Abstract
This chapter will focus on task magnetic resonance imaging (MRI) to understand the biological mechanisms and pathophysiology of brain in major depressive disorder (MDD), which would have minor alterations in the brain function. Therefore, the functional study, such as task MRI functional connectivity, would play a crucial role to explore the brain function in MDD. Different kinds of tasks would determine the alterations in functional connectivity in task MRI studies of MDD. The emotion-related tasks are linked with alterations in anterior cingulate cortex, insula, and default mode network. The emotional memory task is linked with amygdala-hippocampus alterations. The reward-related task would be related to the reward circuit alterations, such as fronto-straital. The cognitive-related tasks would be associated with frontal-related functional connectivity alterations, such as the dorsolateral prefrontal cortex, anterior cingulate cortex, and other frontal regions. The visuo-sensory characteristics of tasks might be associated with the parieto-occipital alterations. The frontolimbic regions might be major components of task MRI-based functional connectivity in MDD. However, different scenarios and tasks would influence the representations of results.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Similar content being viewed by others
References
Sheline YI (2000) 3D MRI studies of neuroanatomic changes in unipolar major depression: the role of stress and medical comorbidity. Biol Psychiatry 48(8):791–800
Sheline YI, Barch DM, Price JL, Rundle MM, Vaishnavi SN, Snyder AZ et al (2009) The default mode network and self-referential processes in depression. Proc Natl Acad Sci U S A 106(6):1942–1947
Comte M, Schon D, Coull JT, Reynaud E, Khalfa S, Belzeaux R et al (2016) Dissociating bottom-up and top-down mechanisms in the cortico-limbic system during emotion processing. Cereb Cortex 26(1):144–155
Lai CH (2019) The neural markers of MRI to differentiate depression and panic disorder. Prog Neuro-Psychopharmacol Biol Psychiatry 91:72–78
Matthews SC, Strigo IA, Simmons AN, Yang TT, Paulus MP (2008) Decreased functional coupling of the amygdala and supragenual cingulate is related to increased depression in unmedicated individuals with current major depressive disorder. J Affect Disord 111(1):13–20
Frodl T, Bokde AL, Scheuerecker J, Lisiecka D, Schoepf V, Hampel H et al (2010) Functional connectivity bias of the orbitofrontal cortex in drug-free patients with major depression. Biol Psychiatry 67(2):161–167
Opel N, Redlich R, Grotegerd D, Dohm K, Zaremba D, Meinert S et al (2017) Prefrontal brain responsiveness to negative stimuli distinguishes familial risk for major depression from acute disorder. J Psychiatry Neurosci: JPN 42(5):343–352
Moses-Kolko EL, Perlman SB, Wisner KL, James J, Saul AT, Phillips ML (2010) Abnormally reduced dorsomedial prefrontal cortical activity and effective connectivity with amygdala in response to negative emotional faces in postpartum depression. Am J Psychiatry 167(11):1373–1380
Gorka AX, Knodt AR, Hariri AR (2015) Basal forebrain moderates the magnitude of task-dependent amygdala functional connectivity. Soc Cogn Affect Neurosci 10(4):501–507
Carballedo A, Scheuerecker J, Meisenzahl E, Schoepf V, Bokde A, Moller HJ et al (2011) Functional connectivity of emotional processing in depression. J Affect Disord 134(1–3):272–279
Robinson OJ, Overstreet C, Allen PS, Letkiewicz A, Vytal K, Pine DS et al (2013) The role of serotonin in the neurocircuitry of negative affective bias: serotonergic modulation of the dorsal medial prefrontal-amygdala ‘aversive amplification’ circuit. NeuroImage 78:217–223
