Abstract
The tremendous development of Additive Manufacturing (AM) made significant progress in biomedical and tissue engineering applications. AM has a smart manufacturing capability for building three dimensional (3D) complex geometries of biomedical implants with controlled process parameters and by utilizing innovative materials especially, functional biocomposites. The patient specific and customized implant fabrication could be achieved with high success rate by using AM technology with tailorable porosity. After World War II, biomaterials gained noteworthy attention due to desirable characteristics which can replace dysfunctioning human organs. Emergence of AM technologies and its collaboration with biomaterials made has a significant breakthrough in healthcare industry. Typical AM technologies mandated for developing biomedical implants are considered as an effective approach due to its versatility. This chapter aims to comprehensively discuss about the construction of functional biocomposites using AM technologies for potential biomedical implants. There has been many investigations made on various functional composites based on polymers, ceramics, metals and functionally graded materials (FGMs) for different biomedical implants such as hard and soft tissues, orthopedic and dental applications. The mechanical and biological behaviour of AM processed implants which makes them suitable for AM technology are further discussed with salient applications.
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References
Yan Q et al (2018) A review of 3D printing technology for medical applications. Engineering 4(5):729–742. https://doi.org/10.1016/j.eng.2018.07.021
Joung YH (2013) Development of implantable medical devices: from an engineering perspective. Int Neurourol J 17(3):98–106. https://doi.org/10.5213/inj.2013.17.3.98
Zadpoor AA (2017) Design for additive bio-manufacturing: from patient-specific medical devices to rationally designed meta-biomaterials. Int J Mol Sci 18(8):1607. https://doi.org/10.3390/ijms18081607
Touri M, Kabirian F, Saadati M, Ramakrishna S, Mozafari M (2019) Additive manufacturing of biomaterials—the evolution of rapid prototyping. Adv Eng Mater 21(2):1800511. https://doi.org/10.1002/adem.201800511
Singh AV et al (2019) The adoption of three-dimensional additive manufacturing from biomedical material design to 3D organ printing. Appl Sci (Switzerland) 9(4):811. https://doi.org/10.3390/app9040811
Norman J, Madurawe RD, Moore CMV, Khan MA, Khairuzzaman A (2017) A new chapter in pharmaceutical manufacturing: 3D-printed drug products. Adv Drug Deliv Rev 108:39–50. https://doi.org/10.1016/j.addr.2016.03.001
Coelho G, Chaves TMF, Goes AF, Del Massa EC, Moraes O, Yoshida M (2018) Multimaterial 3D printing preoperative planning for frontoethmoidal meningoencephalocele surgery. Child’s Nerv Syst 34(4):749–756. https://doi.org/10.1007/s00381-017-3616-6
Rosenzweig DH, Carelli E, Steffen T, Jarzem P, Haglund L (2015) 3D-printed ABS and PLA scaffolds for cartilage and nucleus pulposustissue regeneration. Int J Mol Sci 16(7):15118–15135. https://doi.org/10.3390/ijms160715118
Arabnejad S, Johnston B, Tanzer M, Pasini D (2017) Fully porous 3D printed titanium femoral stem to reduce stress-shielding following total hip arthroplasty. J Orthop Res 35(8):1774–1783. https://doi.org/10.1002/jor.23445
Quan Z et al (2015) Additive manufacturing of multi-directional preforms for composites: opportunities and challenges. Mater Today 18(9):503–512. https://doi.org/10.1016/j.mattod.2015.05.001
Liu Y, Wang W, Zhang LC (2017) Additive manufacturing techniques and their biomedical applications. Family Med Community Health 5(4):286–298. https://doi.org/10.15212/FMCH.2017.0110
