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Interplay Between Nutrient-Sensing Molecules During Aging and Longevity

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Models, Molecules and Mechanisms in Biogerontology

Abstract

Apart from the genetic makeup that plays a fundamental role in health and lifespan determination of an organism, the environment largely influences aging and longevity. One of the environmental factors that determine the well-being of the animal and is involved in various degenerative processes associated with aging is nutrition. Nutritional status in the cell is detected by the interplay of a network of special molecules called nutrient-sensing molecules. These are factors that detect the changes in the nutrient availability of the system and, therefore, integrate various signaling pathways that alter the adaptability of the organism to the changing paradigm to maintain homeostasis. In this present chapter, we will discuss the various mechanisms of nutrient sensing and their interplay in controlling aging and longevity.

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Acknowledgments

Authors thank the Department of Biochemistry, North-Eastern Hill University, Shillong, for the research facilities. We thank the UGC-SAP program in Biochemistry, the DBT Infrastructure, and Biotech Hub to NEHU for financial support.

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  1. Ibanylla Kynjai Hynniewta Hadem and Teikur Majaw contributed equally with all other contributors.

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  1. Department of Biochemistry, North-Eastern Hill University, Shillong, Meghalaya, India

    Ibanylla Kynjai Hynniewta Hadem, Teikur Majaw & Ramesh Sharma

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    Pramod C. Rath

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Hadem, I.K.H., Majaw, T., Sharma, R. (2020). Interplay Between Nutrient-Sensing Molecules During Aging and Longevity. In: Rath, P. (eds) Models, Molecules and Mechanisms in Biogerontology. Springer, Singapore. https://doi.org/10.1007/978-981-32-9005-1_18

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