Westlund Schreiner M, Klimes-Dougan B, Mueller BA, Eberly LE, Reigstad KM, Carstedt PA et al (2017) Multi-modal neuroimaging of adolescents with non-suicidal self-injury: amygdala functional connectivity. J Affect Disord 221:47–55
Dannlowski U, Ohrmann P, Konrad C, Domschke K, Bauer J, Kugel H et al (2009) Reduced amygdala-prefrontal coupling in major depression: association with MAOA genotype and illness severity. Int J Neuropsychopharmacol/Off Sci J Coll Int Neuropsychopharmacologicum 12(1):11–22
Goulden N, McKie S, Thomas EJ, Downey D, Juhasz G, Williams SR et al (2012) Reversed frontotemporal connectivity during emotional face processing in remitted depression. Biol Psychiatry 72(7):604–611
Harrison NA, Brydon L, Walker C, Gray MA, Steptoe A, Critchley HD (2009) Inflammation causes mood changes through alterations in subgenual cingulate activity and mesolimbic connectivity. Biol Psychiatry 66(5):407–414
Li J, Kale Edmiston E, Tang Y, Fan G, Xu K, Wang F et al (2018) Shared facial emotion processing functional network findings in medication-naive major depressive disorder and healthy individuals: detection by sICA. BMC Psychiatry 18(1):96
Loeffler LAK, Radke S, Habel U, Ciric R, Satterthwaite TD, Schneider F et al (2018) The regulation of positive and negative emotions through instructed causal attributions in lifetime depression – a functional magnetic resonance imaging study. NeuroImage Clin 20:1233–1245
Luo L, Becker B, Zheng X, Zhao Z, Xu X, Zhou F et al (2018) A dimensional approach to determine common and specific neurofunctional markers for depression and social anxiety during emotional face processing. Hum Brain Mapp 39(2):758–771
Lisiecka DM, Carballedo A, Fagan AJ, Ferguson Y, Meaney J, Frodl T (2013) Recruitment of the left hemispheric emotional attention neural network in risk for and protection from depression. J Psychiatry Neurosci: JPN 38(2):117–128
Ho TC, Yang G, Wu J, Cassey P, Brown SD, Hoang N et al (2014) Functional connectivity of negative emotional processing in adolescent depression. J Affect Disord 155:65–74
Park CH, Wang SM, Lee HK, Kweon YS, Lee CT, Kim KT et al (2014) Affective state-dependent changes in the brain functional network in major depressive disorder. Soc Cogn Affect Neurosci 9(9):1404–1412
Miskowiak KW, Glerup L, Vestbo C, Harmer CJ, Reinecke A, Macoveanu J et al (2015) Different neural and cognitive response to emotional faces in healthy monozygotic twins at risk of depression. Psychol Med 45(7):1447–1458
Shapero BG, Chai XJ, Vangel M, Biederman J, Hoover CS, Whitfield-Gabrieli S et al (2019) Neural markers of depression risk predict the onset of depression. Psychiatry Res Neuroimaging 285:31–39
Rosa MJ, Portugal L, Hahn T, Fallgatter AJ, Garrido MI, Shawe-Taylor J et al (2015) Sparse network-based models for patient classification using fMRI. NeuroImage 105:493–506
Cullen KR, Klimes-Dougan B, Vu DP, Westlund Schreiner M, Mueller BA, Eberly LE et al (2016) Neural correlates of antidepressant treatment response in adolescents with major depressive disorder. J Child Adolesc Psychopharmacol 26(8):705–712
Wong NM, Liu HL, Lin C, Huang CM, Wai YY, Lee SH et al (2016) Loneliness in late-life depression: structural and functional connectivity during affective processing. Psychol Med 46(12):2485–2499
Albert K, Gau V, Taylor WD, Newhouse PA (2017) Attention bias in older women with remitted depression is associated with enhanced amygdala activity and functional connectivity. J Affect Disord 210:49–56
Price RB, Lane S, Gates K, Kraynak TE, Horner MS, Thase ME et al (2017) Parsing heterogeneity in the brain connectivity of depressed and healthy adults during positive mood. Biol Psychiatry 81(4):347–357
Erk S, Mikschl A, Stier S, Ciaramidaro A, Gapp V, Weber B et al (2010) Acute and sustained effects of cognitive emotion regulation in major depression. J Neurosci Off J Soc Neurosci 30(47):15726–15734
