Abstract
Thanks to their unique properties, inorganic nanostructures have become the center of modern material science. Among existing nanomaterials, magnetic iron oxide nanoparticles (IONP) have attracted a lot of interest. These nanoparticles are suitable for many technological applications such as contrast agent for magnetic resonance imaging. When comparing to molecular MRI probes (Gd-based organic complexes), IONP present many advantages such as a better sensitivity, a poor toxicity, and the possibility to easily modify their surface to develop some properties as multimodality, modulable half-life or specificity. However, one must stress that these properties are related to IONP’s composition, shape and stability (physical and chemical). In that paper, we will introduce some concepts related to IONP’s physico-chemical properties, the synthetic ways to obtain such structures and we will finish with some concepts governing their stability and surface modification.
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References
Corot C, Robert P, Idee J-M, Port M (2006) Recent advances in iron oxide nanocrystal technology for medical imaging. Adv Drug Deliv Rev 58:1471–1504
Laurent S, Forge D, Port M et al (2008) Magnetic iron oxide nanoparticles: synthesis, stabilization, vectorization, physico-chemical characterizations and biological applications. Chem Rev 108:2064–2110
Yu M, Jeong Y, Park J et al (2008) Drug-loaded superparamagnetic iron oxide nanoparticles for combined cancer imaging and therapy in vivo. Angew Chem Int Ed Engl 47:5362–5365
Duguet E, Mornet S, Portier J (2004) Aqueous dispersions of magnetic iron oxide particles, surface modified by covalently grafting amino groups, useful as MRI contrast agents stable against agglomeration at neutral pH. French patent FR2855315
Bragg WH (1915) The structure of magnetite and the spinels. Nature 95:561
Fleet ME (1986) The structure of magnetite: symmetry of cubic spinels. J Sol State Chem 62(1):75–82
Evrim Umut. (2013). Surface modification of nanoparticles used in biomedical applications, modern surface engineering treatments. In Aliofkhazraei M (ed) ISBN: 978-953-51-1149-8, doi:10.5772/55746 (InTech)
Vestal CR, Zhang ZJ (2008) J Am Chem Soc 124:14312–14313
Gnanaprakash G, Panneerselvam G, Antony MP et al (2007) J Appl Phys 102:054305
Rondinone AJ, Samia ACS, Zhang ZJ (1999) J Phys Chem 103:6876–6880
Frenkel J, Doefman J (1930) Spontaneous and induced magnetisation in ferromagnetic bodies. Nature 126:274–275
Tartaj P, Serna CJ (2003) Synthesis of monodisperse superparamagnetic Fe/Silica nanospherical composites. J Am Chem Soc 125(51):15754–15755
Roch A, Gossuin Y, Muller RN, Gillis P (2005) Superparamagnetic colloid suspensions: water magnetic relaxation and clustering. J Magn Magn Mater 293(1):532–539
Dormann JL, Fiorani D, Tronc E (2007) Magnetic relaxation in fine-particle systems. Adv Chem Phys, pp 283–494
Laurent S, Forge D, Port M et al (2008) Magnetic iron oxide nanoparticles: synthesis, stabilization, vectorization, physicochemical characterizations, and biological applications. Chem Rev 108(6):2064–2110
Gossuin Y, Hocq A Gillis P et al (2009) Magnetic resonance relaxation properties of superparamagnetic particles. Wiley Interdisciplinary Rev Nanomed Nanobiotechnol 1(3):299–310
Pérez N, Guardia N, Roca P et al (2008) Surface anisotropy broadening of the energy barrier distribution in magnetic nanoparticles. Nanotechnology 19(47):475704
Roch A, Gillis P, Ouakssim A, Muller RN (1999) Proton magnetic relaxation in superparamagnetic aqueous colloids: a new tool for the investigation of ferrite crystal anisotropy. J Magn Magn Mater 201(13):77–79
Roch A, Muller RN, Gillis P (1999) Theory of proton relaxation induced by superparamagnetic particles. J Chem Phys 110(11):5403–5411
Freed JH (1978) Dynamic effects of pair correlation functions on spin relaxation by translational diffusion in liquids. II. Finite jumps and independent T1 processes. J Chem Phys 68(9):4034–4037
Ayant Y, Belorizky E, Aluzon J, Gallice J (1975) Calcul des densités spectrales résultant d’un mouvement aléatoire de translation en relaxation par interaction dipolaire magnétique dans les liquides. Journal de Physique France 36(10):991–1004
Gao J, Gu H, Xu B (2009) Multifunctional magnetic nanoparticles: design, synthesis, and biomedical applications. Acc Chem Res 42(8):1097–1107
Gupta AK, Gupta M (2005) Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications. Biomaterials 26(18):3995–4021
Reiss G, Hutten A (2005) Magnetic nanoparticles: applications beyond data storage. Nat Mater 4(10):725726
Carrillo AI, Serrano E, Luque R, García-Martínez J (2013) Microwave-assisted catalysis by iron oxide nanoparticles on MCM-41: effect of the support morphology. Appl Catal A Gen 453:383–390
