Abstract
This study investigated the associations between dietary history of past taurine intake and cognitive function in the elderly. Subjects of this study were 40 elderly persons with dementia (men 14, women 26) and 37 normal elderly persons (men 5, women 32). Data were collected using questionnaires by investigator-based interview to the elderly and family caregivers. We examined their general characteristics, anthropometric data, cognitive function, and taurine index. Cognitive function was measured using MMSE-DS and higher score means better cognitive function. As dietary history of past taurine intake, taurine index was evaluated by scoring the intake frequency of 41 kinds of taurine-containing foods. Part correlation analysis (sex, age, and school educational period correction) was used to analyze associations between taurine index and cognitive function. The analysis of all data was carried out by the SPSS 20.0 program for windows. The age, height, weight, and BMI of elderly with dementia showed no statistical significance compared to normal elderly. The elderly with dementia had significantly higher school education period (7.4 years) than the normal elderly (4.8 years) (p < 0.01). Nevertheless, the average total score of cognitive function (MMSE-DS) of the elderly with dementia (18.1 points) was significantly lower than score of the normal elderly (21.7 points) (p < 0.05). The average taurine index of the elderly with dementia (104.7 points) was significantly lower than average taurine index of the normal elderly (123.7 points) (p < 0.01). There were positive correlations between total taurine index and total score of cognitive function in all the elderly subjects (p < 0.05). In particular, as taurine index was higher, there were significantly higher scores of cognitive function such as ‘time orientation’ and ‘judgement and abstract thinking’ (p < 0.01). In conclusion, these results suggest that past taurine intake may have a positive effect on present cognitive function in the elderly.
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Abbreviations
- BMI:
-
Body Mass Index
- MMSE-DS:
-
Mini-Mental State Examination-Dementia Screening
References
Barberger-Gateau P, Letenneur L, Deschamps V, Pérès K, Dartigues JF, Renaud S (2002) Fish, meat, and risk of dementia: cohort study. BMJ 325:932–933
Barberger-Gateau P, Raffaitin C, Letenneur L, Berr C, Tzourio C, Dartigues JF, Alpérovitch A (2007) Dietary patterns and risk of dementia. Neurology 69(13):1921–1930
Braak H, Braak E (1991) Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 82:239–259
Central dementia center [Internet] 2016. http://www.nid.or.kr/dementia_center/statistics/statistics.asp
Cooper JK (2014) Nutrition and the brain: what advice should we give? Neurobiol Aging 35:S79–S83
Chen WQ, Jin H, Nguyen M, Carr J, Lee YJ, Hsu CC, Faiman MD, Schloss JV, Wu JY (2001) Role of taurine in regulation of intracellular calcium level and neuroprotective function in cultured neurons. J Neurosci Res 66(4):612–619
Dangour AD, Whitehouse PJ, Rafferty K, Mitchell SA, Smith L, Hawkesworth S, Vellas B (2010) B-vitamins and fatty acids in the prevention and treatment of Alzheimer’s disease and dementia: a systematic review. J Alzheimers Dis 22(1):205–224
Duthie SJ, Whalley LJ, Collins AR, Leaper S, Berger K, Deary IJ (2002) Homocysteine, B vitamin status, and cognitive function in the elderly. Am J Clin Nutr 75(5):908–913
Han JW, Kim TH, Jhoo JH, Park JH, Kim JL, Ryu SH, Moon SW, Choo IH, Lee DW, Yoon JC, Do YJ, Lee SB, Kim MD, Kim KW (2010) A normative study of the mini-mental state examination for dementia screening (MMSE-DS) and its short form(SMMSE-DS) in the Korean elderly. J Korean Geriatr Psychiatry 14(1):27–37
Huxtable RJ (1992) Physiological actions of taurine. Physiol Rev 72(1):101–163
Jin BS, Jeon MY (1999) A comparison of depression and anxiety in Alzheimer’ disease and vascular disease. J Korea Gerontol Soc 19(2):47–57
Jung KA, Lee YA, Kim SY, Chang NS (2008) Associations of cognitive function and dietary factors in elderly patients with Alzheimer’s disease. Korean J Nutr 41(8):718–732
Kalmijn S (2000) Fatty acid intake and the risk of dementia and cognitive decline: a review of clinical and epidemiological studies. J Nutr Health Aging 4(4):202–207
Kim CY (2006) The cognitive function and activities of daily living of the aged with dementia in the medical and welfare facilities for aged. Master’s thesis. Chung-Ang University, Seoul
Kim ES, Kim JS, Moon HK (1999) Taurine contents in commercial milks, meats and seafoods. J Korean Soc Food Sci Nutr 28(1):16–21
