Skip to main content
SpringerLink
Log in

Circular RNA in Aging and Age-Related Diseases

  • Chapter
  • First Online:
Aging and Aging-Related Diseases

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1086))

Abstract

Circular RNAs (circRNAs) are widely present and participate in a variety of biological regulatory activities as a novel type of endogenous noncoding RNA molecule. With advances in RNA structure and function analysis, it was found that circRNAs are present in a myriad of life processes and longevity in model organisms such as mice, flies, and worms. Accumulating evidence indicates the involvement of circRNAs in regulation of age-related pathologies such as cancer, diabetes, cardiovascular disorders, and neurodegenerative disease, suggesting that circRNAs may have great potential implications in clinical and research fields. In this chapter, we review recent advances in circRNA functions and mechanisms and discuss their roles in aging and age-related diseases. It will provide insight into the regulatory roles of circRNAs in aging and age-related diseases.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 129.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 179.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Abdelmohsen K, Panda AC, De S, Grammatikakis I, Kim J, Ding J, Noh JH, Kim KM, Mattison JA, de Cabo R, Gorospe M (2015) Circular RNAs in monkey muscle: age-dependent changes. Aging (Albany NY) 7:903–910

    Article  CAS  Google Scholar 

  • Abdelmohsen K, Panda AC, Munk R, Grammatikakis I, Dudekula DB, De S, Kim J, Noh JH, Kim KM, Martindale JL, Gorospe M (2017) Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by CircPABPN1. RNA Biol 14:361–369

    Article  PubMed  PubMed Central  Google Scholar 

  • Ashwal-Fluss R, Meyer M, Pamudurti NR, Ivanov A, Bartok O, Hanan M, Evantal N, Memczak S, Rajewsky N, Kadener S (2014) circRNA biogenesis competes with pre-mRNA splicing. Mol Cell 56:55–66

    Article  CAS  PubMed  Google Scholar 

  • Baker DJ, Childs BG, Durik M, Wijers ME, Sieben CJ, Zhong J, Saltness RA, Jeganathan KB, Verzosa GC, Pezeshki A, Khazaie K, Miller JD, van Deursen JM (2016) Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan. Nature 530:184–189

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bazan HA, Lightell D, Sternbergh WC, Woods TC (2014) Recently ruptured carotid plaques have increased levels of circular RNA-16, which negatively regulates the proproliferative and antiapoptotic microRNA-221: a novel mediator of carotid plaque rupture. Arterioscler Thromb Vasc Biol 34:A123

    Article  Google Scholar 

  • Bingol B, Sheng M (2011) Deconstruction for reconstruction: the role of proteolysis in neural plasticity and disease. Neuron 69:22–32

    Article  CAS  PubMed  Google Scholar 

  • Bloomgarden Z, Ning G (2013) Diabetes and aging. J Diabetes 5:369–371

    Article  PubMed  Google Scholar 

  • Brown JB, Boley N, Eisman R, May GE, Stoiber MH, Duff MO, Booth BW, Wen J, Park S, Suzuki AM, Wan KH, Yu C, Zhang D, Carlson JW, Cherbas L, Eads BD, Miller D, Mockaitis K, Roberts J, Davis CA, Frise E, Hammonds AS, Olson S, Shenker S, Sturgill D, Samsonova AA, Weiszmann R, Robinson G, Hernandez J, Andrews J, Bickel PJ, Carninci P, Cherbas P, Gingeras TR, Hoskins RA, Kaufman TC, Lai EC, Oliver B, Perrimon N, Graveley BR, Celniker SE (2014) Diversity and dynamics of the Drosophila transcriptome. Nature 512:393–399

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Calarco JA, Superina S, O’Hanlon D, Gabut M, Raj B, Pan Q, Skalska U, Clarke L, Gelinas D, van der Kooy D, Zhen M, Ciruna B, Blencowe BJ (2009) Regulation of vertebrate nervous system alternative splicing and development by an SR-related protein. Cell 138:898–910

    Article  CAS  PubMed  Google Scholar 

  • Chen J, Li Y, Zheng Q, Bao C, He J, Chen B, Lyu D, Zheng B, Xu Y, Long Z, Zhou Y, Zhu H, Wang Y, He X, Shi Y, Huang S (2017a) Circular RNA profile identifies circPVT1 as a proliferative factor and prognostic marker in gastric cancer. Cancer Lett 388:208–219

