Skip to main content

Abstract

Fifty years ago Cori and Cori1 3 directed the attention of biochemists to differences in the metabolism of lactic acid isomers in the rat, and in 1964 Dunlop and associates1 9 described D-Iactic acidaemia in the bovine after overloading the rumen with carbohydrates — possibly the first ‘isomeric disease’. Since then authors like Dirksen, Huber, Juhasz and others have contributed markedly to the knowledge of pathogenesis of lactic acidosis. A full account of rumen acidosis and its clinical consequences has been given elsewhere1 7.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Alexander, E. and Davies, M. E. (1963). Production and fermentation of lactate by bacteria in’the alimentary canal of the horse and pig. J. Comp. Pathol. Ther., 73, 1–8

    CAS  Google Scholar 

  2. Annison, E. F., Lindsay, D. E. and White, R. R. (1963). Metabolic interrelations of glucose and lactate in sheep. Biochem. J., 88, 243–248

    PubMed  CAS  Google Scholar 

  3. Battaglia, F. C. and Meshia, G. (1978). Principal substrates of fetal metabolism. Physiol. Rev., 58, 499–527

    PubMed  CAS  Google Scholar 

  4. Bergman, E. N. and Wolff, J. E. (1971). Metabolism of volatile fatty acids by liver and portal drained viscera in sheep. Am. J. Physiol., 221, 586–592

    PubMed  CAS  Google Scholar 

  5. Brockman, R. P., Bergman, E. N., Pollak, W. C. and Brondum, J. (1975). Studies of glucose production in sheep using (6-3H)gIucose and (U-14C) glucose. Can. J. Physiol., 53, 1186–1189

    Article  CAS  Google Scholar 

  6. Brüggemann, J. and Giesecke, D. (1968). Adaptationsvorgänge im Pansen bei Dauerinfusion von Milchsäure. Z. Tierphysiol. Tierern. Futtermittelkd., 24, 290–298

    Article  Google Scholar 

  7. Burd, L. J., Jones, M. D., Simmons, M. A., Makowski, E. L., Meschia, G. and Battaglia, F. C. (1975). Placental production and foetal utilization of lactate and pyruvate. Nature (London), 254, 710–711

    Article  CAS  Google Scholar 

  8. Cammack, R. (1969). Assay, purification and properties of mammalian o-2-hydroxy acid dehydrogenase. Biochem. J., 115, 55–64

    PubMed  CAS  Google Scholar 

  9. Cammack, R. (1970). Mammalian D-2-hydroxy acid dehydrogenase. Effect of inhibitors and reaction sequence. Biochem. J., 118, 405–408

    PubMed  CAS  Google Scholar 

  10. Char, V. and Creasy, R. K. (1976). Acetate as a metabolic substrate in the fetal lamb. Am. J. Physiol., 230, 357–361

    PubMed  CAS  Google Scholar 

  11. Chinard, F. P., Enns, T. and Nolan, M. F. (1962). Indicator dilution studies with ‘diffusible’ indicators. Circ. Res., 10, 473–490

    PubMed  CAS  Google Scholar 

  12. Comline, R. S. and Silver, M. (1976). Some aspects of foetal and utero-placental metabolism in cows with indwelling umbilical uterine vascular catheters. J. Physiol. (London), 260, 571–586

    CAS  Google Scholar 

  13. Cori, C. F. and Cori, G. T. (1929). Glycogen formation in the liver from d- and 1-lactic acid. J. Biol. Chem., 81, 389–403

    CAS  Google Scholar 

  14. Craig, F. N. (1946). Renal tubular reabsorption, metabolic utilization, and isomeric fractionation of lactic acid in the dog. Am. J. Physiol., 146, 146–159

    PubMed  CAS  Google Scholar 

  15. Cranwell, P. D., Noakes, D. E. and Hill, K. J. (1976). Gastric secretion and fermentation in the suckling pig. Br. J. Nutr., 36, 71–86

