Abstract
Receptor-mediated endocytosis is a constitutive cellular process that accounts for the specific uptake of a wide variety of macromolecules from the extracellular environment (1,2). The process subserves manifold cellular functions including the supply of metals, vitamins, and metabolites necessary for cell growth and well being. Also, endocytosis regulates the composition of the extracellular environment by selectively internalizing molecules from the extracellular medium. All mammalian cells carry out some level of receptor-mediated endocytosis. Phagocytosis is a receptor-mediated process which, unlike endocytosis (notwithstanding peptide hormone induced receptor internalization), is triggered by receptor-ligand engagement (3). In vertebrates, phagocytosis is carried out by a limited number of cell types, mostly those involved in host defense.
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References
Schwartz AL. Cell Biology of Intracellular Trafficking. Ann Rev Immunol 1990, 8:195–229.
Wileman T, Harding C, Stahl P. Receptor-mediated endocytosis. Biochem J, 1985, 232:1–14.
Silverstein SC, Greenberg S, Di Virgilio F, Steinberg TH. Phagocytosis. In: Fundamental Immunology. Paul WE, Ed. Raven Press 1989, pp. 703–719.
Brodsky FM. Living with clathrin: Its role in intracellular membrane traffic. Science 1988, 242:1396–1402.
Pearse BMF, Robinson MS. Clathrin, adaptors, and sorting. Ann Rev Cell Biol 1990, 6:151–171.
Stone DK, Crider BP, Sudhof TC, Xie X-S. Vacuolar proton pumps. J Bioenerg Biomem 1989, 21:605–620.
Rothman JE, Orci L. Movement of proteins through the Golgi stack: a molecular dissection of vesicular transport. FASEB J 1990, 4:1460–1468.
Balch WE. Biochemistry of interorganellar transport. J Biol Chem 1989, 264:16965–16968.
Novick P, Schekman R. Secretion and cell surface growth are blocked in a temperature-sensitive mutant of Sacchar-omyces cerevisiae. Proc Natl Acad Sci USA 1979, 76:1858–1862.
Diaz R, Mayorga L, Stahl P. In vitro fusion of endosomes following receptor-mediated endocytosis. J Biol Chem 1988, 263:6093–6100.
Keller RK, Touster O. Physical and chemical properties of ß-glucuronidase from the preputial glands of the female rat. J Biol Chem 1975, 250:4765–4769.
Bradford MM. A rapid and sensitive method for the quantitation of micrograms quantities of protein by the principle of protein-dye binding. Anal Biochem 1976, 72:248–254.
Mayorga LM, Bertini F, Stahl PD. Fusion of newly formed phagosomes with endosomes in intact cells and in a cell-free system. J Biol Chem 1991, 266:6511–6517.
Diaz R, Mayorga LS, Weidman PJ, Rothman JE, Stahl PD. Vesicle fusion following receptor-mediated endocytosis requires a protein active in Golgi transport. Nature 1989, 339:398–400.
Mayorga LS, Diaz R, Colombo MI, Stahl PD. GTP7S stimulation of endosome fusion suggests a role for a GTP-binding protein in the priming of vesicles before fusion. Cell Reg 1989, 1:113–124.
Chavrier P, Parton RG, Hauri HP, Simons K, Zerial M. Localization of low molecular weight GTP-binding proteins to exocytic and endocytic compartments. Cell 1990, 62:317–329.
Joiner KA, Fuhrman SA, Miettinen HM, Kasper I, Mell-man I. Toxoplasma gondii: fusion competence of parasi-tophorous vacuoles in Fc receptor-transfected fibroblasts. Science 1990, 249:641–649.
Diaz R, Mayorga LS, Mayorga LE, Stahl PD. In vitro clustering and multiple fusion among macrophage endosomes. J Biol Chem 1989, 264:13171–13180.
Mayorga L, Diaz R, Stahl P. Plasma membrane-derived vesicles containing receptor-ligand complexes are fuso-genic with early endosomes in a cell-free system. J Biol Chem 1988, 263:17213–17216.
Mayorga L, Diaz R, Stahl P. Regulatory role for GTP-binding proteins in endocytosis. Science 1989, 244:1475–1477.
Gorvel J-P, Chavrier P, Zerial M, Gruenberg J. rab5 controls early endosome fusion in vitro. Cell 1991, 64:915–925.
Clary JO, Griff IC, Rothman JE. SNAPs, a family of NSF attachment proteins involved in intracellular membrane fusion in animals and yeast. Cell 1990, 61:709–721.
Muller WA, Steinman RM, Cohn ZA. The membrane proteins of the vacuolar system II. Bidirectional flow between secondary lysosomes and plasma membrane. J Cell Biol 1980, 86:304–314.
Pitt A, Mayorga LS, Schwartz AL, Stahl PD. Recycling of phagosomal components to an endosomal compartment. 1991. Submitted.
Harding CV, Collins DS, Slot JW, Geuze HJ, Unanue ER. Liposome-encapsulated antigens are processed in lysosomes, recycled, and presented to T cells. Cell 1991, 64:393–401.
Peters PJ, Neefjes JJ, Oorschot V, Ploegh HL, Geuze HJ. Segregation of MHC class II molecules from MHC class I molecules in the Golgi complex for transport to lysosomal compartments. Nature 1991, 349:669–676.
Lang T, de Chastellier C, Ryter A, Thilo L. Endocytic membrane traffic with respect to phagosomes in macrophages infected with non-pathogenic bacteria: phagosomal membrane acquires the same composition as lysosomal membrane. Eur J Cell Biol 1988, 46:39–50.
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© 1992 Springer Science+Business Media Dordrecht
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Mayorga, L.S., Pitt, A., Stahl, P.D. (1992). Receptor-mediated endocytosis and phagocytosis share common determinants for intracellular traficking. In: van Furth, R. (eds) Mononuclear Phagocytes. Springer, Dordrecht. https://doi.org/10.1007/978-94-015-8070-0_29
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DOI: https://doi.org/10.1007/978-94-015-8070-0_29
Publisher Name: Springer, Dordrecht
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