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Lipid Metabolism in Tumor-Associated Macrophages

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Lipid Metabolism in Tumor Immunity

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1316))

Abstract

Macrophages are essential components of the immune system in tumors. It can be recruited and educated to two mainly polarized subpopulations (M1-like and M2-like) of tumor-associated macrophages (TAMs) to display anti-tumor or protumor function during the tumor occurrence and progression. Reprogramming of metabolism, especially lipid metabolism, is a typical characteristic of TAMs polarization, which was confirmed recently as a vital target for tumor therapy. However, the relationship between TAMs and lipid metabolism is still obscure in the past decade. In this review, we will first introduce the historical aspects of TAMs, and then discuss the correlation of main lipids (triglycerides, cholesterol, and phospholipids) to TAMs activation and summarize the mechanisms by which lipid metabolism mediated tumor escape the immunological surveillance as well as currently available drugs targeting these mechanisms. We hope that this chapter will give a better understanding of lipid metabolism in TAMs for those who are interested in this field, and lay a foundation to develop novel strategies for tumor therapy by targeting lipid metabolism.

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Authors and Affiliations

  1. Department of Biochemistry and Molecular Biology, Third Military Medical University (Army Medical University), Chongqing, People’s Republic of China

    Yuancai Xiang & Hongming Miao

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  1. Yuancai Xiang
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  2. Hongming Miao
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  1. Department of Medical Oncology, Chongqing University Cancer Hospital, Chongqing, China

    Yongsheng Li

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Xiang, Y., Miao, H. (2021). Lipid Metabolism in Tumor-Associated Macrophages. In: Li, Y. (eds) Lipid Metabolism in Tumor Immunity. Advances in Experimental Medicine and Biology, vol 1316. Springer, Singapore. https://doi.org/10.1007/978-981-33-6785-2_6

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