Abstract
Chitooligosaccharides and chitin oligosaccharides are collectively referred to as aminooligosaccharides. The monomer of chito/chitin oligosaccharides are N-acetyl-D-glucosamine and glucosamine, two of the few nitrogenous sugars in nature. Chito/chitin oligosaccharides are mainly produced by hydrolysis from natural aminopolysaccharides (chitosan and chitin), which are extracted from crab and shrimp shells resource. Chitin and chitosan are well known as natural polysaccharides with abundant biological activities. Similarly, chito/chitin oligosaccharides also have a number of commercial uses as their biological activities. This chapter summarizes the history and chemical-based topics like definition, origin, structure, molecular weight, classification of chitin, chitosan, chito/chitin oligosaccharides and their monomers (N-acetyl-D-glucosamine and glucosamine). Due to the broad research interests and market demands, the discovery and development of biological activities of chito/chitin oligosaccharides are summarized as argument.
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References
Allan CR, Hadwiger LA (1979) Fungicidal effect of chitosan on fungi of varying cell wall composition[J]. Exp Mycol 3(3):285–287
Chung YC, Su YP, Chen CC et al (2004) Relationship between antibacterial activity of chitosan and surface characteristics of cell wall.[J]. Acta Pharmacol Sin 25(7):932–936
Huang R, Mendis E, Rajapakse N et al (2006) Strong electronic charge as an important factor for anticancer activity of chitooligosaccharides (COS)[J]. Life Sci 78(20):0–2408
Je JY, Kim SK (2006) Chitosan derivatives killed Bacteria by disrupting the outer and inner membrane[J]. J Agric Food Chem 54(18):6629–6633
Lan W, Wang W, Yu Z et al (2016) Enhanced germination of barley (Hordeum vulgareL.) using chitooligosaccharide as an elicitor in seed priming to improve malt quality[J]. Biotechnol Lett 38(11):1935–1940
Li K, Xing R, Liu S et al (2012) Separation of chito-oligomers with several degrees of polymerization and study of their antioxidant activity[J]. Carbohydr Polym 88(3):896–903
Liaqat F, Eltem R (2017) Chitooligosaccharides and their biological activities: a comprehensive review[J]. Carbohydr Polym 7:5113. S0144861717314789
Liu XF, Guan YL, Yang DZ et al (2001) Antibacterial action of chitosan and carboxymethylated chitosan[J]. J Appl Polym Sci 79(7):12
Luo C, Liu W, Luo B et al (2016) Antibacterial activity and cytocompatibility of chitooligosaccharide-modified polyurethane membrane via polydopamine adhesive layer[J]. Carbohydr Polym. S0144861716310906
MengÃbar M, Mateos-Aparicio I, Miralles B et al (2013) Influence of the physico-chemical characteristics of chito-oligosaccharides (COS) on antioxidant activity[J]. Carbohydr Polym 97(2):776–782
Minagawa T, Okamura Y, Shigemasa Y et al (2007) Effects of molecular weight and deacetylation degree of chitin/chitosan on wound healing[J]. Carbohydr Polym 67(4):640–644
Okamoto Y, Yano R, Miyatake K et al (2003) Effects of chitin and chitosan on blood coagulation[J]. Carbohydr Polym 53(3):337–342
Park PJ, Je JY, Kim SK (2003) Angiotensin I Converting Enzyme (ACE) inhibitory activity of hetero-Chitooligosaccharides prepared from partially different Deacetylated Chitosans[J]. J Agric Food Chem 51(17):4930–4934
Ratanavaraporn J, Kanokpanont S, Tabata Y et al (2009) Growth and osteogenic differentiation of adipose-derived and bone marrow-derived stem cells on chitosan and chitooligosaccharide films[J]. Carbohydr Polym 78(4):873–878
Salah R, Michaud P, Mati F et al (2013) Anticancer activity of chemically prepared shrimp low molecular weight chitin evaluation with the human monocyte leukaemia cell line, THP-1[J]. Int J Biol Macromol 52(none):333–339
Sanchez A, Mengibar M, Fernandez et al (2018) Influence of preparation methods of Chitooligosaccharides on their physicochemical properties and their anti-inflammatory effects in mice and in RAW264.7 macrophages[J]. Mar Drugs 16:430
Yamada A, Shibuya N, Kodama O et al (1993) Induction of phytoalexin formation in suspension-cultured rice cells by N-Acetylchitooligosaccharides[J]. Biosci Biotech Bioch 57(3):405–409
Yang Y, Xing R, Liu S et al (2017) Immunostimulatory effects of Chitooligosaccharides on RAW 264.7 mouse macrophages via regulation of the MAPK and PI3 K/Akt signaling pathway[J]. Int J Biol Macromol 108
Zhang J, Zhang W, Mamadouba B et al (2012) A comparative study on hypo-lipidemic activities of high and low molecular weight chitosan in rats[J]. Int J Biol Macromol 51(4):504–508
Zong H, Li K, Liu S et al (2017) Improvement in cadmium tolerance of edible rape (Brassica rapa, L.) with exogenous application of chitooligosaccharide[J]. Chemosphere 181:92–100
Zou P, Li K, Liu S et al (2016) Effect of sulfated Chitooligosaccharides on wheat seedlings (Triticum aestivum L.) under salt stress[J]. J Agric Food Chem 64(14):2815–2821
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Qin, Z., Zhao, L. (2019). The History of Chito/Chitin Oligosaccharides and Its Monomer. In: Zhao, L. (eds) Oligosaccharides of Chitin and Chitosan. Springer, Singapore. https://doi.org/10.1007/978-981-13-9402-7_1
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DOI: https://doi.org/10.1007/978-981-13-9402-7_1
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Publisher Name: Springer, Singapore
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