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Mushrooms: A Pandora Box of Cardioprotective Phytochemicals

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Medicinal Plants and Fungi: Recent Advances in Research and Development

Part of the book series: Medicinal and Aromatic Plants of the World ((MAPW,volume 4))

Abstract

Overwhelming consensus among medical authorities and scholarly bodies on the high susceptibility to chronic ailments such as coronary diseases, cancers, and diabetes and the failure to make any leap forward progress in controlling casualties or even to completely understand their pathology is a frightening reality. To comprehend alterations, additions, and management of diet is a preferable approach not only to prevent the occurrence of cardiovascular diseases but also to precise and enhance treatment measures. Proper application of potential drugs is possible only by establishing a systemic correlation and compilation of the knowledge obtained on the possible bioactive drugs. In this perspective gathering knowledge on the health-promoting potential of mushrooms which are considered as one of the promising sources of potential products that provide cardioprotection is indispensable. While there are several mushrooms traditionally utilized around the world for the treatment of cardiovascular diseases (CVD), they are also being cautiously evaluated experimentally for the available evidences of ethnopharmacology. Some therapeutic mushrooms have preclinical studies to demonstrate that uptake of these organic dietary supplements and their constituents as a therapeutic alternative or supplement is conceivable, and further evaluations are carried out to help in lessening the prevalence and mortality of CVD by incorporating them either as a population medicine or as a clinical medicine. A few examinations have demonstrated the effect of mushrooms and their bioactive compounds on metabolic markers such as low-density lipoprotein, high-density lipoprotein, total cholesterol, fasting triacylglycerol, and homocysteine levels and on conditions such as hypertension, body hemostasis, oxidative stress, and inflammation which are associated with cardiovascular ailments. The focus of this chapter will primarily be on mushrooms used traditionally for the treatment of CVD.

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Abbreviations

ACE:

Angiotensin I-converting enzyme

CVD:

Cardiovascular diseases

HDL :

High-density lipoprotein

LDL:

Low-density lipoprotein

RAS:

Renin-angiotensin system

STZ:

Streptozotocin

VLDL:

Low-density lipoprotein

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Authors and Affiliations

  1. Graduate Institute of Basic Medical Science, School of Chinese Medicine, China Medical University and Hospital, Taichung, Taiwan

    Marthandam Asokan Shibu & Chih-Yang Huang

  2. Department of Applied Chemistry, Chaoyang University of Technology, Taichung, Taiwan

    Dinesh Chandra Agrawal

  3. School of Chinese Medicine, China Medical University, Taichung, Taiwan

    Chih-Yang Huang

  4. Department of Health and Nutrition Biotechnology, Asia University, Taichung, Taiwan

    Chih-Yang Huang

Authors
  1. Marthandam Asokan Shibu
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  2. Dinesh Chandra Agrawal
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  3. Chih-Yang Huang
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Correspondence to Marthandam Asokan Shibu .

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Editors and Affiliations

  1. Department of Applied Chemistry, Chaoyang University of Technology, Taichung, Taiwan

    Dinesh Chandra Agrawal

  2. Department of Applied Chemistry, Chaoyang University of Technology, Taichung, Taiwan

    Hsin-Sheng Tsay

  3. Agricultural Biotechnology Research Center, Academia Sinica, Taipei, Taiwan

    Lie-Fen Shyur

  4. Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung, Taiwan

    Yang-Chang Wu

  5. Department of Forestry, National Chung Hsing University, Taichung, Taiwan

    Sheng-Yang Wang

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Shibu, M.A., Agrawal, D.C., Huang, CY. (2017). Mushrooms: A Pandora Box of Cardioprotective Phytochemicals. In: Agrawal, D., Tsay, HS., Shyur, LF., Wu, YC., Wang, SY. (eds) Medicinal Plants and Fungi: Recent Advances in Research and Development. Medicinal and Aromatic Plants of the World, vol 4. Springer, Singapore. https://doi.org/10.1007/978-981-10-5978-0_11

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