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Brain Iron Metabolism and Regulation

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Brain Iron Metabolism and CNS Diseases

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1173))

Abstract

With the development of research, more and more evidences suggested that mutations in the genes associated with brain iron metabolism induced diseases in the brain. Brain iron metabolism disorders might be one cause of neurodegenerative diseases. This review mainly summarizes the normal process of iron entry into the brain across the blood–brain barrier, and the distribution and transportation of iron among neurons and glial cells, as well as the underlying regulation mechanisms. To understand the mechanisms of iron metabolism in the brain will provide theoretical basis to prevent and cure brain diseases related to iron metabolism disorders.

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Acknowledgements

The work was supported by the National Natural Science Foundation of China (31520103908, 31970905), Hebei Provincial Natural Science Foundation (C2017205140), Hebei Provincial Education Department Foundation of China (ZD2015105), Hebei Provincial Fund for studying abroad and returning to China (C201862), and Hebei normal University Outstanding Youth Fund (L2018J05).

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  1. Laboratory of Molecular Iron Metabolism, Key Laboratory of Animal Physiology, Biochemistry and Molecular Biology of Hebei Province, College of Life Sciences, Hebei Normal University, 20, Nanerhuan Eastern Road, Shijiazhuang, Hebei Province, 050024, China

    Peng Yu & Yan-Zhong Chang

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Correspondence to Peng Yu or Yan-Zhong Chang .

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    Yan-Zhong Chang

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Yu, P., Chang, YZ. (2019). Brain Iron Metabolism and Regulation. In: Chang, YZ. (eds) Brain Iron Metabolism and CNS Diseases. Advances in Experimental Medicine and Biology, vol 1173. Springer, Singapore. https://doi.org/10.1007/978-981-13-9589-5_3

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