Abstract
Self-assembled hydrogels are a three-dimensional network of polymeric materials that are self-assembled either by physical or chemical crosslinking. Excellent biocompatibility, biodegradability, and sensitivity towards physiological stimulus make these materials as the best candidate for tissue culture, drug delivery, and development of sensors that can be. implanted on the human body. Whereas, versatile bonding that exists between the polymeric chain and water molecules and its ability to chelate metal ions extends its applications to photovoltaics and optics. This chapter focusses on the classification of self-assembled hydrogels based on their source and the nature of crosslinking force. The hydrogels formed by the self-assembly of biomolecules and the various factors governing their self-assembly like coiled-coil motifs, beta sheets, and beta-hairpin were discussed in the part, which was followed by a discussion synthetic hydrogels and their three different categories based on their nature of crosslinking force. Self-assembled hybrid hydrogels that are developed by the two distinct types of molecules are also evaluated.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Ahmed EM (2015) Hydrogel: preparation, characterization, and applications: a review. J Adv Res 6:105–121
Chen X et al (2018) Supramolecular hydrogels cross-linked by preassembled host–guest PEG cross-linkers resist excessive, ultrafast, and non-resting cyclic compression. NPG Asia Mater 10:788–799
Kopeček J, Yang J (2009) Peptide-directed self-assembly of hydrogels. Acta Biomater 5:805–816
Kopeček J (2007) Hydrogel biomaterials: a smart future? Biomaterials 28:5185–5192
Xu C, Kopeček J (2007) Self-assembling hydrogels. Polym Bull 58:53–63
Kaneko T, Yamaoka K, Gong JP, Osada Y (2000) Liquid crystalline hydrogels. 2. Effects of water on the structural ordering. Macromolecules 33:4422–4426
Wu ZL, Gong JP (2011) Hydrogels with self-assembling ordered structures and their functions. NPG Asia Mater 3:57–64
Lin BF et al (2012) pH-responsive branched peptide amphiphile hydrogel designed for applications in regenerative medicine with potential as injectable tissue scaffolds. J Mater Chem 22:19447
Kyle S, Aggeli A, Ingham E, McPherson MJ (2009) Production of self-assembling biomaterials for tissue engineering. Trends Biotechnol 27:423–433
El Yaagoubi M, Tewari KM, Lau KHA (2018) Peptoid self-assembly and opportunities for creating protein-mimetic biomaterials and biointerfaces. In: Self-assembling biomaterials. Elsevier. https://doi.org/10.1016/b978-0-08-102015-9.00006-x
Lao UL, Sun M, Matsumoto M, Mulchandani A, Chen W (2007) Genetic engineering of self-assembled protein hydrogel based on elastin-like sequences with metal binding functionality. Biomacromolecules 8:3736–3739
Xu C, Breedveld V, Kopeček J (2005) Reversible hydrogels from self-assembling genetically engineered protein block copolymers. Biomacromolecules 6:1739–1749
Riaz N, Wolden SL, Gelblum DY, Eric JA (2016) Rate insensitive linear viscoelastic model for soft tissues. Biomater 118:6072–6078. https://doi.org/10.1002/cncr.27633
Kopeček J, Yang J (2012) Smart self-assembled hybrid hydrogel biomaterials. Angew Chem Int Ed 51:7396–7417
Zhu F et al (2018a) Tough and conductive hybrid hydrogels enabling facile patterning. ACS Appl Mater Interfaces 10:13685–13692
Zhu S et al (2018b) Self-assembly of collagen-based biomaterials: preparation, characterizations and biomedical applications. J Mater Chem B6:2650–2676
Rosenblatt J, Devereux B, Wallace DG (1994) Injectable collagen as a pH-sensitive hydrogel. Biomaterials 15:985–995
Yonath J, Oplatka A (1968) Mechanochemical melting of collagen fibers. I. Mechanical contractions. Biopolymers 6:1129–1145
Oplatka A, Yonath J (1968) Mechanochemical melting of collagen fibers. II. Diffusion-controlled contractions. Biopolymers 6:1147–1158
Censi R, Di Martino P, Vermonden T, Hennink WE (2012) Hydrogels for protein delivery in tissue engineering. J Control Release 161:680–692
Mason JM, Arndt KM (2004) Coiled coil domains: stability, specificity, and biological implications. ChemBioChem 5:170–176
Truebestein L, Leonard TA (2016) Coiled-coils: the long and short of it. BioEssays 38:903–916
Nowick JS (2008) Exploring beta-sheet structure and interactions with chemical model systems. Acc Chem Res 41:1319–1330
Aggeli A et al (2001) Hierarchical self-assembly of chiral rod-like molecules as a model for peptide beta-sheet tapes, ribbons, fibrils, and fibers. Proc Natl Acad Sci USA 98:11857–11862