    Article  PubMed  CAS  Google Scholar 

  16. Dies, F., Ramos, G., Alvelar, E. and Lennhoff, M. (1969). Renal excretion of lactic acid in the dog. Am. J. Physiol., 216, 106–111

    PubMed  CAS  Google Scholar 

  17. Dunlop, R. H. (1972). Pathogenesis of ruminant lactic acidosis. Adv. Vet. Sci. Comp. Sci., 16, 259–302. (New York - London: Academic Press)

    CAS  Google Scholar 

  18. Dunlop, R. H. and Hammond, P. B. (1965). D-Iactic acidosis of the ruminants. Ann. NY Acad. Sci., 119, 1109–1132

    Article  PubMed  CAS  Google Scholar 

  19. Dunlop, R. H., Hammond, P. B. and Stevens, C. E. (1964). d-lactate in bovine blood following carbohydrate engorgement. Fed. Proc. Fed. Am. Soc. Exp. Biol., 23, 262

    Google Scholar 

  20. Forbath, N., Hall, J. D. and Hetenyi, G. (1969). Effect of methylprednisolone and ACTH on lactate turnover and its conversion to glucose. Hormone Metab. Res., 1, 178–182

    Article  CAS  Google Scholar 

  21. Giesecke, D. (1973). Biologie und Biochemie der Bakterien im Pansen. In D. Giesecke und H. K. Henderickx (eds.) Biologie und Biochemie der mikrobiellen Verdauung, pp. 9–57. (München - Bern - Wien: BLV-Verlagsgesellschaft)

    Google Scholar 

  22. Giesecke, D. (1973). Mikrobielle Besiedlung und funktionelle Entwicklung des Vormagens der Wiederkäuer. In D. Giesecke und H. K. Henderickx (eds.) Biologie und Biochemie der mikrobiellen Verdauung, pp. 108–125. (München - Bern - Wien: BLV-Verlagsgesellschaft)

    Google Scholar 

  23. Giesecke, D. and Fabritius, A. (1974). Oxidation and excretion of d-Iactic acid by rats. Experientia, 30, 1124

    Article  PubMed  CAS  Google Scholar 

  24. Giesecke, D. and Geiges, R. (1974). Untersuchungen zur Genese und Biochemie der Pansenacidose. 1. Stärke, Amylaseaktivität und Acidität. Zbl. Vet. Med. A., 21, 261–267

    CAS  Google Scholar 

  25. Giesecke, D. and Stangassinger, M. (1976). Rumen acidosis and metabolic kinetics of D(-) lactic acid. Proceedings of the 3rd International Conference on Production Disease in Farm Animals, pp. 85–87, 13–16 September, Wageningen, The Netherlands

    Google Scholar 

  26. Giesecke, D. and Stangassinger, M. (1978). Untersuchungen zur Genese und Biochemie der Pansenacidose. 5. Kinetik der Elimination von D(-) Milchsäure aus dem Blut. Zbl. Vet. Med. A, 25, 327–337

    CAS  Google Scholar 

  27. Giesecke, D. and Stangassinger, M. (1979). Untersuchungen zur Genese und Biochemie der Pansenacidose. 7. Oxydationsrate und quantitative Gluconeogenese aus D-Lactat (14C) bei Ziegen. Zbl. Vet. Med. A, 26 85–94

    CAS  Google Scholar 

  28. Giesecke, D., Bartelmus, C. and Stangassinger, M. (1976). Untersuchungen zur Genese und Biochemie der Pansenacidose. 3. Stoffwechseldynamik von D(-)-und L(+)-MiIchsäure nach Verabreichung von Zuckern und nach Überfütterung mit Stärke. Zbl. Vet. Med. A, 23, 353–363

    CAS  Google Scholar 

  29. Harmeyer, J. (1973). Protozoologie des Pansens. In D. Giesecke und H. K. Henderickx (eds.) Biologie und Biochemie der mikrobiellen Verdauung, pp. 58–107. (München- Bern - Wien: BLV-Verlagsgesellschaft)

