Abstract
The C. elegans epidermis, a single epithelial layer surrounding the animal, is a potential model skin. The epidermal barrier is another important primary biological barrier for nematodes against the toxicity of environmental toxicants or stresses. We here mainly introduced and discussed the molecular basis of epidermal barrier against the toxicity of environmental toxicants or stresses. The association between epidermal barrier and activation of innate immune response was also discussed.
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References
Wang D-Y (2018) Nanotoxicology in Caenorhabditis elegans. Springer, Singapore
Wang D-Y (2018) Molecular toxicology in Caenorhabditis elegans. Springer, Singapore
Xiao G-S, Zhao L, Huang Q, Yang J-N, Du H-H, Guo D-Q, Xia M-X, Li G-M, Chen Z-X, Wang D-Y (2018) Toxicity evaluation of Wanzhou watershed of Yangtze Three Gorges Reservoir in the flood season in Caenorhabditis elegans. Sci Rep 8:6734
Yin J-C, Liu R, Jian Z-H, Yang D, Pu Y-P, Yin L-H, Wang D-Y (2018) Di (2-ethylhexyl) phthalate-induced reproductive toxicity involved in DNA damage-dependent oocyte apoptosis and oxidative stress in Caenorhabditis elegans. Ecotoxicol Environ Saf 163:298–306
Xiao G-S, Zhao L, Huang Q, Du H-H, Guo D-Q, Xia M-X, Li G-M, Chen Z-X, Wang D-Y (2018) Biosafety assessment of water samples from Wanzhou watershed of Yangtze Three Gorges Reservoir in the quiet season in Caenorhabditis elegans. Sci Rep 8:14102
Dong S-S, Qu M, Rui Q, Wang D-Y (2018) Combinational effect of titanium dioxide nanoparticles and nanopolystyrene particles at environmentally relevant concentrations on nematodes Caenorhabditis elegans. Ecotoxicol Environ Saf 161:444–450
Wang D-Y, Yu Y-L, Li Y-X, Wang Y, Wang D-Y (2014) Dopamine receptors antagonistically regulate behavioral choice between conflicting alternatives in C. elegans. PLoS One 9:e115985
Li Y-X, Wang Y, Hu Y-O, Zhong J-X, Wang D-Y (2011) Modulation of the assay system for the sensory integration of 2 sensory stimuli that inhibit each other in nematode Caenorhabditis elegans. Neurosci Bull 27:69–82
Ruan Q-L, Qiao Y, Zhao Y-L, Xu Y, Wang M, Duan J-A, Wang D-Y. (2016) Beneficial effects of Glycyrrhizae radix extract in preventing oxidative damage and extending the lifespan of Caenorhabditis elegans. J Ethnopharmacol 177: 101–110
Ren M-X, Zhao L, Ding X-C, Krasteva N, Rui Q, Wang D-Y (2018) Developmental basis for intestinal barrier against the toxicity of graphene oxide. Part Fibre Toxicol 15:26
Qu M, Xu K-N, Li Y-H, Wong G, Wang D-Y (2018) Using acs-22 mutant Caenorhabditis elegans to detect the toxicity of nanopolystyrene particles. Sci Total Environ 643:119–126
Zhi L-T, Fu W, Wang X, Wang D-Y (2016) ACS-22, a protein homologous to mammalian fatty acid transport protein 4, is essential for the control of toxicity and translocation of multi-walled carbon nanotubes in Caenorhabditis elegans. RSC Adv 6:4151–4159
Zhao Y-L, Yu X-M, Jia R-H, Yang R-L, Rui Q, Wang D-Y (2015) Lactic acid bacteria protects Caenorhabditis elegans from toxicity of graphene oxide by maintaining normal intestinal permeability under different genetic backgrounds. Sci Rep 5:17233
Zhao Y-L, Zhi L-T, Wu Q-L, Yu Y-L, Sun Q-Q, Wang D-Y (2016) p38 MAPK-SKN-1/Nrf signaling cascade is required for intestinal barrier against graphene oxide toxicity in Caenorhabditis elegans. Nanotoxicology 10:1469–1479
Chisholm AD, Hardin J (2005) Epidermal morphogenesis. WormBook. https://doi.org/10.1895/wormbook.1.35.1
Chisholm AD, Hsiao TI (2012) The C. elegans epidermis as a model skin. I: development, patterning, and growth. Wiley Interdiscip Rev Dev Biol 1:861–878
Chisholm AD, Xu S (2012) The C. elegans epidermis as a model skin. II: differentiation and physiological roles. Wiley Interdiscip Rev Dev Biol 1:879–902
Chin-Sang ID, Chisholm AD (2000) Form of the worm: genetics of epidermal morphogenesis in C. elegans. Trends Genet 16:544–551