    Article  CAS  PubMed  Google Scholar 

  • Chen L, Zhang S, Wu J, Cui J, Zhong L, Zeng L, Ge S (2017b) circRNA_100290 plays a role in oral cancer by functioning as a sponge of the miR-29 family. Oncogene 36:4551–4561

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Chen S, Li T, Zhao Q, Xiao B, Guo J (2017c) Using circular RNA hsa_circ_0000190 as a new biomarker in the diagnosis of gastric cancer. Clin Chim Acta 466:167–171

    Article  CAS  PubMed  Google Scholar 

  • Cogswell JP, Ward J, Taylor IA, Waters M, Shi Y, Cannon B, Kelnar K, Kemppainen J, Brown D, Chen C, Prinjha RK, Richardson JC, Saunders AM, Roses AD, Richards CA (2008) Identification of miRNA changes in Alzheimer’s disease brain and CSF yields putative biomarkers and insights into disease pathways. J Alzheimers Dis 14:27–41

    Article  CAS  PubMed  Google Scholar 

  • Colangelo V, Schurr J, Ball MJ, Pelaez RP, Bazan NG, Lukiw WJ (2002) Gene expression profiling of 12633 genes in Alzheimer hippocampal CA1: transcription and neurotrophic factor down-regulation and up-regulation of apoptotic and pro-inflammatory signaling. J Neurosci Res 70:462–473

    Article  CAS  PubMed  Google Scholar 

  • Cortés-López M, Gruner MR, Cooper DA, Gruner HN, Voda AI, van der Linden AM, Miura P (2018) Global accumulation of circRNAs during aging in Caenorhabditis elegans. BMC Genomics 19:8

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Creighton CJ, Benham AL, Zhu H, Khan MF, Reid JG, Nagaraja AK, Fountain MD, Dziadek O, Han D, Ma L, Kim J, Hawkins SM, Anderson ML, Matzuk MM, Gunaratne PH (2010) Discovery of novel microRNAs in female reproductive tract using next generation sequencing. PLoS One 5:e9637

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Cummins JM, He Y, Leary RJ, Pagliarini R, Diaz LA Jr, Sjoblom T, Barad O, Bentwich Z, Szafranska AE, Labourier E, Raymond CK, Roberts BS, Juhl H, Kinzler KW, Vogelstein B, Velculescu VE (2006) The colorectal microRNAome. Proc Natl Acad Sci U S A 103:3687–3692

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Dang RY, Liu FL, Li Y (2017) Circular RNA hsa_circ_0010729 regulates vascular endothelial cell proliferation and apoptosis by targeting the miR-186/HIF-1alpha axis. Biochem Biophys Res Commun 490:104–110

    Article  CAS  PubMed  Google Scholar 

  • De A, Ghosh C (2017) Basics of aging theories and disease related aging-an overview. Pharma Tutor 5:16–23

    CAS  Google Scholar 

  • Du WW, Yang W, Chen Y, Wu ZK, Foster FS, Yang Z, Li X, Yang BB (2016) Foxo3 circular RNA promotes cardiac senescence by modulating multiple factors associated with stress and senescence responses. Eur Heart J 38:1402–1412

    Google Scholar 

  • Elia L, Quintavalle M, Condorelli G (2017) Circular RNAs and heart failure: new players for an old disease. Cardiovasc Res 113:254–255

    Article  CAS  PubMed  Google Scholar 

  • Fu LY, Chen QQ, Yao T, Li TW, Ying S, Hu YR, Guo JM (2017a) Hsa_circ_0005986 inhibits carcinogenesis by acting as a miR-129-5p sponge and is used as a novel biomarker for hepatocellular carcinoma. Oncotarget 8:43878–43888

    Article  PubMed  PubMed Central  Google Scholar 

  • Fu LY, Yao T, Chen QQ, Mo XY, Hu YR, Guo JM (2017b) Screening differential circular RNA expression profiles reveals hsa_circ_0004018 is associated with hepatocellular carcinoma. Oncotarget 8:58405–58416