    Google Scholar 

  30. Henderson, H. E., Reddy, C. A. and Crickenberger, R. (1974). Fermented ammoniated condensed whey (FACW) as a protein source. J. Anim. Sci., 39, 240

    Google Scholar 

  31. Hildmann, B., Lücke, H., Barac-Nieto, M. and Murer, H. (1978). Lactate-sodium cotransport in rabbit small intestinal brush border membranes. Abstr. Eur. Intestinal Transport Group, 2nd Meeting, No. 32

    Google Scholar 

  32. Hinkson, R. S., Hoover, W. H. and Poulton, B. R. (1967). Metabolism of lactate isomers by rat and sheep liver and by rumen epithelial tissue. J. Anim. Sci., 26, 799–803

    PubMed  CAS  Google Scholar 

  33. Huber, T. L. (1969). Effect of ration on liver oxidation of racemic lactate and of thiamine on blood lactate clearance. J. Anim. Sci., 28, 98–102

    PubMed  CAS  Google Scholar 

  34. Huber, J. T., Boman, R. L. and Henderson, H. E. (1976). Fermented ammoniatedcondensed whey as a nitrogen supplement for lactating cows. J. Dairy Sci., 59, 1936–1943

    Article  CAS  Google Scholar 

  35. Huntington, G. and Britton, R. (1978). Effect of dietary lactic acid content and energy level on rumen lactate metabolism in sheep. J. Anim. Sci., 47, 241–246

    PubMed  CAS  Google Scholar 

  36. Jarrett, I. G., Filsell, O. H. and Ballard, F. J. (1976). Utilization of oxidizable substrates by the sheep hind limbs. Effects of starvation and exercise. Metabolism, 25, 523–531

    Article  PubMed  CAS  Google Scholar 

  37. Judson, G. J. and Leng, R. A. (1972). Estimation of the total entry rate and resynthesis of glucose in sheep using glucose uniformly labelled with 3H. Aust. J. Biol. Sci., 25, 1313–1332

    PubMed  CAS  Google Scholar 

  38. Juhâsz, E., Szegedi, B. and Keresztes, M. (1976). The abomasal digestion in calves during development of the forestomachs. Acta Vet. Acad. Sci. Hung., 26, 281–295

    PubMed  Google Scholar 

  39. Koch, G., Ledinek, M. and Giesecke, D. (1972). Untersuchungen über die Beteiligung von Mikroorganismen am Verdauungsstoffwechsel des Schweines. Z. Tierphysiol. Tierern. Futtermittelkd., 30, 222–231

    Article  CAS  Google Scholar 

  40. Krebs, H. A., Hems, R., Weidemann, M. J. and Speake, R. N. (1966). The fate of isotopic carbon in kidney cortex synthesizing glucose from lactate. Biochem. J., 101, 242–249

    PubMed  CAS  Google Scholar 

  41. Kreisberg, R. A., Siegal, A. M. and Owen, W. C. (1971). Glucose lactate interrelationships. Effect of ethanol. J. Clin. Invest., 50, 175–184

    Article  PubMed  CAS  Google Scholar 

  42. Leal-Pinto, E., Park, H. C., King, F, MacLeod, M. and Pitts, R. F. (1973). Metabolism of lactate by the intact functioning kidney of the dog. Am. J. Physiol., 224, 1463–1467

    PubMed  CAS  Google Scholar 

  43. Leng, R. A., Steel, J. W. and Luick, J. R. (1967). Contribution of propionate to glucose synthesis in sheep. Biochem. J., 103, 785–790

    PubMed  CAS  Google Scholar 

  44. Levy, M. N. (1962). Uptake of lactate and pyruvate by intact kidney of the dog. Am. J. Physiol., 202, 302–308

    PubMed  CAS  Google Scholar 

  45. Lindena, J. (1975). Untersuchungen zur Kinetik des Lactatstoffwechsels beim Hausschwein. Vet. Med. Diss. Hannover

    Google Scholar 

  46. Man, N. K., Keller, P., Hallauer, W. and Schirmeister, J. (1969). Über den Mechanismus der renalen Lactatbearbeitung beim Menschen. Klin. Wschr., 47, 1170–1172

