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PET Radiopharmaceutical Metabolism — Plasma Metabolite Analysis

  • Chapter
Radiopharmaceuticals for Positron Emission Tomography

Part of the book series: Developments in Nuclear Medicine ((DNUM,volume 24))

Abstract

PET radiopharmaceutical metabolism is discussed in general. Methodology for determining the proportion of unchanged radiopharmaceutical in plasma is discussed with regard to preparation of sample, current analytical techniques, sources of errors and pitfalls. The literature on metabolite analysis in plasma is discussed for several popular radiopharmaceuticals, including labelled amino acids, flow tracers and radioligands for acetylcholine, adrenergic, benzodiazepine, dopamine and serotonin receptors.

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Authors
  1. Bernard Mazière
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  2. Robert Cantineau
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  3. Heinz H. Coenen
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  4. Marcel Guillaume
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  5. Christer Halldin
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  6. André Luxen
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  7. Christian Loc’h
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  8. Sajinder K. Luthra
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Editors and Affiliations

  1. Institut für Nuklearchemie, Forschungszentrum Jülich GmbH, Postfach 1913, D-5170, Jülich, Germany

    Gerhard Stöcklin

  2. MRC Cyclotron Unit, Hammersmith Hospital, Ducane Road, W12 OHS, London, UK

    Victor W. Pike

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Mazière, B. et al. (1993). PET Radiopharmaceutical Metabolism — Plasma Metabolite Analysis. In: Stöcklin, G., Pike, V.W. (eds) Radiopharmaceuticals for Positron Emission Tomography. Developments in Nuclear Medicine, vol 24. Springer, Dordrecht. https://doi.org/10.1007/978-94-015-8204-9_4

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  • DOI: https://doi.org/10.1007/978-94-015-8204-9_4

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