Kim ES, Kim JS, Yim MH, Jeong Y, Ko YS, Watanabe T, Nakatsuka H, Nakatsuka S, Matsuda-Inoguchi N, Shimbo S, Ikeda M (2003) Dietary taurine intakes and serum taurine levels of women in Jeju Island. Adv Exp Med Biol 526:277–283
Kim HJ, Kim HS, Kim KN, Kim GP, Son JI, Kim SY, Chang NS (2011) Relationship among plasma homocysteine, folate, vitamin B12 and nutrient intake and neurocognitive function in the elderly. Korean J Nutr 44(6):498–506
Kim HY, Kim HV, Yoon JH, Kang BR, Cho SM, Lee SJ, Kim JY, Kim JW, Cho YD, Woo JW, Kim YS (2014) Taurine in drinking water recovers learning and memory in the adult APP/PS1 mouse model of Alzheimer’s disease. Sci Rep 4:7467
Kim JE, Shin SA, Lee DW, Park JH, Hong EJ, Joung HJ (2015) Association between compliance with dietary guidelines and Alzheimer’s disease in Korean elderly. J Nutr Health 48(3):221–227
Kim JH, Kang SA, Ahn HS, Hung IK, Lee LH (1998) Relationship between cognitive function and dietary patterns in Korean elderly women. Korean J Nutr 31(9):1457–1467
Kim SH, Han SH (2012) Prevalence of dementia among the South Korean population. J Korean Diabetes 13(3):124–128
Kim SH, Jung JH (2013) The Correlation between cognitive function and basic activities of daily living of the elderly people with dementia in the residential care facilities. Soc Occup Ther Agged Dement 7(1):57–67
Kim JY (2009) The cognitive function, activities of daily living, anxiety, depression for the elderly people with dementia at residential care facilities. Nurs Sci 20(2):50–61
Lee HH (2008) A comparative study on the difference between demented seniles in day care center and demented senile-impatients in nursing fercility by analysing several indexes such as the performance status of daily activities, cognitive function and depressive symptoms. Master’s thesis. Ewha Womans University, Seoul
Luchsinger JA, Mayeux R (2004) Dietary factors and Alzheimer’s disease. Lancet Neurol 3:579–587
Morris MC, Evans DA, Bienias JL, Scherr PA, Tangney CC, Hebert LE, Bennett DA, Wilson RS, Aggarwal N (2004) Dietary niacin and the risk of incident Alzheimer’s disease and of cognitive decline. J Neurol Neurosurg Psychiatry 75(8):1093–1099
Park TS, Kang HW, Park JE, Cho SY (2001) Dietary intakes, plasma levels and urinary excretions of taurine in adolescents and adults residing in seoul Area. Korean J Nutr 34(4):440–448
Shinto L (2016) Eating seafood and cognitive decline in older adults. Neurology 86:e231–e233
Suh GH, Kim JK, Yeon BK, Park SK, Yoo KY, Yang BK, Kim YS, Cho MJ (2000) Prevalence and risk factors of dementia and depression in the elderly. J Korean Neuropsychiatr Assoc 39:809–824
The Korean Nutrition Society (2015) Dietary Reference Intakes For Koreans (KDRI). The Korean Nutrition Society, Seoul
Van Oijen M, de Long FJ, Hofman A, Koudstaal PJ, Breteler MMB (2007) Subjective memory complaints, education, and risk of Alzheimer’s disease. Alzheimers Dement 3:92–97
Wang HX, Wahlin A, Basun H, Fastbom J, Winblad B, Fratiglioni L (2001) Vitamin B(12) and folate in relation to the development of Alzheimer’s disease. Neurology 56(9):1188–1194
Wanga GH, Jianga ZL, Fanb XJ, Zhanga L, Lia X, Keb KF (2007) Neuroprotective effect of taurine against focal cerebral ischemia in rats possibly mediated by activation of both GABAA and glycine receptors. Neuropharmacology 52(5):1199–1209
Won JS, Kim JH (2003) Influencing factors on cognitive function and depression in elderly. J Korean Acad Psych Ment Health Nurs 12(2):148–154
Yim MH, Yang HR, Jung JI, Kim ES (2004) Comparison of Dietary Intakes, Urinary Excretions and Plasma Levels of Taurine in Women of Seoul and Kyunggi Area. J East Asian Soc Dietary Life 14(1):20–26
Yu SJ, Song SH, Lee GC (2015) Cognitive Function, Motor Function, and Functional Activity levels in Dementia Patients. J. Basic Sci 32:59–67
Zhou DF, Wu CS, Qi H, Fan JH, Sun XD, Como P, Qiao YL, Zhang L, Kieburtz K (2006) Prevalence of dementia in rural China: impact of age, gender and education. Acta Neurol Scand 114:273–280
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We thank the elderly with dementia, normal elderly, family caregivers, and staff in dementia daytime care centers and welfare center for helping with this research.
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Bae, M.A., Gao, R., Kim, S.H., Chang, K.J. (2017). Past Taurine Intake Has a Positive Effect on Present Cognitive Function in the Elderly. In: Lee, DH., Schaffer, S.W., Park, E., Kim, H.W. (eds) Taurine 10. Advances in Experimental Medicine and Biology, vol 975. Springer, Dordrecht. https://doi.org/10.1007/978-94-024-1079-2_6
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DOI: https://doi.org/10.1007/978-94-024-1079-2_6
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