Abstract
Infectious salmon anaemia (ISA) is a viral disease of farmed Atlantic salmon (Salmo salar, Salmonidae). The disease has caused considerable economic loss to the Atlantic salmon farming industry. Initially, ISA was reported to occur in Norway, and for more than ten years the disease was only recognised in this country. Infectious salmon anaemia was recognised by the OIE in 1990 and the disease is listed in the OIE International Aquatic Animal Health Code (Office International des Epizooties (OIE), 1997b) and Diagnostic Manual for Aquatic Animal Diseases (Office International des Epizooties (OIE), 1997a) as one of the “Other significant diseases”. In European Union Directive 93/53/EEC the disease is classified on “the green list” as an exotic disease.
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References
Blake, S., Bouchard, D., Keleher, W., Opitz, M., and Nicholson, B.L. (1999). Genomic relationships of the North American isolate of infectious salmon anemia virus ( ISAV) to the Norwegian strain of ISAV. Dis Aquat Org 35, 139–144.
Bouchard, D., Keleher, W., Opitz, H.M., Blake, S., Edwards, K.C., and Nicholson, B.L. (1999). Isolation of infectious salmon anemia virus (ISAV) from Atlantic salmon in New Brunswick, Canada. Dis Aquat Org 35, 131–137.
Bouchard, D. A., Brockway, K., Giray, C., Keleher, W. & Merrill, P. L. (2001) First report of infectious salmon anemia ( ISA) in the United States. Bull Eur Ass Fish Pathol 21: 86–88.
Byrne, P.J., MacPhee, D.D., Ostland, V.E., Johnson, G., and Ferguson, H.W. (1998). Haemorrhagic kidney syndrome of Atlantic salmon, Salmo salar L. J Fish Dis 21, 81–91.
Cherian, T., Bobo, L., Steinhoff, M.C., Karron, R.A., and Yolken, R.H. (1994). Use of PCR-enzyme immunoassay for identification of influenza A virus matrix RNA in clinical samples negative for cultivable virus. J Clin Microbiol 32, 623–628.
Cunningham, C.O. and Snow, M. (2000). Genetic analysis of infectious salmon anaemia virus ( ISAV) from Scotland. Dis Aquat Org 41, 1–8.
Dannevig, B.H., Brudeseth, B.E., Gjeen, T., Rode, M., Wergeland, H.I., Evensen, 0., and Press, C.M. (1997). Characterisation of a long-term cell line (SHK-1) developed from head kidney of Atlantic salmon (Salmo salar L.). Fish Shellfish Immunol 7, 213–226.
Dannevig, B.H., Falk, K., and Namork, E. (1995a). Isolation of the causal virus of infectious salmon anaemia ( ISA) in a long-term cell line from Atlantic salmon head kidney. J Gen Virol 76, 13531359.
Dannevig, B.H., Falk, K., and Press, C.M. (1995b). Propagation of infectious salmon anaemia ( ISA) virus in cell culture. Vet Res 26, 438–442.
Dannevig, B.H., Falk, K., and Skjerve, E. (1994). Infectivity of internal tissues of Atlantic salmon, Salmo salar L., experimentally infected with the aetiological agent of infectious salmon anaemia ( ISA ). J Fish Dis 17, 613–622.
Devoid, M., Krossoy, B., Aspehaug, V., and Nylund, A. (2000). Use of RT-PCR for diagnosis of infectious salmon anaemia virus (ISAV) in carrier sea trout Salmo trutta after experimental infection. Dis Aquat Org 40, 9–18.
Donofrio, J.C., Coonrod, J.D., and Chambers, T.M. (1994). Diagnosis of equine influenza by the polymerase chain reaction. J Vet Diag Invest 6, 39–43.
Evensen, 0.,Thorud, K.E., and Olsen, Y. (1991). A morphological study of the gross and light microscopic lesions of infectious salmon anaemia in Atlantic salmon (Salmo salar). Res Vet Sci 51, 215–222.
Falk, K. and Dannevig, B.H. (1995). Demonstration of infectious salmon anaemia ( ISA) viral antigens in cell cultures and tissue sections. Vet Res 26, 499–504.