Moodley P, Scheijen FJE, Niemantsverdriet JW, Thüne PC (2010) Iron oxide nanoparticles on flat oxidic surfaces—Introducing a new model catalyst for Fischer-Tropsch catalysis. Catal Today 154(1–2):142–148
Huang S-H, Juang R-S (2011) Biochemical and biomedical applications of multifunctional magnetic nanoparticles: a review. J Nanoparticle Res 13(10):4411–4430
Reddy LH, Arias JL, Nicolas J, Couvreur P (2012) Magnetic nanoparticles: design and characterization, toxicity and biocompatibility, pharmaceutical and biomedical applications. Chem Rev 112(11):5818–5878
Mahmoudi M, Sant S, Wang B, Laurent S, Sen T (2011) Superparamagnetic iron oxide nanoparticles (SPIONs): development, surface modification and applications in chemotherapy. Adv Drug Del Rev 63:24–46
Mersmann A (2001) Crystallization technology handbook, 2nd edn. Marcel Dekker Inc., New York, Basel
Massart R (1981) Preparation of aqueous magnetic liquids in alkaline and acidic media. Magnetics IEEE Trans 17(2):1247–1248
Sugimoto T, Matijević E (1980) Formation of uniform spherical magnetite particles by crystallization from ferrous hydroxide gels. J Coll Interface Sci 74(1):227–243
Babes L, Denizot B, Tanguy G (1999) Synthesis of iron oxide nanoparticles used as MRI contrast agents: a parametric study. J Coll Interface Sci 212(2):474–482
Pereira C, Pereira AM, Fernandes C et al (2012) Superparamagnetic MFe2O4 (M = Fe Co, Mn) nanoparticles: tuning the particle size and magnetic properties through a vovel one-step coprecipitation route. Chem Mater 24(8):1496–1504
Karaagac O, Kockar H (2012) Effect of synthesis parameters on the properties of superparamagnetic iron oxide nanoparticles. J Superconductivity Novel Magn 25(8):2777–2781
Gupta AK, Curtis ASG (2004) Lactoferrin and ceruloplasmin derivatized superparamagnetic iron oxide nanoparticles for targeting cell surface receptors. Biomaterials 25(15):3029–3040
Kim DK, Zhang Y, Voitet W et al (2001) Synthesis and characterization of surfactant-coated superparamagnetic monodispersed iron oxide nanoparticles. J Magn Magn Mater 225(1–2):30–36
Tartaj P, Morales MP, Veintemillas-Verdaguer S et al (2006) Handbook of magnetic materials. North-Holland, Elsevier, p 403
LaMer VK, Dinegar RH (1950) Theory, production and mechanism of formation of monodispersed hydrosols. J Am Chem Soc 72(11):4847–4854
Malik MA, Wani MY, Hashim MA (2011) Microemulsion method: a novel route to synthesize organic and inorganic nanomaterials. 1st nano update. Arabian J Chem 5(4):397–417
Massart R (1981) Preparation of aqueous magnetic liquids in alkaline and acidic media. IEEE Trans Magn 17:1247–1248
Massart R, Cabuil V (1987) Effect of some parameters on the formation of colloidal magnetite in alkaline medium: Yield and particle size control. J Chem Phys 84:967–973
Jolivet JP, Froidefond C, Pottier A et al (2004) Magnetic iron oxide nanoparticles: synthesis and applications. J Mater Chem 14(21):3281–3288
Jolivet JP, Vassiere L, Chaeneac C, Tronc E (1997) Mater Res Soc Symp Proc 432:145
Massart R, Roger J, Cabuil V (1995) New trends in chemistry of magnetic colloids: polar and non polar magnetic fluids, emulsions, capsules and vesicles. Braz J Phys 2:135–141
Jolivet JP, Belleville P, Tronc E, Livage J (1992) Influence of Fe(II) on the formation of the spinel iron-oxide in alkaline-medium. Clays Clay Miner 40:531–539
Qui X (2000) Synthesis and characterization of magnetic nano particles. Chin J Chem 18:834–837
Wu K, Kuo P, Yao Y, Tsai EH (2001) Magnetic and optical properties of Fe3O4 nanoparticle ferrofluids prepared by coprecipitation technique. IEEE Trans Magn 37:2651–2653
Tang J, Myers M, Bosnick KA, Brus LE (2003) Magnetite Fe3O4 nanocrystals: spectroscopic observations of aqueous oxidation kinetics. J Phys Chem B 107:7501–7506
Sato T, Haneda K, Seki M, Iijima T (1990) Morphology and magnetic properties of ultrafine ZnFe2O4 particles. Appl Phys A 50:13–16
Alves CR, Aquino R, Sousa MH et al (2004) Low temperature experimental investigation of finite-size and surface effects in CuFe2O4 nanoparticles of ferrofluids. J Metastable Nanocryst Mater 20:694–699
Jolivet JP, Chaneac C, Tronc E (2004) Iron oxide chemistry. From molecular clusters to extended solid networks. Chem Commun 5:481–483
Mao Z, Kang E, Wang S et al (2006) Synthesis of magnetite octahedrons from iron powders through a mild hydrothermal method. Mater Res Bull 41:2226–2231
Zhu H, Yang D, Zhu L (2007) Hydrothermal growth and characterization of magnetite (Fe3O4) thin films. Surf Coat Technol 201:5870–5874
Willard MA, Kurihara LK, Carpenter EE et al (2004) Encyclopedia of nanoscience and nanotechnology. American Scientific Publishers, Stevenson Ranch, p 815252
Chen D, Xu R (1998) Hydrothermal synthesis and characterization of nanocrystalline Fe3O4 powders. Mater Res Bull 33:1015–1021