    Article  PubMed  PubMed Central  Google Scholar 

  • Fu L, Wu S, Yao T, Chen Q, Xie Y, Ying S, Chen Z, Xiao B, Hu Y (2018) Decreased expression of hsa_circ_0003570 in hepatocellular carcinoma and its clinical significance. J Clin Lab Anal 32(2). https://doi.org/10.1002/jcla.22239

    Article  PubMed Central  CAS  Google Scholar 

  • Garikipati VN, Verma SK, Cheng ZJ, Nickoloff E, Liang DM, Khan M, Benedict C, Cimini M, Ibetti J, Grisanti LA, Schumacher SM, Gao E, Rabinowitz JE, Wilusz JE, Goukassian D, Houser SR, Koch WJ, Kishore R (2016) mmu_circ_008396 a novel circular RNA involved in myocardial infarction. Circulation 134:A19454

    Google Scholar 

  • Gems D, Partridge L (2013) Genetics of longevity in model organisms: debates and paradigm shifts. Annu Rev Physiol 75:621–644

    Article  CAS  PubMed  Google Scholar 

  • Geng HH, Li R, Su YM, Xiao J, Pan M, Cai XX, Ji XP (2016) The circular RNA Cdr1as promotes myocardial infarction by mediating the regulation of miR-7a on its target genes expression. PLoS One 11:e0151753

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Ginsberg SD, Alldred MJ, Che S (2012) Gene expression levels assessed by CA1 pyramidal neuron and regional hippocampal dissections in Alzheimer’s disease. Neurobiol Dis 45:99–107

    Article  CAS  PubMed  Google Scholar 

  • Gruner H, Cortes-Lopez M, Cooper DA, Bauer M, Miura P (2016) CircRNA accumulation in the aging mouse brain. Sci Rep 6:38907

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Guarnerio J, Bezzi M, Jeong JC, Paffenholz SV, Berry K, Naldini MM, Lo-Coco F, Tay Y, Beck AH, Pandolfi PP (2016) Oncogenic role of fusion-circRNAs derived from cancer-associated chromosomal translocations. Cell 165:289–302

    Article  CAS  PubMed  Google Scholar 

  • Guo JU, Agarwal V, Guo H, Bartel DP (2014) Expanded identification and characterization of mammalian circular RNAs. Genome Biol 15:409

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Guo JN, Li J, Zhu CL, Feng WT, Shao JX, Wan L, Huang MD, He JD (2016) Comprehensive profile of differentially expressed circular RNAs reveals that hsa_circ_0000069 is up-regulated and promotes cell proliferation, migration, and invasion in colorectal cancer. Onco Targets Ther 9:7451–7458

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hansen TB, Jensen TI, Clausen BH, Bramsen JB, Finsen B, Damgaard CK, Kjems J (2013) Natural RNA circles function as efficient microRNA sponges. Nature 495:384–388

    Article  CAS  PubMed  Google Scholar 

  • Holdt LM, Stahringer A, Sass K, Pichler G, Kulak NA, Wilfert W, Kohlmaier A, Herbst A, Northoff BH, Nicolaou A, Gabel G, Beutner F, Scholz M, Thiery J, Musunuru K, Krohn K, Mann M, Teupser D (2016) Circular non-coding RNA ANRIL modulates ribosomal RNA maturation and atherosclerosis in humans. Nat Commun 7:12429

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Huang G, Li S, Yang N, Zou Y, Zheng D, Xiao T (2017) Recent progress in circular RNAs in human cancers. Cancer Lett 404:8–18

    Article  CAS  PubMed  Google Scholar 

  • Jeck WR, Sharpless NE (2014) Detecting and characterizing circular RNAs. Nat Biotechnol 32:453–461

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Jeck WR, Sorrentino JA, Wang K, Slevin MK, Burd CE, Liu J, Marzluff WF, Sharpless NE (2013) Circular RNAs are abundant, conserved, and associated with ALU repeats. RNA 19:141–157

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Jiang G, Ma Y, An T, Pan Y, Mo F, Zhao D, Liu Y, Miao JN, Gu YJ, Wang Y, Gao SH (2017) Relationships of circular RNA with diabetes and depression. Sci Rep 7:7285

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Jin H, Fang MF, Man ZR, Wang Y, Liu HC (2017a) Circular RNA 001569 acts as an oncogene and correlates with aggressive characteristics in hepatocellular carcinoma. Int J Clin Exp Pathol 10:2997–3005