Falk, K., Namork, E., and Dannevig, B.H. (1998). Characterization and applications of a monoclonal antibody against infectious salmon anaemia virus. Dis Aquat Org 34, 77–85.
Falk, K., Namork, E., Rimstad, E., Mjaaland, S., and Dannevig, B.H. (1997). Characterisation of infectious salmon anemia virus, an orthomyxo-like virus isolated from Atlantic salmon (Salmon salar L.). J Virol 71, 9016–9023.
Fodor, E., Pritlove, D.C., and Brownlee, G.G. (1994). The influenza virus panhandle is involved in the initiation of transcription. J Virol 68, 4092–4096.
Hastings, T., Olivier, G., Cusack, R., Bricknell, I., Nylund, A., Binde, M., Munro, P., and Allan, C. (1999). Infectious salmon anaemia. Bull Eur Ass Fish Pathol 19, 286–288.
Hovland, T., Nylund, A., Watanabe, K., and Endresen, C. (1994). Observation of infectious salmon anaemia virus in Atlantic salmon, Salmo salar L. Journal of Fish Diseases 17, 291–296.
Hâstein, T. (1997) Infectious salmon anaemia (ISA). A historical and epidemiological review of the development and spread of the disease in Norwegian fish farms. In: Workshop on infectious salmon anaemia, 26 November 1997, St. Andrews, New Brunswick. Ed.: Hâstein, T. Oslo, National Veterinary Institute. pp 1–92.
Inglis, J.A., Bruce, J., and Cunningham, C.O. (2000). Nucleotide sequence variation in isolates of infectious salmon anaemia virus ( ISAV) from Scotland and Norway. Dis Aquat Org 43, 71–76.
Jarp, J., and Karlsen, E. (1997). Infectious salmon anaemia (ISA) risk factors in sea-cultured Atlantic salmon Salmo salar. Dis Aquat Org 28, 79–86.
Kibenge, F.S., Lyaku, J.R., Rainnie, D., and Hammelf, K.L. (2000a). Growth of infectious salmon anaemia virus in CHSE-214 cells and evidence for phenotypic differences between virus strains. J Gen Virol 81, 143–150.
Kibenge, F. S. B., Whyte, S. K., Hammett, K. L., Rainnie, D., Kibenge, M. T., and Martin, C. K. (2000b) A dual infection of infectious salmon anaemia (ISA) virus and a togavirus-like virus in ISA of Atlantic salmon Salmo salar in New Brunswick, Canada. Dis Aquat Org 42, 11–15.
Kibenge, F. S. B., Garate, O. N., Johnson, G., Arriagada, R., Kibenge, M. J. T. & Wadowska, D. (2001) Isolation and identification of infectious salmon anaemia virus ( ISAV) from Coho salmon in Chile. Dis Aquat Org 45: 9–18.
Krossay, B., Hordvik, I., Nilsen, F., Nylund, A., and Endresen, C. (1999). The putative polymerase sequence of infectious salmon anemia virus suggests a new genus within the Orthomyxoviridae. J Virol 73, 2136–2142.
Lovely, J.E., Dannevig, B.H., Falk, K., Hutchin, L., MacKinnon, A.M., Melville, K.J., Rimstad, E., and Griffiths, S.G. (1999). First identification of infectious salmon anaemia virus in North America with haemorrhagic kidney syndrome. Dis Aquat Org 35, 145–148.
McBeath, A.J.A., Burr, K.L-A., and Cunningham, C.O. (2000). Development and use of a DNA probe for confirmation of cDNA from infectious salmon anaemia virus ( ISAV) in PCR products. Bull Eur Ass Fish Pathol 20, 130–134.
Melville, K.J., and Griffiths, S.G. (1999). Absence of vertical transmission of infectious salmon anemia virus (ISAV) from individually infected Atlantic salmon Salmo salar. Dis Aquat Org 38, 231–234.
Mikalsen, A.B, Teig, A., Heileman, A.-L., Mjaaland, S., and Rimstad, E. (in press) Detection of infectious salmon anaemia virus (ISAV), by RT-PCR after cohabitant exposure in Atlantic salmon (Salmo salar L.) Dis Aquat Org.