Zheng YH, Cheng Y, Bao F, Wang YS (2006) Synthesis and magnetic properties of Fe3O4 nanoparticles. Mater Res Bull 41(3):525–529
Hyeon T, Lee SS, Park J, Chung Y, Na HB (2001) Synthesis of highly crystalline and monodisperse maghemite nanocrystallites without a size-selection process. J Am Chem Soc 123:12798–12801
Sun S, Zeng H, Robinson DB et al (2003) Monodisperse MFe2O4 (M = Fe Co, Mn) nanoparticles. J Am Chem Soc 126:179–273
Woo K, Hong J, Ahn JP (2005) Synthesis and surface modification of hydrophobic magnetite to processible magnetite@silica-propylamine. J Magn Magn Mater 293:177–181
Park J, Lee E, Hwang NM et al (2005) One-nanometer-scale size-controlled synthesis of monodisperse magnetic iron oxide nanoparticles. Angew Chem Inter Ed 44(19):2873–2877
Li Z, Sun Q, Gao M (2004) Preparation of water-soluble magnetite nanocrystals from hydrated ferric salts in 2-pyrrolidone: mechanism leading to Fe3O4. Angew Chem Inter Ed 44(1):123–126
Wan J, Cai W, Feng J et al (2007) In situ decoration of carbon nanotubes with nearly monodisperse magnetite nanoparticles in liquid polyols. J Mater Chem 17:1188–1192
Jun YW, Huh YM, Choi JS et al (2005) Nanoscale size effect of magnetic nanocrystals and their utilization for cancer diagnosis via magnetic resonance imaging. J Am Chem Soc 127(16):5732–5733
Amara D, Felner I, Nowik I, Margel S (2009) Synthesis and characterization of Fe and FeO4 nanoparticles by thermal decomposition of triiron dodecacarbonyl. Coll Surf A Physicochem Eng Aspects 339:106–110
Caruntu D, Remond Y, Chou NH, Jun MJ (2002) Reactivity of 3d transition metal cations in diethylene glycol solutions. Synthesis of transition metal ferrites with the structure of discrete nanoparticles complexed with long-chain carboxylate anions. Inorg Chem 41:6137–6146
Caruntu D, Caruntu G, Yuxi C et al (2004) Synthesis of variable-sized nanocrystals of Fe3O4 with high surface reactivity. Chem Mater 16:5527–5534
Li Z, Chen H, Bao H, Gao M (2004) One-pot reaction to synthesize water-soluble magnetite nanocrystals. Chem Mater 16:1391–1393
Li Z, Wei L, Gao M, Lei H (2005) One-pot reaction to synthesize biocompatible magnetite nanoparticles. Adv Mater 17:1001–1005
Hu F, Wei L, Zhou Z, Ran Y, Li Z, Gao M (2006) Preparation of biocompatible magnetite nanocrystals for in vivo magnetic resonance detection of cancer. Adv Mater 18:2552–2556
Adireddy S, Lin C, Palshin V (2009) Size-controlled synthesis of quasi-monodisperse transition-metal ferrite nanocrystals in fatty alcohol solutions. J Phys Chem C 113:20800–20811
Jun Y-W, Lee J-H, Cheon J (2008) Chemical design of nanoparticle probes for high-performance magnetic resonance imaging. Angew Chem Inter Ed 47:5122–5135
Gupta AK, Gupta M (2005) Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications. Biomaterials 26:3995–4021
Lam UT, Mammucari R, Suzuki K, Foster NR (2008) Processing of iron oxide nanoparticles by supercritical fluids. Ind Eng Chem Res 47(3):599–614
Tavakoli A, Sohrabi M, Kargari A (2007) A review of methods for synthesis of nanostructured metals with emphasis on iron compounds. Chem Papers 61(3):151–170
Del Monte F, Morales MP, Levy D et al (1997) Formation of γ-Fe2O3 isolated nanoparticles in a silica matrix. Langmuir 13:3627–3634
Niznansky D, Rehspringer JL, Drillon M (1994) Preparation of magnetic nanoparticles (gamma-Fe2O3) in the silica matrix. IEEE Trans Magn 30:821–823
Bentivegna F, Ferré J, Nyvlt M et al (1998) Magnetically textured y-Fe2O3 nanoparticles in a silica gel matrix: structural and magnetic properties. J Appl Phys 83:7776–7786
Pileni MP (1993) Reverse micelles as microreactors. J Phys Chem 97(27):6961–6973
Lawrence MJ, Rees GD (2000) Microemulsion-based media as novel drug delivery systems. Adv Drug Del Rev 45(1):89–121
Fendler JH (1987) Atomic and molecular clusters in membrane mimetic chemistry. Chem Rev 87:877–899
Sugimoto T (1987) Preparation of monodispersed colloidal particles. Adv Coll Interface Sci 28:65–108
Vidal-Vidal J, Rivas J, López-Quintela MA (2006) Synthesis of monodisperse maghemite nanoparticles by the microemulsion method. Colloid Surf A, pp 44–51
Jézéquel D, Guenot J, Jouini N, Fiévet F (1995) Submicrometer zinc-oxide nanoparticles—Elaboration in polyol medium and morphological characteristics. J Mater Res 10:77–83
Fievet F, Fievet-Vincent F, Lagier JP et al (1992) Preparation de particules monodisperses de cobalt et de nickel de taille micronique et submicronique. J Phys IV 02(C3):91
Tzitzios VK, Petridis D, Zafiropoulou I et al (2005) Synthesis and characterization of L10 FePt nanoparticles from Pt–Fe3O4 core-shell nanoparticle. J Magn Magn Mater 294(2):95–98
Joseyphus RJ, Kodama D, Matsumoto T et al (2007) Role of polyol in the synthesis of Fe particles. J Magn Magn Mater 310(2):2393–2395
Cai W, Wan J (2007) Facile synthesis of superparamagnetic magnetite nanoparticles in liquid polyols. J Coll Interface Sci 305:366–370