Velu R, Calais T, Jayakumar A, Raspall F (2020) A comprehensive review on bio-nanomaterials for medical implants and feasibility studies on fabrication of such implants by additive manufacturing technique. Materials 13(1):92. https://doi.org/10.3390/ma13010092
Han X et al (2019) Carbon fiber reinforced PEEK composites based on 3D-printing technology for orthopedic and dental applications. J Clin Med 8(2):240. https://doi.org/10.3390/jcm8020240
Ahangar P, Cooke ME, Weber MH, Rosenzweig DH (2019) Current biomedical applications of 3D printing and additive manufacturing. Appl Sci (Switzerland) 9(8):1713. https://doi.org/10.3390/app9081713
Wilkes J, Hagedorn YC, Meiners W, Wissenbach K (2013) Additive manufacturing of ZrO2-Al2O3 ceramic components by selective laser melting. Rapid Prototyping J 19(1):51–57. https://doi.org/10.1108/13552541311292736
Hegab HA (2016) Design for additive manufacturing of composite materials and potential alloys: a review. Manuf Rev 3:11. https://doi.org/10.1051/mfreview/2016010
Jindal S, Manzoor F, Haslam N, Mancuso E (2021) 3D printed composite materials for craniofacial implants: current concepts, challenges and future directions. Int J Adv Manuf Technol 112(3–4):635–653. https://doi.org/10.1007/s00170-020-06397-1
Migliaresi C, Nicolais L (1980) Composite materials for biomedical applications. Int J Artif Organs 3(2):114–118. https://doi.org/10.1177/039139888000300213
Bandyopadhyay A, Heer B (2018) Additive manufacturing of multi-material structures. Mater Sci Eng R Rep 129(March):1–16. https://doi.org/10.1016/j.mser.2018.04.001
Gobbi SJ (2019) Requirements for selection/development of a biomaterial. Biomed J Sci Tech Res 14(3):1–6. https://doi.org/10.26717/bjstr.2019.14.002554
Varghese V (2011) Finite element-based design of hip joint prosthesis. https://doi.org/10.13140/RG.2.1.1903.8808
Song R, Murphy M, Li C, Ting K, Soo C, Zheng Z (2018) Current development of biodegradable polymeric materials for biomedical applications. Drug Des Dev Ther 12:3117–3145. https://doi.org/10.2147/DDDT.S165440
Szymczyk-Ziółkowska P, Łabowska MB, Detyna J, Michalak I, Gruber P (2020) A review of fabrication polymer scaffolds for biomedical applications using additive manufacturing techniques. Biocyber Biomed Eng 40(2):624–638. https://doi.org/10.1016/j.bbe.2020.01.015
Yuan S, Shen F, Chua CK, Zhou K (2019) Polymeric composites for powder-based additive manufacturing: materials and applications. Prog Polym Sci 91:141–168. https://doi.org/10.1016/j.progpolymsci.2018.11.001
Whenish R, Antony M, Balaji T, Selvam A (2021) Design and performance of additively manufactured lightweight bionic hand design and performance of additively manufactured lightweight bionic hand. In: AIP Conference Proceedings, vol 020028
Regassa Y, Lemu HG, Sirabizuh B (2019) Trends of using polymer composite materials in additive manufacturing. In: IOP conference series: materials science and engineering, vol 659, no 1. https://doi.org/10.1088/1757-899X/659/1/012021
Dziadek M, Stodolak-zych E, Cholewa-kowalska K (2016) SC. Mater Sci Eng C. https://doi.org/10.1016/j.msec.2016.10.014
Murr LE, Gaytan SM, Martinez E, Medina F, Wicker RB (2012) Next generation orthopaedic implants by additive manufacturing using electron beam melting. Int J Biomater 2012 https://doi.org/10.1155/2012/245727
Saad M, Akhtar S (2018) Science direct composite polymer in orthopedic implants: a review. Mater Today: Proc 5(9):20224–20231. https://doi.org/10.1016/j.matpr.2018.06.393
Ahlhelm M et al (2015) Innovative and novel manufacturing methods of ceramics and metal-ceramic composites for biomedical applications. J Eur Ceram Soc. https://doi.org/10.1016/j.jeurceramsoc.2015.12.020
Dormal T, Boilet L, Ceramic B, Ceramic B, Cambier F, Society EC (2013) Additive manufacturing of biocompatible ceramics. 2016:2018–2022. https://doi.org/10.14743/apem2013.2.157
