Skip to main content

Autophagy and Hemorrhagic Stroke

  • Chapter
  • First Online:
Autophagy: Biology and Diseases

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1207))

Abstract

Hemorrhagic stroke includes cerebral hemorrhage and subarachnoid hemorrhage. An increasing number of studies have found that autophagy also occurs in brain tissues after cerebral hemorrhage and subarachnoid hemorrhage. The potential role of selective autophagy in the clinical treatment of hemorrhagic stroke has been recognized, but a consensus on the exact effect and function of autophagy has not been reached, and the mechanism needs to be further studied. In this chapter, the mechanism of brain injury after cerebral hemorrhage and subarachnoid hemorrhage is briefly introduced, and changes in the autophagy pathway and the role of autophagy in the process of brain injury are discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 189.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 249.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 249.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

References

  • Chang P, Dong W, Zhang M et al (2014) Anti-necroptosis chemical necrostatin-1 can also suppress apoptotic and autophagic pathway to exert neuroprotective effect in mice intracerebral hemorrhage model. J Mol Neurosci 52:242–249

    Article  CAS  Google Scholar 

  • Chen RR (2012) Effect of naoxetong on autophagy in peripheral tissues of hematoma lesions after cerebral hemorrhage in rats. Master’s thesis

    Google Scholar 

  • Chen TY, Tsai KL, Lee TY et al (2010) Sex-specific role of thioredoxin in neuroprotection against iron-induced brain injury conferred by estradiol. Stroke 41:160–165

    Article  CAS  Google Scholar 

  • Chen CW, Chen TY, Tsai KL et al (2012) Inhibition of autophagy as a therapeutic strategy of iron-induced brain injury after hemorrhage. Autophagy 8:1510–1520

    Article  CAS  Google Scholar 

  • Chen J, Wang L, Wu C et al (2014) Melatonin-enhanced autophagy protects against neural apoptosis via a mitochondrial pathway in early brain injury following a subarachnoid hemorrhage. J Pineal Res 56:12–19

    Article  CAS  Google Scholar 

  • Chen S, Wu H, Tang J et al (2015) Neurovascular events after subarachnoid hemorrhage: focusing on subcellular organelles. Acta Neurochir Suppl 120:39–46

    PubMed  PubMed Central  Google Scholar 

  • Chen N, Dai L, Jiang Y et al (2016) Endoplasmic reticulum stress intolerance in EIF2B3 mutant oligodendrocytes is modulated by depressed autophagy. Brain Develop 38:507–515

    Article  Google Scholar 

  • Fang Y, Chen S, Reis C et al (2018) The role of autophagy in subarachnoid hemorrhage: an update. Curr Neuropharmacol 16(9):1255–1266

    Article  CAS  Google Scholar 

  • Gong Y, Hua Y, Keep RF et al (2004) Intracerebral hemorrhage: effects of aging on brain edema and neurological deficits. Stroke 35:2571–2575

    Article  Google Scholar 

  • Gong Y, He Y, Gu Y et al (2011) Effects of aging on autophagy after experimental intracerebral hemorrhage. Acta Neurochir Suppl 111:113–117

    Article  Google Scholar 

  • He Y, Hua Y, Song S et al (2008a) Induction of autophagy in rat hippocampus and cultured neurons by iron. Acta Neurochir Suppl 105:29–32

    Article  CAS  Google Scholar 

  • He YD, Wan S, Hua Y et al (2008b) Autophagy after experimental intracerebral Hemorrhage. J Cereb Blood Flow Metab 28:897–905

    Article  CAS  Google Scholar 

  • Hua Y, Keep RF, Hoff JT et al (2007) Brain injury after intracerebral hemorrhage: the role of thrombin and iron. Stroke 38(Suppl):759–762

    Article  CAS  Google Scholar 

  • Ji C, Chen G (2016) Signaling pathway in early brain injury after subarachnoid hemorrhage: news update. Acta neurochirurgica. Supplement 121:123–126

    Article  Google Scholar 

  • Jing ZH (2012) Role and mechanism of autophagy in early brain injury after subarachnoid hemorrhage in rats. Doctoral dissertation, III

    Google Scholar 

  • Jing CH, Wang L, Liu PP et al (2012) Autophagy activation is associated with neuroprotection against apoptosis via a mitochondrial pathway in a rat model of subarachnoid hemorrhage. Neuroscience 213:144–153

    Article  CAS  Google Scholar 

  • Keep RF, Hua Y, Xi GH (2012) Intracerebral haemorrhage: mechanisms of injury and therapeutic targets. Lancet Neurol 11:720–731

    Article  CAS  Google Scholar 

  • Lee JY, He YD, Sagher O et al (2009) Activated autophagy pathway in experimental subarachnoid hemorrhage. Brain Res 1287:126–135