Light SN, Heller AS, Johnstone T, Kolden GG, Peterson MJ, Kalin NH et al (2011) Reduced right ventrolateral prefrontal cortex activity while inhibiting positive affect is associated with improvement in hedonic capacity after 8 weeks of antidepressant treatment in major depressive disorder. Biol Psychiatry 70(10):962–968
Perlman G, Simmons AN, Wu J, Hahn KS, Tapert SF, Max JE et al (2012) Amygdala response and functional connectivity during emotion regulation: a study of 14 depressed adolescents. J Affect Disord 139(1):75–84
Grant MM, White D, Hadley J, Hutcheson N, Shelton R, Sreenivasan K et al (2014) Early life trauma and directional brain connectivity within major depression. Hum Brain Mapp 35(9):4815–4826
Yamamoto T, Toki S, Siegle GJ, Takamura M, Takaishi Y, Yoshimura S et al (2017) Increased amygdala reactivity following early life stress: a potential resilience enhancer role. BMC Psychiatry 17(1):27
Fitzgerald JM, Klumpp H, Langenecker S, Phan KL (2019) Transdiagnostic neural correlates of volitional emotion regulation in anxiety and depression. Depress Anxiety 36(5):453–464
Walsh EC, Eisenlohr-Moul TA, Minkel J, Bizzell J, Petty C, Crowther A et al (2019) Pretreatment brain connectivity during positive emotion upregulation predicts decreased anhedonia following behavioral activation therapy for depression. J Affect Disord 243:188–192
Berman MG, Peltier S, Nee DE, Kross E, Deldin PJ, Jonides J (2011) Depression, rumination and the default network. Soc Cogn Affect Neurosci 6(5):548–555
Shi H, Wang X, Yi J, Zhu X, Zhang X, Yang J et al (2015) Default mode network alterations during implicit emotional faces processing in first-episode, treatment-naive major depression patients. Front Psychol 6:1198
Horne CM, Norbury R (2018) Late chronotype is associated with enhanced amygdala reactivity and reduced fronto-limbic functional connectivity to fearful versus happy facial expressions. NeuroImage 171:355–363
Wagner G, Koch K, Schachtzabel C, Peikert G, Schultz CC, Reichenbach JR et al (2013) Self-referential processing influences functional activation during cognitive control: an fMRI study. Soc Cogn Affect Neurosci 8(7):828–837
Etkin A, Schatzberg AF (2011) Common abnormalities and disorder-specific compensation during implicit regulation of emotional processing in generalized anxiety and major depressive disorders. Am J Psychiatry 168(9):968–978
Fournier JC, Chase HW, Greenberg T, Etkin A, Almeida JR, Stiffler R et al (2017) Neuroticism and individual differences in neural function in unmedicated major depression: findings from the EMBARC study. Biol Psychiatry:Cogn Neurosci Neuroimaging 2(2):138–148
van Tol MJ, Veer IM, van der Wee NJ, Aleman A, van Buchem MA, Rombouts SA et al (2013) Whole-brain functional connectivity during emotional word classification in medication-free major depressive disorder: abnormal salience circuitry and relations to positive emotionality. NeuroImage Clin 2:790–796
Ho TC, Connolly CG, Henje Blom E, LeWinn KZ, Strigo IA, Paulus MP et al (2015) Emotion-dependent functional connectivity of the default mode network in adolescent depression. Biol Psychiatry 78(9):635–646
Tozzi L, Doolin K, Farrel C, Joseph S, O’Keane V, Frodl T (2017) Functional magnetic resonance imaging correlates of emotion recognition and voluntary attentional regulation in depression: a generalized psycho-physiological interaction study. J Affect Disord 208:535–544
Leal SL, Noche JA, Murray EA, Yassa MA (2017) Disruption of amygdala-entorhinal-hippocampal network in late-life depression. Hippocampus 27(4):464–476
Spies M, Kraus C, Geissberger N, Auer B, Klobl M, Tik M et al (2017) Default mode network deactivation during emotion processing predicts early antidepressant response. Transl Psychiatry 7(1):e1008