Pascal C, Pascal JL, Favier F et al (1999) Electrochemical synthesis for the control of γ-Fe2O3 nanoparticle size. Morphology, microstructure, and magnetic behavior. Chem Mater 11:141–147
Veintemillas-Vendaguer S, Morales MP, Bomati-Miguel O et al (2004) Colloidal dispersions of maghemite nanoparticles produced by laser pyrolysis with application as NMR contrast agents. J Phys 37:2054–2059
Alexandrescu R, Morjan I, Voicu I et al (2005) Combining resonant/non-resonant processes: nanometer-scale iron-based material preparation via CO2 laser pyrolysis. Appl Surf Sci 248(1–4):138–146
Bautista MC, Bomati-Miguel O, Moraleset MP et al (2005) Surface characterisation of dextran-coated iron oxide nanoparticles prepared by laser pyrolysis and coprecipitation. J Magn Magn Mater 293:20–27
Puntes VF, Krishnan KM, Alivisatos AP (2002) Synthesis of colloidal cobalt nanoparticles with controlled size and shapes. Top Catal 19:145–148
Rotstein HG, Tannenbaum R (2002) Cluster coagulation and growth limited by surface interactions with polymers. J Phys Chem B 106:146–151
Mukh-Qasem RA, Gedanken A (2005) Sonochemical synthesis of stable hydrosol of Fe3O4 nanoparticles. J Coll Interface Sci 284(2):489–494
Kim EH, Lee HS, Kwak BK, Kim BK (2005) Synthesis of ferrofluid with magnetic nanoparticles by sonochemical method for MRI contrast agent. J Magn Magn Mater 289:328–330
Cosgrove T (2010). In: Cosgrove T (ed) Colloid science: principles, methods and applications. Wiley, USA
Derjaguin B (1940) On the repulsive forces between charged colloid particles and on the theory of slow coagulation and stability of lyophobe sols. Trans Faraday Soc 35:203–215
Derjaguin B, Landau L (1993) Theory of the stability of strongly charged lyophobic sols and of the adhesion of strongly charged particles in solutions of electrolytes. Progr Surf Sci 43(1–4):30–59
Derjaguin BV (1993) Some new aspects of and conclusions on theory of stability of colloids and their experimental verification. Progr Surf Sci 43(1–4):115–121
Derjaguin BV, Voropayeva TN, Kabanov BN, Titiyevskaya AS (1993) Surface forces and the stability of colloids and disperse systems. Progr Surf Sci 43(1–4):83–105
Verwey EJW (1935) The electrical double layer and the stability of lyophobic colloids. Chem Rev 16(3):363415
Verwey EJW (1947) Theory of the stability of lyophobic colloids. J Phys Coll Chem 51(3):631–636
Verwe EJW, Overbeek JTG (1955) Theory of the stability of lyophobic colloids. J Coll Sci 10(2):224–225
Wu I, Risalvato FG, Ke F-S et al (2012) Electrochemical reduction of carbon dioxide I. Effects of the electrolyte on the selectivity and activity with Sn electrode. J. Electrochem Soc 159(7):F353–F359
Leong YK, Ong BC (2003) Critical zeta potential and the Hamaker constant of oxides in water. Powder Technol 134(3):249–254
Hogg R, Healy TW, Fuerstenau DW (1966) Mutual coagulation of colloidal dispersions. Trans Faraday Soc 62:1638–1651
Boström M, Williams D, Ninham B (2001) Specific ion effects: Why DLVO theory fails for biology and colloid systems. Phys Rev Lett 87(16):168103
Parks GA, De Bruyn PL (1962) The zero point of charge of oxide 1. J Phys Chem 66(6):967973
Haines RI, Owen DG, Vandergraaf TT (1987) Technetium-iron oxide reactions under anaerobic conditions: a Fourier transform infrared, FTIR study. Nucl J Can 1(1):32–37
Milonjić SK, Kopečni MM, Ilić ZE (1983) The point of zero charge and adsorption properties of natural magnetite. J Radioanal Chem 78(1):15–24
Tewari PH, McLean AW (1972) Temperature dependence of point of zero charge of alumina and magnetite. J Coll Inter Sci 40(2):267–272
Jolivet JP, Tronc E, Chanéac C (2000) Synthesis of iron oxide- and metal-based nanomaterials. Eur Phys J App Phys 10:167–172
Anandarajah A, Chen J (1994) Double-layer repulsive force between two inclined platy particles according to the Gouy-Chapman theory. J Coll Interface Sci 168(1):111–117
Baldelli S (2008) Surface structure at the ionic liquid–electrified metal interface. Acc Chem Res 41(3):421–431
Bohinc K, Shrestha A, Brumen M, May S (2012) Poisson-Helmholtz-Boltzmann model of the electric double layer: analysis of monovalent ionic mixtures. Phys Rev E 85(3):031130
Hu Y (1998) Effects of an inner Helmholtz layer on the dielectric dispersion of colloidal suspensions. Langmuir 14(2):271–276
Yates DE, Levine S, Healy TW (1974) Site-binding model of the electrical double layer at the oxide/water interface. J Chem Soc Faraday Trans 1 Phys Chem Cond Phases 70:18071818
Usui S (2004) Interaction between dissimilar double layers with like signs under charge regulation on the basis of the Gouy–Chapman–Stern–Grahame model. J Colloid Interface Sci 280(1):113–119
Devanathan MAV, Tilak BVKSRA (1965) The structure of the electrical double layer at the metal-solution interface. Chem Rev 65(6):635–684
