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Methylation of Inflammatory Cells in Lung Diseases

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Single-cell Sequencing and Methylation

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1255))

Abstract

This chapter overviews roles of DNA methylation in inflammatory cell biology with the focuses on lymphocytes and macrophages/monocytes in lung diseases, although the molecular mechanisms by which target genes are methylated and regulated in lung diseases remain unclear. Most of epigenetic studies on DNA methylation of target genes in lung diseases mainly demonstrated the correlation of DNA methylation of target genes with the levels of other corresponding factors, with the specificity of clinical phenomes, and with the severity of lung diseases. There is an urgent need to identify and validate the specificity and regulatory mechanisms of inflammatory cell epigenetics in depth. The epigenetic heterogeneity among different subsets of T cells and among promoters or non-promoters of target genes should be furthermore clarified in acute or chronic lung diseases and cancers. The hyper/hypo-methylation and modifications of chromosol and extrachromosomal DNA may result in alternations in proteins within inflammatory cells, which can be identified as disease-specific biomarkers and therapeutic targets.

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Author information

Author notes

  1. Yifei Liu and Hongzhi Gao contributed equally to this work.

Authors and Affiliations

  1. Clinical Center for Molecular Diagnosis and Therapy, Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian Province, China

    Yifei Liu & Hongzhi Gao

  2. Zhongshan Hospital, Fudan University, Shanghai, Shanghai, China

    Xiangdong Wang

  3. 2nd Affiliated Hospital, Fujian Medical University, Quanzhou, Fujian, China

    Yiming Zeng

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  1. Yifei Liu
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  2. Hongzhi Gao
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  3. Xiangdong Wang
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  4. Yiming Zeng
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Editor information

Editors and Affiliations

  1. Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, Shanghai, China

    Buwei Yu

  2. Department of Anesthesiology and Perioperative Medicine, Center of Clinical Single-Cell Biomedicine, Henan Provincial People’s Hospital, Zhengzhou, University People’s Hospital, Henan University People’s Hospital, Zhengzhou, P.R., China

    Jiaqiang Zhang

  3. 2nd Affiliated Hospital, Fujian Medical University, Quanzhou, Fujian, China

    Yiming Zeng

  4. Centre for Single Cell Biomedicine, Henan Provincial People’s Hospital, Zhengzhou, Henan, China

    Li Li

  5. Zhongshan Hospital, Fudan University, Shanghai, Shanghai, China

    Xiangdong Wang

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Liu, Y., Gao, H., Wang, X., Zeng, Y. (2020). Methylation of Inflammatory Cells in Lung Diseases. In: Yu, B., Zhang, J., Zeng, Y., Li, L., Wang, X. (eds) Single-cell Sequencing and Methylation. Advances in Experimental Medicine and Biology, vol 1255. Springer, Singapore. https://doi.org/10.1007/978-981-15-4494-1_5

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