Zhang B, Li S, Zhuo C, Li M, Safron A, Genz A et al (2017) Altered task-specific deactivation in the default mode network depends on valence in patients with major depressive disorder. J Affect Disord 207:377–383
Hulvershorn LA, Cullen K, Anand A (2011) Toward dysfunctional connectivity: a review of neuroimaging findings in pediatric major depressive disorder. Brain Imaging Behav 5(4):307–328
Rive MM, van Rooijen G, Veltman DJ, Phillips ML, Schene AH, Ruhe HG (2013) Neural correlates of dysfunctional emotion regulation in major depressive disorder. A systematic review of neuroimaging studies. Neurosci Biobehav Rev 37(10 Pt 2):2529–2553
Matsuo K, Glahn DC, Peluso MA, Hatch JP, Monkul ES, Najt P et al (2007) Prefrontal hyperactivation during working memory task in untreated individuals with major depressive disorder. Mol Psychiatry 12(2):158–166
Bartova L, Meyer BM, Diers K, Rabl U, Scharinger C, Popovic A et al (2015) Reduced default mode network suppression during a working memory task in remitted major depression. J Psychiatr Res 64:9–18
Le TM, Borghi JA, Kujawa AJ, Klein DN, Leung HC (2017) Alterations in visual cortical activation and connectivity with prefrontal cortex during working memory updating in major depressive disorder. NeuroImage Clin 14:43–53
Rodriguez-Cano E, Alonso-Lana S, Sarro S, Fernandez-Corcuera P, Goikolea JM, Vieta E et al (2017) Differential failure to deactivate the default mode network in unipolar and bipolar depression. Bipolar Disord 19(5):386–395
Schlosser RG, Wagner G, Koch K, Dahnke R, Reichenbach JR, Sauer H (2008) Fronto-cingulate effective connectivity in major depression: a study with fMRI and dynamic causal modeling. NeuroImage 43(3):645–655
Spielberg JM, Miller GA, Warren SL, Sutton BP, Banich M, Heller W (2014) Transdiagnostic dimensions of anxiety and depression moderate motivation-related brain networks during goal maintenance. Depress Anxiety 31(10):805–813
Vasic N, Walter H, Sambataro F, Wolf RC (2009) Aberrant functional connectivity of dorsolateral prefrontal and cingulate networks in patients with major depression during working memory processing. Psychol Med 39(6):977–987
Rao JA, Kassel MT, Weldon AL, Avery ET, Briceno EM, Mann M et al (2015) The double burden of age and major depressive disorder on the cognitive control network. Psychol Aging 30(2):475–485
Ho TC, Sacchet MD, Connolly CG, Margulies DS, Tymofiyeva O, Paulus MP et al (2017) Inflexible functional connectivity of the dorsal anterior cingulate cortex in adolescent major depressive disorder. Neuropsychopharmacology 42(12):2434–2445
Tozzi L, Goldstein-Piekarski AN, Korgaonkar MS, Williams LM (2019) Connectivity of the cognitive control network during response inhibition as a predictive and response biomarker in major depression: evidence from a randomized clinical trial. Biol Psychiatry 21:462
Desseilles M, Schwartz S, Dang-Vu TT, Sterpenich V, Ansseau M, Maquet P et al (2011) Depression alters “top-down” visual attention: a dynamic causal modeling comparison between depressed and healthy subjects. NeuroImage 54(2):1662–1668
Dai Q, Yin X, Li H, Feng Z (2018) Orbito-frontal cortex mechanism of inhibition of return in current and remitted depression. Hum Brain Mapp 39(7):2941–2954
Yang Z, Oathes DJ, Linn KA, Bruce SE, Satterthwaite TD, Cook PA et al (2018) Cognitive behavioral therapy is associated with enhanced cognitive control network activity in major depression and posttraumatic stress disorder. Biol Psychiatry: Cogn Neurosci Neuroimaging 3(4):311–319
Smoski MJ, Rittenberg A, Dichter GS (2011) Major depressive disorder is characterized by greater reward network activation to monetary than pleasant image rewards. Psychiatry Res 194(3):263–270