Kuchibhatla S, Karakoti AS, Sea S (2005) Colloidal stability by surface modification. JOM 57(12):52–56
Napper DH (1970) Colloid stability. Ind Eng Chem Prod Res Dev 9(4):467477
Napper DH, Netschey A (1971) Studies of the steric stabilization of colloidal particles. J Coll Interface Sci 37(3):528–535
Napper DH (1977) Steric stabilization. J Coll Interface Sci 58(2):390–407
Roca AG, Costo R, Rebolledo AF et al (2009) Progress in the preparation of magnetic nanoparticles for applications in biomedicine. J Phys D Appl Phys 42(22):224002
Lee H, Yu MK, Park S, Moon S et al (2007) Thermally cross-linked superparamagnetic iron oxide nanoparticles: synthesis and application as a dual imaging probe for cancer in vivo. J Am Chem Soc 129(42):12739–12745
De Palma R, Peeters S, Van Bael MJ et al (2007) Silane ligand exchange to make hydrophobic superparamagnetic nanoparticles water-dispersible. Chem Mater 19(7):1821–1831
Kohler N, Fryxell GE, Zhang M (2004) A bifunctional poly(ethylene glycol) silane immobilized on metallic oxidebased nanoparticles for conjugation with cell targeting agents. J Am Chem Soc 126(23):72067211
Larsen EKU, Nielsen T, Wittenborn T et al (2009) Size-dependent accumulation of PEGylated silanecoated magnetic iron oxide nanoparticles in murine tumors. ACS Nano 3(7):1947–1951
Ninjbadgar T, Brougham DF (2011) Epoxy ring opening phase transfer as a general route to water dispersible superparamagnetic Fe3O4 nanoparticles and their application as positive MRI contrast agents. Adv Funct Mater 21(24):4769–4775
Pinho SLC, Laurent S, Rocha J et al (2011) Relaxometric studies of γ-Fe2O3@SiO2 core shell nanoparticles: when the coating matters. J Phys Chem C 116(3):2285–2291
Carpenter EE, Sangregorio C, O’Connor CJ (1999) Effects of shell thickness on blocking temperature of nanocomposites of metal particles with gold shells. IEEE Trans Magn 35(5):3496–3498
Maleki H, Simchi A, Imani M, Costa BFO (2012) Size-controlled synthesis of superparamagnetic iron oxide nanoparticles and their surface coating by gold for biomedical applications. J Magn Magn Mater 324(23):3997–4005
Boyer C, Whittaker MR, Bulmus V et al (2010) The design and utility of polymer-stabilized iron-oxide nanoparticles for nanomedicine applications. NPG Asia Mater 2:23–30
Forge D, Roch A, Laurent S et al (2008) Optimization of the synthesis of superparamagnetic contrast agents by the design of experiments method. J Phys Chem C 112(49):19178–19185
Dias AMGC, Hussain A, Marcos AS, Roque ACA (2011) A biotechnological perspective on the application of iron oxide magnetic colloids modified with polysaccharides. Biotechn Adv 29(1):142–155
Chanana M, Mao WD (2009) Using polymers to make up magnetic nanoparticles for biomedicine. J Biomed Nanotechnol 5(6):652–668
Yun Tack L, Kyoungja W, Kyu-Sil C (2008) Preparation of water-dispersible and biocompatible iron oxide nanoparticles for MRI agent. IEEE Trans Nanotechnol 7(2):111–114
Bautista CM, Bomati-Miguel O, Del Puerto MM et al (2005) Surface characterisation of dextrancoated iron oxide nanoparticles prepared by laser pyrolysis and coprecipitation. J Magn Magn Mater 293(1):20–27
Easo SL, Mohanan PV (2013) Dextran stabilized iron oxide nanoparticles: synthesis, characterization and in vitro studies. Carbohydr Polym 92(1):726–732
Rosen JE, Chan L, Shieh D-B, Gu FX (2012) Iron oxide nanoparticles for targeted cancer imaging and diagnostics. Nanomed Nanotechnol Biol Med 8(3):275–290
Weissleder R, Hahn PF, Stark DD et al (1987) MR imaging of splenic metastases: ferrite-enhanced detection in rats. Am J Roentgenol 149(4):723–726
Weissleder R, Stark DD, Engelstad BL et al (1989) Superparamagnetic iron oxide: pharmacokinetics and toxicity. Am J Roentgenol 152(1):167–173
Corot C, Robert P, Idée J-M, Port M (2006) Recent advances in iron oxide nanocrystal technology for medical imaging. Adv Drug Del Rev 58(14):1471–1504
Josephson L, Tung C-H, Moore A, Weissleder R (1999) High-efficiency intracellular magnetic labeling with novel superparamagnetic-Tat peptide conjugates. Bioconjugate Chem 10(2):186–191
McCarthy JR, Weissleder R (2008) Multifunctional magnetic nanoparticles for targeted imaging and therapy. Adv Drug Del Rev 60(11):1241–1251
Deng J, He J, Zheng J-S et al (2012) Preparation and application of amino- and dextran-modified superparamagnetic iron oxide nanoparticles. Part Sci Technol 31(3):241–247
Duguet E, Vasseur S, Mornet S et al (2006) Towards a versatile platform based on magnetic nanoparticles for in vivo applications. Bull Mater Sci 29(6):581–586
Mornet S, Portier J, Duguet E (2005) A method for synthesis and functionalization of ultrasmall superparamagnetic covalent carriers based on maghemite and dextran. J Magn Magn Mater 293(1):127–134
Chaleawlert-Umpon S, Mayen V, Manotham K, Pimpha N (2010) Preparation of iron oxide-entrapped chitosan nanoparticles for stem cell labeling. J Biomater Sci Polym Ed 21(11):1515–1532