    Article  CAS  Google Scholar 

  • Li J, Lu JF, Mi YJ et al (2014) Voltage-dependent anion channels (VDACs) promote mitophagy to protect neuron from death in an earlybrain injury following a subarachnoid hemorrhage in rats. Brain Res 1573:74–83

    Article  CAS  Google Scholar 

  • Li T, Sun KJ, Wang HD et al (2015) Tert-butylhydroquinone ameliorates early brain injury after experimental subarachnoid hemorrhage in mice by enhancing nrf2-independent autophagy. Neurochem Res 40:1829–1838

    Article  CAS  Google Scholar 

  • Li H, Wu J, Shen H et al (2017) Autophagy in hemorrhagic stroke: mechanisms and clinical implications. Prog Neurobiol. https://doi.org/10.1016/j.pneurobio.2017.04.002

    Article  PubMed  PubMed Central  Google Scholar 

  • Liu Y, Cai H, Wang Z et al (2013) Induction of autophagy by cystatin C: a potential mechanism for prevention of cerebral vasospasm after experimental subarachnoid hemorrhage. Eur J Med Res 18:21

    Google Scholar 

  • Liu RY, Wang JJ, Qiu X et al (2014a) Acute hyperglycemia together with hematoma of high-glucose blood exacerbates neurological injury in a rat model of intracerebral hemorrhage. Neurosci Bull 30:90–98

    Article  Google Scholar 

  • Liu Y, Li J, Wang Z et al (2014b) Attenuation of early brain injury and learning deficits following experimental subarachnoid hemorrhage secondary to Cystatin C: possible involvement of the autophagy pathway. Mol Neurobiol 49:1043–1054

    Article  CAS  Google Scholar 

  • Qureshi AI, Suri MF, Ostrow PT et al (2003) Apoptosis as a form of cell death in intracerebral hemorrhage. Neumsurgery 52:1041–1047

    Google Scholar 

  • Roof RL, Hall ED (2000) Gender differences in acute CNS trauma and stroke: neuroprotective effects of estrogen and progesterone. J Neurotrauma 17:367–388

    Article  CAS  Google Scholar 

  • Urday S, Kimberly WT, Beslow LA et al (2015) Targeting secondary injury in intracerebral haemorrhage-perihaematomal oedema. Nature Reviews Neurology 11:111–122

    Article  Google Scholar 

  • Wang Z, Shi XY, Yin J et al (2012) Role of autophagy in early brain injury after experimental subarachnoid hemorrhage. J Mol Neurosci 46:192–202

    Article  CAS  Google Scholar 

  • Wu J, Hua Y, Keep RF et al (2003) Iron and iron-handling proteins in the brain after intracerebral hemorrhage. Stroke 34:2964–2969

    Article  CAS  Google Scholar 

  • Wu J, Jia JP, Cui LY (2010) Neurology. People’s Health Publishing House. p 170

    Google Scholar 

  • Wu Y, Wang L, Hu K et al (2018) Mechanisms and therapeutic targets of depression after intracerebral hemorrhage. Front Psychiatry 9:682

    Article  Google Scholar 

  • Xi G, Keep RF, Hoff JT (2006) Mechanisms of brain injury after intracerebral haemorrhage. Lancet Neurol 5:53–63

    Article  Google Scholar 

  • Yan F, Li JR, Chen JY et al (2014) Endoplasmic reticulum stress is associated with neuroprotection against apoptosis via autophagy activation in a rat model of subarachnoid hemorrhage. Neurosci Lett 563:160–165

    Article  CAS  Google Scholar 

  • Yang Z, Zhang N, Liu Y et al (2014) TLR4-mediated autophagy contributes to microglial activation and inflammatory injury in mouse models of intracerebral haemorrhage. Neuropathol Appl Neurobiol 41:e95–106

    Article  Google Scholar 

  • Zhao H, Ji Z, Tang D et al (2013) Role of autophagy in early brain injury after subarachnoid hemorrhage in rats. Mol Biol Rep 40:819–827

    Article  CAS  Google Scholar 

  • Zia E, Engström G, Svensson PJ et al (2009) Three-year survival and stroke recurrence rates in patients with primary intracerebral hemorrhage. Stroke 40:3567–3573

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Chunfeng Liu .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2020 Science Press and Springer Nature Singapore Pte Ltd.

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Zhang, Y., Liu, C. (2020). Autophagy and Hemorrhagic Stroke. In: Le, W. (eds) Autophagy: Biology and Diseases. Advances in Experimental Medicine and Biology, vol 1207. Springer, Singapore. https://doi.org/10.1007/978-981-15-4272-5_8

Download citation

Publish with us

Policies and ethics