Mjaaland, S., Rimstad, E., Falk, K., and Dannevig, B.H. (1997). Genome characterization of the virus causing infectious salmon anemia in Atlantic salmon (Salmo salar L.): an orthomyxo-like virus in a teleost. J Virol 71, 7681–7686.
Mullins, J.E., Groman, D., and Wadowska, D. (1998). Infectious salmon anaemia in salt water Atlantic salmon (Salmo salar L.) in New Brunswick, Canada. Bull Eur Ass Fish Pathol 18, 110–114.
Nylund, A., and Jakobsen, P. (1995). Sea trout as a carrier of infectious salmon anaemia virus. J Fish Biol 47, 174–176.
Nylund, A., Kvenseth, A.M., and Krossoy, B. (1995a). Susceptibility of wild salmon (Salmo salar L.) to infectious salmon anaemia ( ISA ). Bull Eur Ass Fish Pathol 15, 152–156.
Nylund, A., Hovland, T., Watanabe, K., and Endresen, C. (1995b). Presence of infectious salmon anaemia virus (ISAV) in tissues of Atlantic salmon, Salmo salar L., collected during three separate outbreaks of the disease. J Fish Dis 18, 135–145.
Nylund, A., Alexandersen, S., Rolland, J.B., and Jakobsen, P. (1995c). Infectious salmon anemia virus ( ISAV) in brown trout. J Aquat Animal Health 7, 236–240.
Nylund, A., Kvenseth, A.M., Krossey, B., and Hodneland, K. (1997). Replication of the infectious salmon
anaemia virus (ISAV) in rainbow trout, Oncorhynchus mykiss (Walbaum). J Fish Dis 20, 275–279.
O’Halloran, J.L., L’Aventure, J.P., Groman, D.B., and Reid, A.M. (1999). Infectious salmon anemia in Atlantic salmon. Can Vet J. 40, 351–352.
Office International des Epizooties (OIE) (1997a). Diagnostic Manual for Aquatic Animal Diseases. (Paris: 01E ), p. 251.
Office International des Epizooties (OIE) (1997b). International Aquatic Animal Health Code. ( Paris: OIE ), p. 192.
Opitz, H.M., Bouchard, D., Anderson, E., Blake, S., Nicholson, B.L., and Keleher, W. (2000). A comparison of methods for the detection of experimentally induced subclinical infectious salmon anaemia in Atlantic salmon. Bull Eur Ass Fish Pathol 20, 12–22.
Raynard, R. S. (2000) A survey of wild fish in Scotland for evidence of infectious salmon anaemia virus - report for the period May 1998 to December 1999. FRS Marine Laboratory, Aberdeen. Report 05 /00. 17 pp.
Raynard, R. S., King, J. A., Snow, M., Munro, A. L. S., Olesen, N. J., and Mortensen, H. F. (1999) Virulence of marine isolates of viral haemorrhagic septicaemia virus in Atlantic salmon and turbot. EAFP 9th International Conference “Diseases of Fish and Shellfish”, Rhodes, Greece 1924th September 1999, 0–015.
Raynard, R. S., Murray, A. G., and Gregory, A. (in press). Infectious salmon anaemia virus in wild fish from Scotland. Dis Aquat Org
Rimstad, E., Falk, K., Mikalsen, A.B., and Teig, A. (1999). Time course tissue distribution of infectious salmon anaemia virus in experimentally infected Atlantic salmon Salmo salar. Dis Aquat Org 36, 107–112.
Rimstad, E., Mjaaland, S., Snow, M., Mikalsen, A.B., and Cunningham, C.O. (2001). Characterisation of the infectious salmon anemia virus genomic segment that encodes the putative hemagglutinin. J Virol 75, 5352–5356.
Ritchie, R. J., Bardiot, A., Melville, K., Griffiths, S., Cunningham, C. O., and Snow, M. (in prep.) Characterisation of the genomic segment encoding the putative matrix proteins of Infectious Salmon Anaemia Virus (ISAV).
Ritchie, R. J., Cook, M., Mellville, K., Simard, N., Cusack, R., and Griffiths, S. (2001a) Identification of infectious salmon anaemia virus in Atlantic salmon from Nova Scotia (Canada): evidence for functional strain differences. Dis Aquat Org 44: 171–178.