    CAS  Google Scholar 

  • Jin H, Jin X, Zhang H, Wang W (2017b) Circular RNA hsa-circ-0016347 promotes proliferation, invasion and metastasis of osteosarcoma cells. Oncotarget 8:25571–25581

    Article  PubMed  PubMed Central  Google Scholar 

  • Karakelides H, Nair KS (2005) Sarcopenia of aging and its metabolic impact. Curr Top Dev Biol 68:123–148

    Article  CAS  PubMed  Google Scholar 

  • Li Z, Huang C, Bao C, Chen L, Lin M, Wang X, Zhong G, Yu B, Hu W, Dai L, Zhu P, Chang Z, Wu Q, Zhao Y, Jia Y, Xu P, Liu H, Shan G (2015) Exon-intron circular RNAs regulate transcription in the nucleus. Nat Struct Mol Biol 22:256–264

    Article  PubMed  CAS  Google Scholar 

  • Li P, Chen H, Chen S, Mo X, Li T, Xiao B, Yu R, Guo J (2017a) Circular RNA 0000096 affects cell growth and migration in gastric cancer. Br J Cancer 116:626–633

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Li W, Zhong C, Jiao J, Li P, Cui B, Ji C, Ma D (2017b) Characterization of hsa_circ_0004277 as a new biomarker for acute myeloid leukemia via circular RNA profile and bioinformatics analysis. Int J Mol Sci 18:59

    Google Scholar 

  • Li WH, Song YC, Zhang H, Zhou ZJ, Xie X, Zeng QN, Guo K, Wang T, Xia P, Chang DM (2017c) Decreased expression of Hsa_circ_00001649 in gastric cancer and its clinical significance. Dis Markers 2017:4587698

    PubMed  PubMed Central  Google Scholar 

  • Li X, Zhao Z, Jian D, Li W, Tang H, Li M (2017d) Hsa-circRNA11783-2 in peripheral blood is correlated with coronary artery disease and type 2 diabetes mellitus. Diab Vasc Dis Res 1–6. 1479164117722714

    Google Scholar 

  • Lipska KJ, Krumholz H, Soones T, Lee SJ (2016) Polypharmacy in the aging patient: a review of glycemic control in older adults with type 2 diabetes. JAMA 315:1034–1045

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Liu JW, Chen LL (2015) Analysis of circular RNA in Caenorhabditis elegans. Hans J Comput Biol 5:17–28

    Article  Google Scholar 

  • Liu C, Yao MD, Li CP, Shan K, Yang H, Wang JJ, Liu B, Li XM, Yao J, Jiang Q, Yan B (2017) Silencing of circular RNA-ZNF609 ameliorates vascular endothelial dysfunction. Theranostics 7:2863–2877

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lonskaya I, Shekoyan AR, Hebron ML, Desforges N, Algarzae NK, Moussa CE (2013) Diminished parkin solubility and co-localization with intraneuronal amyloid-beta are associated with autophagic defects in Alzheimer’s disease. J Alzheimers Dis 33:231–247

    Article  CAS  PubMed  Google Scholar 

  • Loring JF, Wen X, Lee JM, Seilhamer J, Somogyi R (2001) A gene expression profile of Alzheimer’s disease. DNA Cell Biol 20:683–695

    Article  CAS  PubMed  Google Scholar 

  • Lu WY (2017) Roles of the circular RNA circ-Foxo3 in breast cancer progression. Cell Cycle 16:589–590

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lukiw WJ (2013) Circular RNA (circRNA) in Alzheimer’s disease (AD). Front Genet 4:307

    PubMed  PubMed Central  Google Scholar 

  • Lukiw WJ, Andreeva TV, Grigorenko AP, Rogaev EI (2012) Studying micro RNA function and dysfunction in Alzheimer’s disease. Front Genet 3:327

    Article  PubMed  Google Scholar 

  • Memczak S, Jens M, Elefsinioti A, Torti F, Krueger J, Rybak A, Maier L, Mackowiak SD, Gregersen LH, Munschauer M, Loewer A, Ziebold U, Landthaler M, Kocks C, le Noble F, Rajewsky N (2013) Circular RNAs are a large class of animal RNAs with regulatory potency. Nature 495:333–338