Hajiali F, Tajbakhsh S, Shojaei A (2017) Fabrication and properties of polycaprolactone composites containing calcium phosphate-based ceramics and bioactive glasses in bone tissue engineering: a review. Polym Rev 1–44. https://doi.org/10.1080/15583724.2017.1332640
Yang Y et al (2020) Laser additive manufacturing of Mg-based composite with improved degradation behaviour. Virtual Phys Prototyping 1–16. https://doi.org/10.1080/17452759.2020.1748381
Singh S, Ramakrishna S, Singh R (2017) Material issues in additive manufacturing: a review. J Manuf Process 25:185–200. https://doi.org/10.1016/j.jmapro.2016.11.006
Attar H, Soro N, Kent D, Dargusch MS (2020) Additive manufacturing of low-cost porous titanium-based composites for biomedical applications: advantages, challenges and opinion for future development. J Alloys Compd 827:154263. https://doi.org/10.1016/j.jallcom.2020.154263
Hao Y, Li S, Yang R (2016) Biomedical titanium alloys and their additive manufacturing. Rare Met. https://doi.org/10.1007/s12598-016-0793-5
Mahmoud D, Elbestawi MA (2017) Lattice structures and functionally graded materials applications in additive manufacturing of orthopedic implants: a review, 1–19. https://doi.org/10.3390/jmmp1020013
Ngo TD, Kashani A, Imbalzano G, Nguyen KTQ, Hui D (2018) Additive manufacturing (3D printing): a review of materials, methods, applications and challenges. Compos B. https://doi.org/10.1016/j.compositesb.2018.02.012
Srinivasan R, Ruban W, Deepanraj A, Bhuvanesh R, Bhuvanesh T (2020) Effect on infill density on mechanical properties of PETG part fabricated by fused deposition modelling. Mater Today: Proc. https://doi.org/10.1016/j.matpr.2020.03.797
Selvam A, Mayilswamy S, Whenish R, Velu R, Subramanian B (2020) Preparation and evaluation of the tensile characteristics of carbon fiber rod reinforced 3D printed thermoplastic composites. J Compos Sci 5(1):8. https://doi.org/10.3390/jcs5010008
Haleem A, Javaid M (2019) Additive manufacturing. Clin Epidemiol Glob Health. https://doi.org/10.1016/j.cegh.2019.08.002
Ruban W, Vijayakumar V, Dhanabal P, Pridhar T (2014) Effective process parameters in selective laser sintering. Int J Rapid Manuf 4(2/3/4):148. https://doi.org/10.1504/ijrapidm.2014.066036
Mota C, Puppi D, Chiellini F, Chiellini E (2012) Additive manufacturing techniques for the production of tissue engineering constructs. https://doi.org/10.1002/term
Srinivasan R, Pridhar T, Ramprasath LS, Charan NS, Ruban W (2020) Prediction of tensile strength in FDM printed ABS parts using response surface methodology (RSM). Mater Today: Proc. https://doi.org/10.1016/j.matpr.2020.03.788
Selvam A, Mayilswamy S, Whenish R (2020) Strength improvement of additive manufacturing components by reinforcing carbon fiber and by employing bioinspired interlock sutures. J Vinyl Add Tech. https://doi.org/10.1002/vnl.21766
Ibrahim MZ, Sarhan AAD, Yusuf F, Hamdi M (2017) Biomedical materials and techniques to improve the tribological, mechanical and biomedical properties of orthopedic implants—a review article. J Alloy Compd. https://doi.org/10.1016/j.jallcom.2017.04.231
Journal B, Pita VJRR, Melo PA, Nele M, Pinto JC (2011) Production of bone cement composites: effect of fillers, co-monomer and particles properties. Brazilian J Chem Eng 28(02):229–241
Velu R, Kamarajan BP, Ananthasubramanian M, Ngo T, Singamneni S (2018) Post-process composition and biological responses of laser sintered PMMA and β-TCP composites. J Mater Res 33(14):1987–1998. https://doi.org/10.1557/jmr.2018.76
Velu R, Singamneni S (2014) Selective laser sintering of polymer biocomposites based on polymethyl methacrylate. J Mater Res 29(17):1883–1892. https://doi.org/10.1557/jmr.2014.211
Velu R, Singamneni S (2015) Evaluation of the influences of process parameters while selective laser sintering PMMA powders. Proc Inst Mech Eng C J Mech Eng Sci 229(4):603–613. https://doi.org/10.1177/0954406214538012