Ritchie, R. J., Heppell, J., Cook, M. B., Jones, S., and Griffiths, S. G. (2001b) Identification and characterization of segments 3 and 4 of the ISAV genome. Virus Genes 22: 289–297.
Rodger, H.D., Turnbull, T., Muir, F., Millar,S., and Richards, RH. (1998). Infectious salmon anaemia ( ISA) in the United Kingdom. Bull Eur Ass Fish Pathol 18, 115–116.
Rolland, J.B., and Nylund, A. (1998b). Infectiousness of the organic materials originating in ISA-infected fish and transmission of the disease via salmon lice (Lepeophtheirus salmonis). Bull Eur Ass Fish Pathol 18, 173–180.
Rolland, J.B., and Nylund, A. (1998a). Sea running brown trout: carrier and transmitter of the infectious salmon anemia virus ( ISAV ). Bull Eur Ass Fish Pathol 18, 50–55.
Sandvik, T., Rimstad, E., and Mjaaland, S. (2000). The viral RNA 3’- and 5’-end structure and mRNA transcription of infectious salmon anaemia virus resemble those of influenza viruses. Arch Virol 145, 1659–1669.
Sellner, L.N., and Turbett, G.R. (1998). Comparison of three RT-PCR methods. Biotech 25, 230–234.
Snow, M., and Cunningham, C. 0. (2001) Characterisation of the putative nucleoprotein gene of infectious salmon anaemia virus ( ISAV ). Virus Res 74, 111–118.
Sommer, A.I., and Mennen, S. (1997). Multiplication and haemadsorbing activity of infectious salmon anaemia virus in the established Atlantic salmon cell line. J Gen Virol 78, 1891–1895.
Stagg, R., Bruno, D., Cunningham, C., Hastings, T., and Bricknell, I. (1999). Focus on infectious salmon anaemia: Epizootiology and pathology. State Vet J 9, 1–5.
Stagg, R. M., Bruno, D. W., Cunningham, C. O., Raynard, R. S., Munro, P. D., Murray, A. G., Allan, C. E. T., Smail, D. A., McVicar, A. H., and Hastings, T. S. (2001). Epizootiological investigations into an outbreak of infectious salmon anaemia (ISA) in Scotland. FRS Marine Laboratory, Aberdeen Report 13 /01: 60 pp.
Thorud, K. E. (1991) Infectious salmon anaemia. Transmission trials. Haematological, clinical, chemical and morphological investigations. Norwegian College of Veterinary Medicine, PhD thesis. Thorud, K.E., and Djupvik, H.O. (1988). Infectious anaemia in Atlantic salmon (Salmo salar L.). Bull Eur Ass Fish Pathol 8, 109–111.
Thorud, K.E., and Torgersen, Y. (1994). Regnbueorret og sjeorretkan vere passive smitteberere av ILA. Norsk Fiskeoppdrett 11A, 54–55 (in Norwegian).
Totland, G.K., Hjeltnes, B.K., and Flood, P.R. (1996). Transmission of infectious salmon anaemia (ISA) through natural secretions and excretions from infected smolts of Atlantic salmon Salmo salar during their presymptomatic phase. Dis Aquat Org 26, 25–31.
Vâgsholm, I., Djupvik, H.O., Willumsen, F.V., Tveit, A.M., and Tangen, K. (1994). Infectious salmon anaemia ( ISA) epidemiology in Norway. Prey Vet Med 19, 277–290.
Wergeland, H. I., and Jakobsen, R. A. (2001) A salmonid cell line (TO) for production of infectious salmon anaemia virus ( ISAV ). Dis Aquat Org 44: 183–190.
Øye, A-K, and Rimstad, E. (In prep.) Inactivation of infectious salmon anaemia virus, viral haemorrhagic septicaemia virus and infectious pancreatic necrosis virus in water using UVC irradiation.
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Mjaaland, S., Rimstad, E., Cunningham, C.O. (2002). Molecular Diagnosis of Infectious Salmon Anaemia. In: Cunningham, C.O. (eds) Molecular Diagnosis of Salmonid Diseases. Reviews: Methods and Technologies in Fish Biology and Fisheries, vol 3. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-2315-2_1
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DOI: https://doi.org/10.1007/978-94-017-2315-2_1
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