Abstract
The ethanol extract of the roots of Pelargonium sidoides (Geraniaceae) has yielded three novel coumarin sulfates, including 5,6-dimethoxycoumarin 7-sulfate and a mixture of the 6- and 8-monosulfate of 6,8-dihydroxy-5,7-dimethoxycoumarin. Their structures were determined unambiguously by comprehensive analyses of their NMR and MS data. Attempts to synthesize these compounds by adopting the dicyclohexylcarbodiimide-mediated esterification of their parent highly oxygenated coumarins with tetrabutylammonium hydrogen sulfate were unsuccessful. In contrast, this method was useful for the sulfation of a series of mono- and dioxygenated coumarins in a model reaction.
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© 2002 Springer Science+Business Media Dordrecht
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Kolodziej, H., Kayser, O., Tan, N. (2002). Novel Coumarin Sulfates from Pelargonium sidoides . In: Rauter, A.P., Palma, F.B., Justino, J., Araújo, M.E., dos Santos, S.P. (eds) Natural Products in the New Millennium: Prospects and Industrial Application. Proceedings of the Phytochemical Society of Europe, vol 47. Springer, Dordrecht. https://doi.org/10.1007/978-94-015-9876-7_3
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DOI: https://doi.org/10.1007/978-94-015-9876-7_3
Publisher Name: Springer, Dordrecht
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