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Mass Spectrometry-based Metabolomics in Translational Research

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Advanced Imaging and Bio Techniques for Convergence Science

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1310))

Abstract

Metabolomics is the systematic study of metabolite profiles of complex biological systems, and involves the systematic identification and quantification of metabolites. Metabolism is integrated with all biochemical reactions in biological systems; thus metabolite profiles provide collective information on biochemical processes induced by genetic or environmental perturbations. Transcriptomes or proteomes may not be functionally active and not always reflect phenotypic variations. The metabolome, however, consists of the biomolecules closest to the phenotype of living organisms, and is often called the molecular phenotype of biological systems. Thus, metabolome alterations can easily result in disease states, providing important clues to understand pathophysiological mechanisms contributing to various biomedical symptoms. The metabolome and metabolomics have been emphasized in translational research related to biomarker discovery, drug target discovery, drug responses, and disease mechanisms. This review describes the basic concepts, workflows, and applications of mass spectrometry-based metabolomics in translational research.

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Acknowledgments

This study was supported by a grant (2018IL0540, 2019IL0540) from the Asan Institute of Life Sciences, Asan Medical Center, Seoul and by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (2019R1F1A1056286).

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The authors declare no competing interests relevant to this chapter.

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  1. Department of Convergence Medicine, Asan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea

    Su Jung Kim, Ha Eun Song, Hyo Yeong Lee & Hyun Ju Yoo

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Correspondence to Hyun Ju Yoo .

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  1. Department of Convergence Medicine, University of Ulsan College of Medicine, Asan Institute for Life Sciences, Asan Medical Center, Seoul, Korea (Republic of)

    Jun Ki Kim

  2. Department of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea (Republic of)

    Jeong Kon Kim

  3. Department of Convergence Medicine, University of Ulsan College of Medicine, Asan Institute for Life Sciences, Asan Medical Center, Seoul, Korea (Republic of)

    Chan-Gi Pack

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Kim, S.J., Song, H.E., Lee, H.Y., Yoo, H.J. (2021). Mass Spectrometry-based Metabolomics in Translational Research. In: Kim, J.K., Kim, J.K., Pack, CG. (eds) Advanced Imaging and Bio Techniques for Convergence Science. Advances in Experimental Medicine and Biology, vol 1310. Springer, Singapore. https://doi.org/10.1007/978-981-33-6064-8_19

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