Szpak A, Kania G, Skórka T et al (2012) Stable aqueous dispersion of superparamagnetic iron oxide nanoparticles protected by charged chitosan derivatives. J Nanoparticle Res 15(1):1–11
Tsai Z-T, Wang J-F, Kuo H-Y et al (2010) In situ preparation of high relaxivity iron oxide nanoparticles by coating with chitosan: a potential MRI contrast agent useful for cell tracking. J Magn Magn Mater 322(2):208–213
Gaihre B, Khil MS, Lee DR, Kim HY (2009) Gelatin-coated magnetic iron oxide nanoparticles as carrier system: drug loading and in vitro drug release study. Int J Pharm 365(1–2):180–189
Ma H-L, Qi X-R, Maitani Y, Nagai T (2007) Preparation and characterization of superparamagnetic iron oxide nanoparticles stabilized by alginate. Int J Pharm 333(1–2):177–186
Gao F, Cai Y, Zhou J et al (2010) Pullulan acetate coated magnetite nanoparticles for hyper-thermia: preparation, characterization and in vitro experiments. Nano Res 3(1):23–31
Cheng F-Y, Wang SP-H, Su C-H et al (2008) Stabilizer-free poly(lactide-co-glycolide) nanoparticles for multimodal biomedical probes. Biomaterials 29(13):2104–2112
Lee S-J, Jeong J-R, Shin S-C et al (2004) Nanoparticles of magnetic ferric oxides encapsulated with poly(d,l latide-co-glycolide) and their applications to magnetic resonance imaging contrast agent. J Magn Magn Mater 272–276:2432–2433 (Part 3(0))
Mahmoudi M, Simchi A, Imani M et al (2008) Optimal design and characterization of superparamagnetic iron oxide nanoparticles coated with polyvinyl alcohol for targeted delivery and imaging. J Phys Chem B 112(46):14470–14481
Zhou L, He B, Zhang F (2011) Facile one-pot synthesis of iron oxide nanoparticles cross-linked magnetic poly(vinyl alcohol) gel beads for drug delivery. ACS Appl Mater Interfaces 4(1):192–199
Garcia I, Tercjak A, Zafeiropoulos NE et al (2007) Generation of core/shell iron oxide magnetic nanoparticles with polystyrene brushes by atom transfer radical polymerization. J Polym Sci Part A Polym Chem 45(20):4744–4750
Wang Y, Teng X, Wang J-S, Yang H (2003) Solvent-free atom transfer radical polymerization in the synthesis of Fe2O3@polystyrene core–shell nanoparticles. Nano Lett 3(6):789–793
Bae S-J, Park J-A, Lee J-J et al (2009) Ultrasmall iron oxide nanoparticles: synthesis, physicochemical, and magnetic properties. Curr Appl Phys 9(1):19–21
Lee HY, Lim NH, Seo JA et al (2006) Preparation and magnetic resonance imaging effect of polyvinylpyrrolidone-coated iron oxide nanoparticles. J Biomed Mater Res Part B Appl Biomater 79B(1):142–150
Xu Y-Y, Zhou M, Geng H-J et al (2012) A simplified method for synthesis of Fe3O4@PAA nanoparticles and its application for the removal of basic dyes. Appl Surf Sci 258(8):3897–3902
Masotti A, Pitta A, Ortaggi G et al (2009) Synthesis and characterization of polyethylenimine-based iron oxide composites as novel contrast agents for MRI. Magn Reson Mater Phys Biol Med 22(2):77–87
Wang Z, Liu G, Sun J et al (2012) N-alkyl-polyethylenimine stabilized iron oxide nanoparticles as MRI visible transfection agents. J Nanosci Nanotechnol 12(2):879–886
Ge Y, Zhang S, He S et al (2009) Fabrication and characterization of chitosan-poly(acrylic acid) magnetic nanospheres. J Nanosci Nanotechnol 9(2):1287–1290
Fauconnier N, Pons JN, Roger J, Bee A (1997) Thiolation of maghemite nanoparticles by dimercaptosuccinic acid. J Coll Interface Sci 194(2):427–433
Lattuad M, Hatton TA (2006) Functionalization of monodisperse magnetic nanoparticles. Langmuir 23(4):21582168
Maurizi L, Bisht H, Bouyer F, Millot N (2009) Easy route to functionalize iron oxide nanoparticles via long-term stable thiol groups. Langmuir 25(16):8857–8859
Miguel-Sancho N, Bomatí-Miguel O, Colom G et al (2011) Development of stable, water-dispersible, and biofunctionalizable superparamagnetic iron oxide nanoparticles. Chem Mater 23(11):2795–2802
Răcuciu M, Creangă DE, Airinei A (2006) Citric-acid-coated magnetite nanoparticles for biological applications. Eur Phys J 21(2):117–121
Benbenishty-Shamir H, Gilert R, Gotman I et al (2011) Phosphonate-anchored monolayers for antibody binding to magnetic nanoparticles. Langmuir 27(19):12082–12089
Daou TJ, Begin-Colin S, Grenèche JM et al (2007) Phosphate adsorption properties of magnetite-based nanoparticles. Chem Mater 19(18):4494–4505
Daou TJ, Grenèche JM, Pourroy G et al (2008) Coupling agent effect on magnetic properties of functionalized magnetite-based nanoparticles. Chem Mater 20(18):5869–5875
Guerrero G, Mutin PH, Vioux A (2001) Anchoring of phosphonate and phosphinate coupling molecules on titania particles. Chem Mater 13(11):4367–4373
Karimi A, Denizot B, Passirani C et al (2013) In vitro and in vivo evaluation of superparamagnetic iron oxide nanoparticles coated by bisphosphonates: the effects of electrical charge and molecule length. Eur J Pharm Sci 49(2):101–108