Pinto C (2006) Modeling methyl methacrylate (MMA) polymerization for bone cement production. In: Macromolecular Symposia, pp 13–23. https://doi.org/10.1002/masy.200651102
Cuadrado A, Yánez A, Martel O, Deviaene S, Monopoli D (2017) NU SC. Mater Des. https://doi.org/10.1016/j.matdes.2017.09.045
Murr LE (2019) Metallurgy principles applied to powder bed fusion 3D printing/additive manufacturing of personalized and optimized metal and alloy biomedical implants: an overview. Integr Med Res 9(1):1087–1103. https://doi.org/10.1016/j.jmrt.2019.12.015
Zhang X, Fang G, Leeflang S, Zadpoor AA, Zhou J (2019) Acta biomaterialia topological design, permeability and mechanical behavior of additively manufactured functionally graded porous metallic biomaterials. Acta Biomater 84:437–452. https://doi.org/10.1016/j.actbio.2018.12.013
Ponader S, et al (2009) In vivo performance of selective electron beam-melted Ti-6Al-4V structures. https://doi.org/10.1002/jbm.a.32337
Nune KC, Misra RDK, Gaytan SM, Murr LE (2014) Interplay between cellular activity and three-dimensional scaffold-cell constructs with different foam structure processed by electron beam melting. J Biomed Mater Res A 1677–1692. https://doi.org/10.1002/jbm.a.35307
Shi J, Yang J, Li Z, Zhu L, Li L, Wang X (2017) SC. J Alloys Compd 728:1043–1048. https://doi.org/10.1016/j.jallcom.2017.08.190
Wu S, Li Y, Zhang Y, Li X, Yuan C, Hao Y (2013) Porous titanium-6 aluminum-4 vanadium cage has better osseointegration and less micromotion than a poly-ether-ether-ketone cage in sheep vertebral fusion. Artif Organs 37(12):E191–E201. https://doi.org/10.1111/aor.12153
Li X et al (2012) Evaluation of biological properties of electron beam melted Ti6Al4V implant with biomimetic coating in vitro and in vivo. Plos one 7(12):1–12. https://doi.org/10.1371/journal.pone.0052049
Bandyopadhyay A, Espana F, Balla VK, Bose S, Davies NM (2011) NIH public access 6(4):1640–1648. https://doi.org/10.1016/j.actbio.2009.11.011.Influence
Wieding J, Jonitz A, Bader R (2012) The effect of structural design on mechanical properties and cellular response of additive manufactured titanium scaffolds. Materials 5(8):1336–1347. https://doi.org/10.3390/ma5081336
Thomsen P, Malmstro J, Emanuelsson L, Rene M, Snis A (2008) Electron beam-melted, free-form-fabricated titanium alloy implants: material surface characterization and early bone response in rabbits. https://doi.org/10.1002/jbm.b.31250
Gajendiran AM, Choi J, Kim S, Kim K, Shin H, Koo H (2017) Conductive applications biomaterials for tissue engineering. Korean Soc Ind Eng Chem. https://doi.org/10.1016/j.jiec.2017.02.031
Zadpoor AA, Malda J (2017) Additive manufacturing of biomaterials, tissues, and organs. Ann Biomed Eng 45(1):1–11. https://doi.org/10.1007/s10439-016-1719-y
Barba D, Alabort E, Reed RC (2019) Acta biomaterialia synthetic bone: design by additive manufacturing. Acta Biomater 97:637–656. https://doi.org/10.1016/j.actbio.2019.07.049
Murr LE (2017) Additive manufacturing of biomedical devices: an overview. Mater Technol 7857(November):1–14. https://doi.org/10.1080/10667857.2017.1389052
Wang X (2019) Bioartificial organ manufacturing technologies. Cell Transplant 28(77):5–17. https://doi.org/10.1177/0963689718809918
Singh S, Ramakrishna S (2017) Biomedical applications of additive manufacturing: present and future. Curr Opin Biomed Eng. https://doi.org/10.1016/j.cobme.2017.05.006
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Whenish, R., Velu, R., Anand Kumar, S., Ramprasath, L.S. (2022). Additive Manufacturing Technologies for Biomedical Implants Using Functional Biocomposites. In: Praveen Kumar, A., Sadasivuni, K.K., AlMangour, B., Abdul bin Majid, M.S. (eds) High-Performance Composite Structures. Composites Science and Technology . Springer, Singapore. https://doi.org/10.1007/978-981-16-7377-1_2
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