Admon R, Nickerson LD, Dillon DG, Holmes AJ, Bogdan R, Kumar P et al (2015) Dissociable cortico-striatal connectivity abnormalities in major depression in response to monetary gains and penalties. Psychol Med 45(1):121–131
Admon R, Kaiser RH, Dillon DG, Beltzer M, Goer F, Olson DP et al (2017) Dopaminergic enhancement of striatal response to reward in major depression. Am J Psychiatry 174(4):378–386
Dichter GS, Kozink RV, McClernon FJ, Smoski MJ (2012) Remitted major depression is characterized by reward network hyperactivation during reward anticipation and hypoactivation during reward outcomes. J Affect Disord 136(3):1126–1134
Walsh E, Carl H, Eisenlohr-Moul T, Minkel J, Crowther A, Moore T et al (2017) Attenuation of frontostriatal connectivity during reward processing predicts response to psychotherapy in major depressive disorder. Neuropsychopharmacology 42(4):831–843
Kumar P, Goer F, Murray L, Dillon DG, Beltzer ML, Cohen AL et al (2018) Impaired reward prediction error encoding and striatal-midbrain connectivity in depression. Neuropsychopharmacology 43(7):1581–1588
Tan A, Costi S, Morris LS, Van Dam NT, Kautz M, Whitton AE et al (2018) Effects of the KCNQ channel opener ezogabine on functional connectivity of the ventral striatum and clinical symptoms in patients with major depressive disorder. Mol Psychiatry 25:1323
Eckstrand KL, Hanford LC, Bertocci MA, Chase HW, Greenberg T, Lockovich J et al (2019) Trauma-associated anterior cingulate connectivity during reward learning predicts affective and anxiety states in young adults. Psychol Med 49(11):1831–1840
He Z, Zhang D, Muhlert N, Elliott R (2019) Neural substrates for anticipation and consumption of social and monetary incentives in depression. Soc Cogn Affect Neurosci 14(8):815–826
Strigo IA, Matthews SC, Simmons AN (2013) Decreased frontal regulation during pain anticipation in unmedicated subjects with major depressive disorder. Transl Psychiatry 3:e239
Avery JA, Drevets WC, Moseman SE, Bodurka J, Barcalow JC, Simmons WK (2014) Major depressive disorder is associated with abnormal interoceptive activity and functional connectivity in the insula. Biol Psychiatry 76(3):258–266
Admon R, Holsen LM, Aizley H, Remington A, Whitfield-Gabrieli S, Goldstein JM et al (2015) Striatal hypersensitivity during stress in remitted individuals with recurrent depression. Biol Psychiatry 78(1):67–76
Jones NP, Chase HW, Fournier JC (2016) Brain mechanisms of anxiety’s effects on cognitive control in major depressive disorder. Psychol Med 46(11):2397–2409
Young CB, Chen T, Nusslock R, Keller J, Schatzberg AF, Menon V (2016) Anhedonia and general distress show dissociable ventromedial prefrontal cortex connectivity in major depressive disorder. Transl Psychiatry 6:e810
Sambataro F, Visintin E, Doerig N, Brakowski J, Holtforth MG, Seifritz E et al (2017) Altered dynamics of brain connectivity in major depressive disorder at-rest and during task performance. Psychiatry Res Neuroimaging 259:1–9
Miller CH, Hamilton JP, Sacchet MD, Gotlib IH (2015) Meta-analysis of functional neuroimaging of major depressive disorder in youth. JAMA Psychiat 72(10):1045–1053
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2021 Springer Nature Singapore Pte Ltd.
About this chapter
Cite this chapter
Lai, CH. (2021). Task MRI-Based Functional Brain Network of Major Depression. In: Kim, YK. (eds) Major Depressive Disorder. Advances in Experimental Medicine and Biology, vol 1305. Springer, Singapore. https://doi.org/10.1007/978-981-33-6044-0_2
Download citation
DOI: https://doi.org/10.1007/978-981-33-6044-0_2
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-33-6043-3
Online ISBN: 978-981-33-6044-0
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)