    Article  CAS  PubMed  Google Scholar 

  • Meng S, Zhou H, Feng Z, Xu Z, Tang Y, Li P, Wu M (2017) CircRNA: functions and properties of a novel potential biomarker for cancer. Mol Cancer 16:94

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Ng SY, Bogu GK, Soh BS, Stanton LW (2013) The long noncoding RNA RMST interacts with SOX2 to regulate neurogenesis. Mol Cell 51:349–359

    Article  CAS  PubMed  Google Scholar 

  • Panda AC, Grammatikakis I, Kim KM, De S, Martindale JL, Munk R, Yang X, Abdelmohsen K, Gorospe M (2016) Identification of senescence-associated circular RNAs (SAC-RNAs) reveals senescence suppressor CircPVT1. Nucleic Acids Res 45:4021–4035

    Article  PubMed Central  CAS  Google Scholar 

  • Parish ST, Wu JE, Effros RB (2010) Sustained CD28 expression delays multiple features of replicative senescence in human CD8 T lymphocytes. J Clin Immunol 30:798–805

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Qin M, Liu G, Huo X, Tao X, Sun X, Ge Z, Yang J, Fan J, Liu L, Qin W (2016) Hsa_circ_0001649: a circular RNA and potential novel biomarker for hepatocellular carcinoma. Cancer Biomark 16:161–169

    Article  CAS  PubMed  Google Scholar 

  • Qu S, Zhong Y, Shang R, Zhang X, Song W, Kjems J, Li H (2016) The emerging landscape of circular RNA in life processes. RNA Biol 14:992–999

    Article  PubMed  PubMed Central  Google Scholar 

  • Rybak-Wolf A, Stottmeister C, Glazar P, Jens M, Pino N, Giusti S, Hanan M, Behm M, Bartok O, Ashwal-Fluss R, Herzog M, Schreyer L, Papavasileiou P, Ivanov A, Ohman M, Refojo D, Kadener S, Rajewsky N (2015) Circular RNAs in the mammalian brain are highly abundant, conserved, and dynamically expressed. Mol Cell 58:870–885

    Article  CAS  PubMed  Google Scholar 

  • Salzman J, Chen RE, Olsen MN, Wang PL, Brown PO (2013) Cell-type specific features of circular RNA expression. PLoS Genet 9:e1003777

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Shan K, Liu C, Liu BH, Chen X, Dong R, Liu X, Zhang YY, Liu B, Zhang SJ, Wang JJ, Zhang SH, Wu JH, Zhao C, Yan B (2017) Circular non-coding RNA HIPK3 mediates retinal vascular dysfunction in diabetes mellitus. Circulation 136:1629–1642

    Article  CAS  PubMed  Google Scholar 

  • Shang X, Li G, Liu H, Li T, Liu J, Zhao Q, Wang C (2016) Comprehensive circular RNA profiling reveals that hsa_circ_0005075, a new circular RNA biomarker, is involved in hepatocellular carcinoma development. Medicine (Baltimore) 95:e3811

    Article  CAS  Google Scholar 

  • Shao Y, Chen L, Lu R, Zhang X, Xiao B, Ye G, Guo J (2017a) Decreased expression of hsa_circ_0001895 in human gastric cancer and its clinical significances. Tumour Biol 39:1010428317699125

    Article  CAS  Google Scholar 

  • Shao YF, Yang YB, Lu RD, Xiao BX, Ye GL, Guo JM (2017b) Identification of tissue-specific circRNA hsa_circ_0000705 as an indicator for human gastric cancer. Int J Clin Exp Pathol 10:3151–3156

    CAS  Google Scholar 

  • Szabo L, Morey R, Palpant NJ, Wang PL, Afari N, Jiang C, Parast MM, Murry CE, Laurent LC, Salzman J (2015) Statistically based splicing detection reveals neural enrichment and tissue-specific induction of circular RNA during human fetal development. Genome Biol 16:126

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Tang CM, Zhang M, Huang L, Hu ZQ, Zhu JN, Xiao Z, Zhang Z, Lin QX, Zheng XL, Yang M, Wu SL, Cheng JD, Shan ZX (2017a) CircRNA_000203 enhances the expression of fibrosis-associated genes by derepressing targets of miR-26b-5p, Col1a2 and CTGF, in cardiac fibroblasts. Sci Rep 7:40342

