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The peritoneal microcirculation

  • Chapter
Peritoneal dialysis

Abstract

The peritoneal membrane which surrounds the peritoneal cavity covers a maze of complex organs and tissues (e.g., stomach, small intestine, large intestine, liver, abdominal wall muscles, and mesentery). These tissues have independent and often dissimilar blood flow regulatory mechanisms. Thus, during peritoneal dialysis there are a multitude of very different vascular areas that are available for transfer of solutes from the blood, through the interstitial tissue and the peritoneal membrane, to the peritoneal cavity. The combined circulatory functions of these tissues will ultimately regulate the type and quantity of solutes eliminated by peritoneal dialysis. Aside from basic physiological differences among tissues, there are, in addition, numerous factors which can independently influence the local control of blood flow in these regions. Neural inputs, drugs, metabolic products, local hormones, excitement, exercise, and intestinal motility all may have a profound effect on the delivery of solutes (via peritoneal blood flow) to the areas of solute transport and on the permeability of the vasculature. In addition, diseases both systemic (e.g. hypertension) and local (e.g. peritonitis, cancer) have been shown to alter blood flow patterns or vascular permeability.

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Authors
  1. Frederick N. Miller
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Editors and Affiliations

  1. Division of Nephrology, University of Missouri Health Sciences Center, VA Hospital, and Dalton Research Center, Columbia, Missouri, USA

    Karl D. Nolph M.D.

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© 1985 Springer Science+Business Media Dordrecht

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Miller, F.N. (1985). The peritoneal microcirculation. In: Nolph, K.D. (eds) Peritoneal dialysis. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-2560-6_3

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  • DOI: https://doi.org/10.1007/978-94-017-2560-6_3

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