Lalatonne Y, Paris C, Serfaty JM et al (2008) Bis-phosphonates-ultra small superparamagnetic iron oxide nanoparticles: a platform towards diagnosis and therapy. Chem Commun 22:2553–2555
Portet D, Denizot B, Rump E et al (2001) Comparative biodistribution of thin-coated iron oxide nanoparticles TCION: effect of different bisphosphonate coatings. Drug Dev Res 54(4):173–181
Park J-A, Lee J-J, Kim I-S et al (2008) Magnetic and MR relaxation properties of avidin–biotin conjugated superparamagnetic nanoparticles. Coll and Surfaces A Physicochem Eng Aspects 313–314:288–291
Quan Q, Xie J, Gao H et al (2011) HSA coated iron oxide nanoparticles as drug delivery vehicles for cancer therapy. Mol Pharm 8(5):1669–1676
Xie J, Wang J, Niu G et al (2010) Human serum albumin coated iron oxide nanoparticles for efficient cell labeling. Chem Commun 46(3):433–435
Gonzales M, Krishnan KM (2007) Phase transfer of highly monodisperse iron oxide nanocrystals with Pluronic F127 for biomedical applications. J Magn Magn Mater 311(1):59–62
Jain TK, Foy SP, Erokwu B et al (2009) Magnetic resonance imaging of multifunctional pluronic stabilized iron-oxide nanoparticles in tumor-bearing mice. Biomaterials 30(35):6748–6756
Jain TK, Morales MA, Sahoo SK et al (2005) Iron oxide nanoparticles for sustained delivery of anticancer agents. Mol Pharm 2(3):194–205
Morales MA, Jain TK, Labhasetwar V, Leslie-Pelecky DL (2005) Magnetic studies of iron oxide nanoparticles coated with oleic acid and Pluronic block copolymer. J Appl Phys 97(10):10Q903–10Q905
Qin J, Asempah I, Laurent S et al (2009) Injectable superparamagnetic ferrogels for controlled release of hydrophobic drugs. Adv Mater 21(13):1354–1357
Muir BW, Moffat BA, Harbour P et al (2009) Combinatorial discovery of novel amphiphilic polymers for the phase transfer of magnetic nanoparticles. J Phys Chem C 113(38):16615–16624
Park J, Yu MK, Jeong YY et al (2009) Antibiofouling amphiphilic polymer-coated superparamagnetic iron oxide nanoparticles: synthesis, characterization, and use in cancer imaging in vivo. J Mater Chem 19(35):6412–6417
Pimpha N, Chaleawlert-Umpon S, Sunintaboon P (2012) Core/shell polymethyl methacrylate/polyethyleneimine particles incorporating large amounts of iron oxide nanoparticles prepared by emulsifier-free emulsion polymerization. Polymer 53(10):2015–2022
Prakash A, Zhu H, Jones CJ et al (2009) Bilayers as phase transfer agents for nanocrystals prepared in nonpolar solvents. ACS Nano 3(8):2139–2146
William WY, Emmanuel C, Christie MS et al (2006) Aqueous dispersion of monodisperse magnetic iron oxide nanocrystals through phase transfer. Nanotechnology 17(17):4483–4487
Kim J, Lee JE, Lee J et al (2005) Magnetic fluorescent delivery vehicle using uniform mesoporous silica spheres embedded with monodisperse magnetic and semiconductor nanocrystals. J Am Chem Soc 128(3):688–689
Wang X, Chen Y (2008) A new two-phase system for the preparation of nearly monodisperse silver nanoparticles. Mater Lett 62(28):4366–4368
Shen L, Laibinis PE, Hatton TA (1998) Bilayer surfactant stabilized magnetic fluids: synthesis and interactions at interfaces. Langmuir 15(2):447–453
Wooding A, Kilner M, Lambrick DB (1991) Studies of the double surfactant layer stabilization of water-based magnetic fluids. J Coll Interface Sci 144(1):236–242
Deng M, Tu N, Bai F, Wang L (2012) Surface functionalization of hydrophobic nanocrystals with one particle per micelle for bioapplications. Chem Mater 24(13):2592–2597
Thanh NTK, Green LAW (2010) Functionalisation of nanoparticles for biomedical applications. Nano Today 5(3):213–230
Ingram DR, Kotsmar C, Yoon KY et al (2010) Superparamagnetic nanoclusters coated with oleic acid bilayers for stabilization of emulsions of water and oil at low concentration. J Coll Interface Sci 351(1):225–232
Li L, Mak KY, Leung CW et al (2012) Synthesis and characterization of self-assembled monolayer and bilayer carboxyl-group functionalized magnetic nanoparticles. IEEE Trans Magn 48(11):3299–3302
Bittova B, Poltierova-Vejpravova J, Roca AG et al (2010) Effects of coating on magnetic properties in iron oxide nanoparticles. J Phys Conf Ser 200(7):072012
Haddad PS, Martins TM, D’Souza-Li L et al (2008) Structural and morphological investigation of magnetic nanoparticles based on iron oxides for biomedical applications. Mater Sci Eng C 28(4):489–494
Roca AG, Veintemillas-Verdaguer S, Port M et al (2009) Effect of nanoparticle and aggregate size on the relaxometric properties of MR contrast agents based on high quality magnetite nanoparticles. J Phys Chem B 113(19):7033–7039
Salas G, Casado C, Teran FJ et al (2012) Controlled synthesis of uniform magnetite nanocrystals with high-quality properties for biomedical applications. J Mater Chem 22(39):21065–21075