Clarke DE, Pashuck ET, Bertazzo S, Weaver JVM, Stevens MM (2017) Self-healing, self-assembled β-sheet peptide-poly(γ-glutamic acid) hybrid hydrogels. J Am Chem Soc 139:7250–7255
Clarke DE, Parmenter CDJ, Scherman OA (2018) Tunable pentapeptide self-assembled β-sheet hydrogels. Angew Chem Int Ed 57:7709–7713
Milner-White EJ, Poet R (1986) Four classes of beta-hairpins in proteins. Biochem J 240:289–292
Larini L, Shea J-E (2012) Role of β-hairpin formation in aggregation: the self-assembly of the amyloid-β(25–35) peptide. Biophys J 103:576–586
Rajagopal K, Lamm MS, Haines-Butterick LA, Pochan DJ, Schneider JP (2009) Tuning the pH responsiveness of β-hairpin peptide folding, self-assembly, and hydrogel material formation. Biomacromolecules 10:2619–2625
Miller Y, Ma B, Nussinov R (2015) Polymorphism in self-assembly of peptide-based β-hairpin contributes to network morphology and hydrogel mechanical rigidity. J Phys Chem B 119:482–490
Dong R, Pang Y, Su Y, Zhu X (2015) Supramolecular hydrogels: synthesis, properties and their biomedical applications. Biomater Sci 3:937–954
Du X, Zhou J, Shi J, Xu B (2015) Supramolecular hydrogelators and hydrogels: from soft matter to molecular biomaterials. Chem Rev 115:13165–13307
Zhou Y, Fan X, Zhang W, Xue D, Kong J (2014) Stimuli-induced gel-sol transition of supramolecular hydrogels based on β-cyclodextrin polymer/ferrocene-containing triblock copolymer inclusion complexes. J Polym Res 21:359
Hou S, Ma PX (2015) Stimuli-responsive supramolecular hydrogels with high extensibility and fast self-healing via precoordinated mussel-inspired chemistry. Chem Mater 27:7627–7635
Kousar A, Feng C (2019) Controlled mechanical properties and supramolecular chirality of hydrogels via pH change. Methods X6:417–423
Li J (2010) Self-assembled supramolecular hydrogels based on polymer-cyclodextrin inclusion complexes for drug delivery. NPG Asia Mater 2:112–118
Eskandari S, Guerin T, Toth I, Stephenson RJ (2017) Recent advances in self-assembled peptides: implications for targeted drug delivery and vaccine engineering. Adv Drug Delivery Rev 110–111:169–187
Naota T, Koori H (2005) Molecules that assemble by sound: an application to the instant gelation of stable organic fluids. https://doi.org/10.1021/JA050809H
Isozaki K, Takaya H, Naota T (2007) Ultrasound-induced gelation of organic fluids with metalated peptides. Angew Chem Int Ed 46:2855–2857
Grigoriou S et al (2012) Dipeptide hydrogel formation triggered by boronic acid–sugar recognition. Soft Matter 8:6788
Marchesan S et al (2012) Unzipping the role of chirality in nanoscale self-assembly of tripeptide hydrogels. Nanoscale 4:6752
Zhao F, Gao Y, Shi J, Browdy HM, Xu B (2011) Novel anisotropic supramolecular hydrogel with high stability over a wide pH range†. Langmuir 27:1510–1512
Suzuki M, Yumoto M, Shirai H, Hanabusa K (2005) l-Lysine-based supramolecular hydrogels containing various inorganic ions. Org Biomol Chem 3:3073
Yang Z, Liang G, Xu B (2008) Enzymatic hydrogelation of small molecules. Acc Chem Res 41:315–326
Yang ZM, Xu KM, Guo ZF, Guo ZH, Xu B (2007) Intracellular enzymatic formation of nanofibers results in hydrogelation and regulated cell death. Adv Mater 19:3152–3156
Richardson PJ, Brown SJ, Bailyes EM, Luzio JP (1987) Ectoenzymes control adenosine modulation of immunoisolated cholinergic synapses. Nature 327:232–234
Pospisil P, Iyer LK, Adelstein SJ, Kassis AI (2006) A combined approach to data mining of textual and structured data to identify cancer-related targets. BMC Bioinform 7:354
Nakashima T, Kimizuka N (2002) Light-harvesting supramolecular hydrogels assembled from short-legged cationic L-glutamate derivatives and anionic fluorophores. Adv Mater 14:1113
Wang H et al (2010) Enzyme-triggered self-assembly of a small molecule: a supramolecular hydrogel with leaf-like structures and an ultra-low minimum gelation concentration. Nanotechnology 21:225606
Milkovich R (1981) Synthesis of controlled polymer structures, pp 41–57. https://doi.org/10.1021/bk-1981-0166.ch003
Gao GH, Li Y, Lee DS (2012) Block copolymer hydrogels. In: Encyclopedia of polymer science and technology. https://doi.org/10.1002/0471440264.pst577
Jeong B, Bae YH, Lee DS, Kim SW (1997) Biodegradable block copolymers as injectable drug-delivery systems. Nature 388:860–862
Fu H et al (2011) Preparation and tunable temperature sensitivity of biodegradable polyurethane nanoassemblies from diisocyanate and poly(ethylene glycol). Soft Matter 7:3546