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Tang W, Ji M, He G, Yang L, Niu Z, Jian M, Wei Y, Ren L, Xu J (2017b) Silencing CDR1as inhibits colorectal cancer progression through regulating microRNA-7. Onco Targets Ther 10:2045–2056

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Tchkonia T, Zhu Y, van Deursen J, Campisi J, Kirkland JL (2013) Cellular senescence and the senescent secretory phenotype: therapeutic opportunities. J Clin Invest 123:966–972

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Tosato M, Zamboni V, Ferrini A, Cesari M (2007) The aging process and potential interventions to extend life expectancy. Clin Interv Aging 2:401–412

    PubMed  PubMed Central  Google Scholar 

  • Wang PL, Bao Y, Yee MC, Barrett SP, Hogan GJ, Olsen MN, Dinneny JR, Brown PO, Salzman J (2014) Circular RNA is expressed across the eukaryotic tree of life. PLoS One 9:e90859

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Wang X, Zhang Y, Huang L, Zhang J, Pan F, Li B, Yan Y, Jia B, Liu H, Li S, Zheng W (2015a) Decreased expression of hsa_circ_001988 in colorectal cancer and its clinical significances. Int J Clin Exp Pathol 8:16020–16025

    CAS  PubMed  PubMed Central  Google Scholar 

  • Wang YH, Yu XH, Luo SS, Han H (2015b) Comprehensive circular RNA profiling reveals that circular RNA100783 is involved in chronic CD28-associated CD8(+)T cell ageing. Immun Ageing 12:17

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wang K, Long B, Liu F, Wang JX, Liu CY, Zhao B, Zhou LY, Sun T, Wang M, Yu T, Gong Y, Liu J, Dong YH, Li N, Li PF (2016) A circular RNA protects the heart from pathological hypertrophy and heart failure by targeting miR-223. Eur Heart J 37:2602–2611

    Article  CAS  PubMed  Google Scholar 

  • Wang K, Sun Y, Tao W, Fei X, Chang C (2017) Androgen receptor (AR) promotes clear cell renal cell carcinoma (ccRCC) migration and invasion via altering the circHIAT1/miR-195-5p/29a-3p/29c-3p/CDC42 signals. Cancer Lett 394:1–12

    Google Scholar 

  • Westholm JO, Miura P, Olson S, Shenker S, Joseph B, Sanfilippo P, Celniker SE, Graveley BR, Lai EC (2014) Genome-wide analysis of Drosophila circular RNAs reveals their structural and sequence properties and age-dependent neural accumulation. Cell Rep 9:1966–1980

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Xia WJ, Qiu MT, Chen R, Wang SW, Leng XC, Wang J, Xu YT, Hu LW, Dong GC, Xu PL, Yin R (2016) Circular RNA has_circ_0067934 is up-regulated in esophageal squamous cell carcinoma and promoted proliferation. Sci Rep 6:35576

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Xie H, Ren X, Xin S, Lan X, Lu G, Lin Y, Yang S, Zeng Z, Liao W, Ding YQ, Liang L (2016) Emerging roles of circRNA_001569 targeting miR-145 in the proliferation and invasion of colorectal cancer. Oncotarget 7:26680–26691

    Article  PubMed  PubMed Central  Google Scholar 

  • Xu H, Guo S, Li W, Yu P (2015) The circular RNA Cdr1as, via miR-7 and its targets, regulates insulin transcription and secretion in islet cells. Sci Rep 5:12453

    Article  PubMed  PubMed Central  Google Scholar 

  • Xu L, Zhang M, Zheng X, Yi P, Lan C, Xu M (2017) The circular RNA ciRS-7 (Cdr1as) acts as a risk factor of hepatic microvascular invasion in hepatocellular carcinoma. J Cancer Res Clin Oncol 143:17–27

    Article  PubMed  CAS  Google Scholar 

  • Xuan L, Qu L, Zhou H, Wang P, Yu H, Wu T, Wang X, Li Q, Tian L, Liu M, Sun Y (2016) Circular RNA: a novel biomarker for progressive laryngeal cancer. Am J Transl Res 8:932–939

