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Single Cell RNA Sequencing in Human Disease: Renal, Pancreatic, and Viral Diseases

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Single-cell Sequencing and Methylation

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1255))

Abstract

In this chapter, we discussed some of the specific uses of scRNA-seq in exploring viral infections and diseases of the kidney and pancreas. This review, however, is by no means exhaustive, and indeed this technology has advanced the study of pulmonary and cardiac diseases, transplant immunology, cancer, and many others as well. Nevertheless, the above reviewed studies do illustrate the utility and resolution of scRNA-seq in understanding exact cellular compositions, discovering heterogeneity within cellular expression patterns, and uncovering clues that may eventually lead to the development of more targeted and personalized therapies. Additionally, the increasing availability of whole tissue cellular atlases in both health and disease as a result of scRNA-seq studies provides an important resource to better understand complicated molecular signaling patterns and events that are similar and different between human diseases.

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Author information

Authors and Affiliations

  1. Sue Golding Graduate Division of the Albert Einstein College of Medicine, Bronx, NY, USA

    Sayra Garcia & Evan Der

  2. Division of Rheumatology, Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA

    Chaim Putterman

  3. Azrieli Faculty of Medicine, Bar–Ilan University, Safed, Israel

    Chaim Putterman

  4. Research Institute, Galilee Medical Center, Nahariya, Israel

    Chaim Putterman

Authors
  1. Sayra Garcia
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  2. Evan Der
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  3. Chaim Putterman
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Corresponding author

Correspondence to Chaim Putterman .

Editor information

Editors and Affiliations

  1. Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, Shanghai, China

    Buwei Yu

  2. Department of Anesthesiology and Perioperative Medicine, Center of Clinical Single-Cell Biomedicine, Henan Provincial People’s Hospital, Zhengzhou, University People’s Hospital, Henan University People’s Hospital, Zhengzhou, P.R., China

    Jiaqiang Zhang

  3. 2nd Affiliated Hospital, Fujian Medical University, Quanzhou, Fujian, China

    Yiming Zeng

  4. Centre for Single Cell Biomedicine, Henan Provincial People’s Hospital, Zhengzhou, Henan, China

    Li Li

  5. Zhongshan Hospital, Fudan University, Shanghai, Shanghai, China

    Xiangdong Wang

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Garcia, S., Der, E., Putterman, C. (2020). Single Cell RNA Sequencing in Human Disease: Renal, Pancreatic, and Viral Diseases. In: Yu, B., Zhang, J., Zeng, Y., Li, L., Wang, X. (eds) Single-cell Sequencing and Methylation. Advances in Experimental Medicine and Biology, vol 1255. Springer, Singapore. https://doi.org/10.1007/978-981-15-4494-1_16

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