Kage-Nakadai E, Kobuna H, Kimura M, Gengyo-Ando K, Inoue T, Arai H, Mitani S (2010) Two very long chain fatty acid acyl-CoA synthetase genes, acs-20 and acs-22, have roles in the cuticle surface barrier in Caenorhabditis elegans. PLoS One 5:e8857
Wu Q-L, Rui Q, He K-W, Shen L-L, Wang D-Y (2010) UNC-64 and RIC-4, the plasma membrane associated SNAREs syntaxin and SNAP-25, regulate fat storage in nematode Caenorhabditis elegans. Neurosci Bull 26:104–116
Zhao Y-L, Wu Q-L, Li Y-P, Wang D-Y (2013) Translocation, transfer, and in vivo safety evaluation of engineered nanomaterials in the non-mammalian alternative toxicity assay model of nematode Caenorhabditis elegans. RSC Adv 3:5741–5757
Shao H-M, Han Z-Y, Krasteva N, Wang D-Y (2018) Identification of signaling cascade in the insulin signaling pathway in response to nanopolystyrene particles. Nanotoxicology. https://doi.org/10.1080/17435390.2018.1530395
Wang Q-Q, Zhao S-Q, Zhao Y-L, Rui Q, Wang D-Y (2014) Toxicity and translocation of graphene oxide in Arabidopsis plants under stress conditions. RSC Adv 4:60891–60901
Thein MC, Winter AD, Stepek G, McCormack G, Stapleton G, Johnstone IL, Page AP (2009) Combined extracellular matrix cross-linking activity of the peroxidase MLT-7 and the dual oxidase BLI-3 is critical for post-embryonic viability in Caenorhabditis elegans. J Biol Chem 284:17549–17563
Ding X-C, Rui Q, Wang D-Y (2018) Functional disruption in epidermal barrier enhances toxicity and accumulation of graphene oxide. Ecotoxicol Environ Saf 163:456–464
Wu Q-L, Zhao Y-L, Fang J-P, Wang D-Y (2014) Immune response is required for the control of in vivo translocation and chronic toxicity of graphene oxide. Nanoscale 6:5894–5906
Wu Q-L, Zhou X-F, Han X-X, Zhuo Y-Z, Zhu S-T, Zhao Y-L, Wang D-Y (2016) Genome-wide identification and functional analysis of long noncoding RNAs involved in the response to graphene oxide. Biomaterials 102:277–291
Zhao L, Kong J-T, Krasteva N, Wang D-Y (2018) Deficit in epidermal barrier induces toxicity and translocation of PEG modified graphene oxide in nematodes. Toxicol Res 7:1061–1070
Zhao L, Dong S-S, Zhao Y-L, Shao H-M, Krasteva N, Wu Q-L, Wang D-Y (2019) Dysregulation of let-7 by PEG modified graphene oxide in nematodes with deficit in epidermal barrier. Ecotoxicol Environ Saf 169:1–7
Ding X-C, Rui Q, Zhao Y-L, Shao H-M, Yin Y-P, Wu Q-L, Wang D-Y (2018) Toxicity of graphene oxide in nematodes with deficit in epidermal barrier caused by RNA interference knockdown of unc-52. Environ Sci Technol Lett. https://doi.org/10.1021/acs.estlett.8b00473
Moribe H, Yochem J, Yamada H, Tabuse Y, Fujimoto T, Mekada E (2004) Tetraspanin protein (TSP-15) is required for epidermal integrity in Caenorhabditis elegans. J Cell Sci 117:5209–5220
Xu Z, Luo J, Li Y, Ma L (2015) The BLI-3/TSP-15/DOXA-1 dual oxidase complex is required for iodide toxicity in Caenorhabditis elegans. G3 5:195–203
Tong A, Lynn G, Ngo V, Wong D, Moseley SL, Ewbank JJ, Goncharov A, Wu Y, Pujol N, Chisholm AD (2009) Negative regulation of Caenorhabditis elegans epidermal damage responses by death-associated protein kinase. Proc Natl Acad Sci U S A 106:1457–1461
Chuang M, Hsiao TI, Tong A, Xu S, Chisholm AD (2016) DAPK interacts with Patronin and the microtubule cytoskeleton in epidermal development and wound repair. eLife 5:e15833
Zhang Y, Li W, Li L, Li Y, Fu R, Zhu Y, Li J, Zhou Y, Xiong S, Zhang H (2015) Structural damage in the C. elegans epidermis causes release of STA-2 and induction of an innate immune response. Immunity 42:309–320
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Wang, D. (2019). Epidermal Barrier for Nematodes Against Toxicity of Environmental Toxicants or Stresses. In: Target Organ Toxicology in Caenorhabditis elegans. Springer, Singapore. https://doi.org/10.1007/978-981-13-6010-7_4
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DOI: https://doi.org/10.1007/978-981-13-6010-7_4
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