    CAS  PubMed  PubMed Central  Google Scholar 

  • Xue J, Liu Y, Luo F, Lu X, Xu H, Liu X, Lu L, Yang Q, Chen C, Fan W, Liu Q (2017) Circ100284, via miR-217 regulation of EZH2, is involved in the arsenite-accelerated cell cycle of human keratinocytes in carcinogenesis. Biochim Biophys Acta 1863:753–763

    Article  CAS  Google Scholar 

  • Yang D, Lian T, Tu J, Gaur U, Mao X, Fan X, Li D, Li Y, Yang M (2016) LncRNA mediated regulation of aging pathways in Drosophila melanogaster during dietary restriction. Aging (Albany NY) 8:2182–2203

    Article  CAS  Google Scholar 

  • Yang Y, Fan X, Mao M, Song X, Wu P, Zhang Y, Jin Y, Yang Y, Chen LL, Wang Y, Wong CC, Xiao X, Wang Z (2017) Extensive translation of circular RNAs driven by N6-methyladenosine. Cell Res 27:626–641

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Yao Z, Luo J, Hu K, Lin J, Huang H, Wang Q, Zhang P, Xiong Z, He C, Huang Z, Liu B, Yang Y (2017a) ZKSCAN1 gene and its related circular RNA (circZKSCAN1) both inhibit hepatocellular carcinoma cell growth, migration, and invasion but through different signaling pathways. Mol Oncol 11:422–437

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Yao JT, Zhao SH, Liu QP, Lv MQ, Zhou DX, Liao ZJ, Nan KJ (2017b) Over-expression of CircRNA_100876 in non-small cell lung cancer and its prognostic value. Pathol Res Pract 213:453–456

    Article  CAS  PubMed  Google Scholar 

  • Zhao Z, Li X, Gao C, Jian D, Hao P, Rao L, Li M (2017a) Peripheral blood circular RNA hsa_circ_0124644 can be used as a diagnostic biomarker of coronary artery disease. Sci Rep 7:39918

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Zhao Z, Li X, Jian D, Hao P, Rao L, Li M (2017b) Hsa_circ_0054633 in peripheral blood can be used as a diagnostic biomarker of pre-diabetes and type 2 diabetes mellitus. Acta Diabetol 54:237–245

    Article  CAS  PubMed  Google Scholar 

  • Zheng C, Niu H, Li M, Zhang H, Yang Z, Tian L, Wu Z, Li D, Chen X (2015) Cyclic RNA hsa-circ-000595 regulates apoptosis of aortic smooth muscle cells. Mol Med Rep 12:6656–6662

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Zheng J, Liu X, Xue Y, Gong W, Ma J, Xi Z, Que Z, Liu Y (2017) TTBK2 circular RNA promotes glioma malignancy by regulating miR-217/HNF1beta/Derlin-1 pathway. J Hematol Oncol 10:52

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Zhong Z, Lv M, Chen J (2016) Screening differential circular RNA expression profiles reveals the regulatory role of circTCF25-miR-103a-3p/miR-107-CDK6 pathway in bladder carcinoma. Sci Rep 6:30919

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Zhou B, Yu JW (2017) A novel identified circular RNA, circRNA_010567, promotes myocardial fibrosis via suppressing miR-141 by targeting TGF-b1. Biochem Biophys Res Commun 487:769–775

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgments

This work was supported by the National Natural Science Foundation of China (No. 31771338 and No. 31471998).

Author information

Authors and Affiliations

  1. Institute of Animal Genetics and Breeding, Sichuan Agricultural University, Chengdu, China

    Deying Yang & Mingyao Yang

  2. Addenbrooke’s Hospital, Cambridge University Hospital, Cambridge Biomedical Campus, Cambridge, UK

    Katie Yang

Authors
  1. Deying Yang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Katie Yang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Mingyao Yang
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Mingyao Yang .

Editor information

Editors and Affiliations

  1. School of Pharmaceutical Sciences, Tsinghua University, Beijing, China

    Zhao Wang

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer Nature Singapore Pte Ltd.

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Yang, D., Yang, K., Yang, M. (2018). Circular RNA in Aging and Age-Related Diseases. In: Wang, Z. (eds) Aging and Aging-Related Diseases. Advances in Experimental Medicine and Biology, vol 1086. Springer, Singapore. https://doi.org/10.1007/978-981-13-1117-8_2

Download citation

Publish with us

Policies and ethics

Search

Navigation