Li X et al (2009) Self-assembled polymeric micellar nanoparticles as nanocarriers for poorly soluble anticancer drug ethaselen. Nanoscale Res Lett 4:1502–1511
Hwang MJ et al (2010) Multiple sol-gel transitions of PEG-PCL-PEG triblock copolymer aqueous solution. Macromol Rapid Commun 31:2064–2069
Brand HR, Martinoty P, Pleiner H (2011) Physical properties of magnetic gels
Popov N et al (2017) Thermotropic liquid crystal-assisted chemical and biological sensors. Materials. https://doi.org/10.3390/ma11010020
Kaneko T, Yamaoka K, Gong JP, Osada Y (2000) Liquid-crystalline hydrogels. 1. Enhanced effects of incorporation of acrylic acid units on the liquid-crystalline ordering. https://doi.org/10.1021/MA991528V
Yamaoka K, Kaneko T, Gong JP, Osada Y (2001) Liquid crystalline gels. 3. Role of hydrogen bonding in the formation and stabilization of mesophase structures. Macromolecules 34:1470–1476
van der Asdonk P, Kouwer PHJ (2017) Liquid crystal templating as an approach to spatially and temporally organise soft matter. Chem Soc Rev 46:5935–5949
Haque MA et al (2018) Tough and variable-band-gap photonic hydrogel displaying programmable angle-dependent colors. ACS Omega 3:55–62
Wu ZL, Kurokawa T, Gong JP (2012) Hydrogels with a macroscopic-scale liquid crystal structure by self-assembly of a semi-rigid polyion complex. Polym J 44:503–511
Wu ZL et al (2011) Anisotropic hydrogel from complexation-driven reorientation of semirigid polyanion at Ca2+ diffusion flux front. Macromolecules 44:3535–3541
Sun T, Wu Z, Gong J (2012) Self-assembled structures of a semi-rigid polyanion in aqueous solutions and hydrogels. Sci China Chem 55:735–742
Shigekura Y et al (2005) Anisotropic polyion-complex gels from template polymerization. Adv Mater 17:2695–2699
Wu ZL, Kurokawa T, Liang S, Gong JP (2010) Dual network formation in polyelectrolyte hydrogel via viscoelastic phase separation: role of ionic strength and polymerization kinetics. Macromolecules 43:8202–8208
Annabi N et al (2016) Highly elastic and conductive human-based protein hybrid hydrogels. Adv Mater 28:40–49
Pechar M, Kopečková P, Joss L, Kopeček J (2002) Associative diblock copolymers of poly(ethylene glycol) and coiled-coil peptides. Macromol Biosci 2:199
Hamley IW (2014) PEG–peptide conjugates. Biomacromolecules 15:1543–1559
Yang J, Xu C, Kopečková P, Kopeček J (2006) Hybrid hydrogels self-assembled from HPMA copolymers containing peptide grafts. Macromol Biosci 6:201–209
Wang C, Stewart RJ, KopeČek J (1999) Hybrid hydrogels assembled from synthetic polymers and coiled-coil protein domains. Nature 397:417–420
Xia Y et al (2017) Printable fluorescent hydrogels based on self-assembling peptides. Sci Rep 7:1–10
Yuk H, Lu B, Zhao X (2019) Hydrogel bioelectronics. Chem Soc Rev 48:1642–1667
Cai G et al (2017) Extremely stretchable strain sensors based on conductive self-healing dynamic cross-links hydrogels for human-motion detection. Adv Sci 4:1600190
Hirst AR, Escuder B, Miravet JF, Smith DK (2008) High-tech applications of self-assembling supramolecular nanostructured gel-phase materials: from regenerative medicine to electronic devices. Angew Chem Int Ed 47:8002–8018
Ellis-Behnke RG et al (2006) Nano neuro knitting: peptide nanofiber scaffold for brain repair and axon regeneration with functional return of vision. Proc Natl Acad Sci 103:5054–5059
Kishimura A, Yamashita T, Aida T (2004) Phosphorescent organogels via “metallophilic” interactions for reversible RGB−color switching. https://doi.org/10.1021/JA0441007
Kishimura A, Yamashita T, Yamaguchi K, Aida T (2005) Rewritable phosphorescent paper by the control of competing kinetic and thermodynamic self-assembling events. Nat Mater 4:546–549
Miravet JF, Escuder B (2005) Pyridine-functionalised ambidextrous gelators: towards catalytic gels. Chem Commun 5796. https://doi.org/10.1039/b510874h
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2021 Springer Nature Singapore Pte Ltd.
About this chapter
Cite this chapter
Anil, A., Jose, J. (2021). Self-assembled Hydrogels: An Overview. In: Jose, J., Thomas, S., Thakur, V.K. (eds) Nano Hydrogels. Gels Horizons: From Science to Smart Materials. Springer, Singapore. https://doi.org/10.1007/978-981-15-7138-1_14
Download citation
DOI: https://doi.org/10.1007/978-981-15-7138-1_14
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-15-7137-4
Online ISBN: 978-981-15-7138-1
eBook Packages: Chemistry and Materials ScienceChemistry and Material Science (R0)