Yihang W, Mengjie S, Zhuang X et al (2011) Ultra-small particles of iron oxide as peroxidase for immunohistochemical detection. Nanotechnology 22(22):225703
Guardia P, Pérez N, Labarta A, Batlle X (2009) Controlled synthesis of iron oxide nanoparticles over a wide size range. Langmuir 26(8):5843–5847
Salgueiriño-Maceira V, Liz-Marzán LM, Farle M (2004) Water-based ferrofluids from FexPt1-x nanoparticles synthesized in organic media. Langmuir 20(16):6946–6950
Taboada E, Rodríguez E, Roig A et al (2007) Relaxometric and magnetic characterization of ultrasmall iron oxide nanoparticles with high magnetization. Evaluation as potential T1 magnetic resonance imaging contrast agents for molecular imaging. Langmuir 23(8):4583–4588
Smolensky ED, Park H-YE, Berquó TS, Pierre VC (2011) Surface functionalization of magnetic iron oxide nanoparticles for MRI applications—Effect of anchoring group and ligand exchange protocol. Contrast Media Mol Imaging 6(4):189–199
Na HB, Palui G, Rosenberg JT et al (2011) Multidentate catechol-based polyethylene glycol oligomers provide enhanced stability and biocompatibility to iron oxide nanoparticles. ACS Nano 6(1):389–399
Peng S, Wang C, Xie J, Sun S (2006) Synthesis and stabilization of monodisperse Fe nanoparticles. J Am Chem Soc 128(33):10676–10677
Xie J, Xu C, Kohler N et al (2007) Controlled PEGylation of monodisperse Fe3O4 nanoparticles for reduced non-specific uptake by macrophage cells. Adv Mater 19(20):3163–3166
Huang G, Zhang C, Li S et al (2009) A novel strategy for surface modification of superparamagnetic iron oxide nanoparticles for lung cancer imaging. J Mater Chem 19(35):6367–6372
Kyoungja W, Hong J (2005) Surface modification of hydrophobic iron oxide nanoparticles for clinical applications. IEEE Trans Magn 41(10):4137–4139
Fang C, Bhattarai N, Sun C, Zhang M (2009) Functionalized nanoparticles with long-term stability in biological media. Small 5(14):1637–1641
Ge J, Hu Y, Biasini M et al (2007) One-step synthesis of highly water-soluble magnetite colloidal nanocrystals. Chem A Eur J 13(25):7153–7161
Lattuada M, Hatton TA (2006) Functionalization of monodisperse magnetic nanoparticles. Langmuir 23(4):2158–2168
Zhang T, Ge J, Hu Y et al (2007) A general approach for transferring hydrophobic nanocrystals into water. Nano Lett 7(10):3203–3207
Tartaj P, González-Carreño T, Serna CJ (2001) Single-step nanoengineering of silica coated maghemite hollow spheres with tunable magnetic properties. Adv Mater 13(21):1620–1624
Huang X, Schmucker A, Dyke J et al (2009) Magnetic nanoparticles with functional silanes: evolution of well-defined shells from anhydride containing silane. J Mater Chem 19(24):4231–4239
Bloemen M, Brullot W, Luong T et al (2012) Improved functionalization of oleic acid-coated iron oxide nanoparticles for biomedical applications. J Nanoparticle Res 14(9):1–10
Darbandi M, Lu W, Fang J, Nann T (2006) Silica encapsulation of hydrophobically ligated PbSe nanocrystals. Langmuir 22(9):4371–4375
Darbandi M, Urban G, Krüger M (2010) A facile synthesis method to silica coated CdSe/ZnS nanocomposites with tuneable size and optical properties. J Coll Interface Sci 351(1):30–34
Masih D, Frank S, Joachim L et al (2012) Nanoscale size effect on surface spin canting in iron oxide nanoparticles synthesized by the microemulsion method. J Phys D Appl Phys 45(19):195001
Selvan ST, Tan TT, Ying JY (2005) Robust, non-cytotoxic, silica-coated CdSe quantum dots with efficient photoluminescence. Adv Mater 17(13):1620–1625
Narita A, Naka K, Chujo Y (2009) Facile control of silica shell layer thickness on hydrophilic iron oxide nanoparticles via reverse micelle method. Coll Surf A Physicochem Eng Aspects 336(1–3):4656
Ding H, Zhang Y, Wang S et al (2012) Fe3O4@SiO2 core/shell nanoparticles: the silica coating regulations with a single-core for different core sizes and shell thicknesses. Chem Mater 24(23):4572–4580
Kim J, Kim HS, Lee N et al (2008) Multifunctional uniform nanoparticles composed of a magnetite nanocrystal core and a mesoporous silica shell for magnetic resonance and fluorescence imaging and for drug delivery. Angew Chem 120(44):8566–8569
Shen R, Camargo PHC, Xia Y, Yang H (2008) Silane-based poly(ethylene glycol) as a primer for surface modification of nonhydrolytically synthesized nanoparticles using the Stöber method. Langmuir 24(19):11189–11195
Dai Q, Lam M, Swanson S et al (2010) Monodisperse cobalt ferrite nanomagnets with uniform silica coatings. Langmuir 26(22):17546–17551
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Laurent, S. et al. (2017). Superparamagnetic Iron Oxide Nanoparticles. In: MRI Contrast Agents. SpringerBriefs in Applied Sciences and Technology(). Springer, Singapore. https://doi.org/10.1007/978-981-10-2529-7_5
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