastasis. Cancer Metast Rev 6, 3–21 (1987). https://doi.org/10.1007/BF00047606

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