    Article  PubMed  CAS  Google Scholar 

  47. Miller, O. N. and Bazzano, G. (1965). Propanediol metabolism and its relation to lactic acid metabolism. Ann. NY Acad. Sci., 111, 957–973

    Google Scholar 

  48. Nemoto, E. M. and Sevringhaus, J. W. (1971). The stereospecific influx permeability of rat blood-brain barrier (BBB) to lactic acid (LA). Clin. Res., 19, 146

    Google Scholar 

  49. Ogimoto, K. (1977). Microbial investigation of the lactic acid metabolic system in the rumen of feedlot catties. Proc. Anim. Nutri. Metab., 21, 74–86

    Google Scholar 

  50. Ogimoto, K. and Giesecke, D. (1974). Untersuchungen zur Genese und Biochemie der Pansenacidose. 2. Mikroorganismen und Umsetzung von Milchsäure-Isomeren. Zbl. Vet. Med. A, 21, 532–538

    CAS  Google Scholar 

  51. Oldendorf, W. H. (1973). Carrier-mediated blood-brain barrier transport of short- chain mono-carboxylic organic acids. Am. J. Physiol, 224, 1450–1453

    PubMed  CAS  Google Scholar 

  52. Preston, A. M. and Noller, C. H. (1973). Metabolism of d-lactate by tissues of the ruminant digestive tract. J. Anim. Sci., 37, 1403–1407

    PubMed  CAS  Google Scholar 

  53. Prins, R. A. and van Hoven, W. (1977). Carbohydrate fermentation by the rumen ciliate Isotricha prostoma. Protistologica, XIII, 549–556

    Google Scholar 

  54. Prins, R. A. and Lankhorst, A. (1976). Factors affecting lactate metabolism in the rumen. Proceedings of the 3rd International Conference on Production Disease in Farm Animals, pp. 88–91, 13–16 September, Wageningen, The Netherlands

    Google Scholar 

  55. Prior, R. L. (1978). Effect of level of feed intake on lactate and acetate metabolism and lipogenesis in vivo in sheep. J. Nutr., 108, 926–935

    PubMed  CAS  Google Scholar 

  56. Prior, R. L. and Christenson, R. K. (1977). Gluconeogenesis from alanine in vivo by the ovine fetus and lamb. Am. J. Physiol, 233, E462-E468

    PubMed  CAS  Google Scholar 

  57. Reilly, P. E. B. and Chandrasena, L. G. (1977). Sheep lactate entry measurements: Error due to sampling jugular blood. Am. J. Physiol, 233, E138-E140

    PubMed  CAS  Google Scholar 

  58. Reilly, P. E. B. and Chandrasena, L. G. (1978). Glucose lactate interrelations in sheep. Am. J. Physiol, 235, E487-E492

    PubMed  CAS  Google Scholar 

  59. Rohr, K., Honig, H. and Daenicke, R. (1974). Biologische Kenndaten verschiedener Konservierungsverfahren. Das wirtschaftseigene Futter, 20, 277–287

    Google Scholar 

  60. Roos, A. (1975). Intracellular pH and distribution of weak acids across cell membranes. A study of d- and l-Iactate and of DMO in rat diaphragm. J. Physiol, 249, 1–25

    PubMed  CAS  Google Scholar 

  61. Schwartz, H. M. and Gilchrist, F. M. C. (1975). Microbial interactions with the host animal. In I. W. McDonald and A. C. I. Warner (eds.) Digestion and Metabolism in the Ruminant, pp. 165–179. (Armidale: Univ. New England Publ. Unit)

    Google Scholar 

  62. Searle, G. L. and Cavalieri, R. R. (1972). Determination of lactate kinetics in the human; analysis of data from single injection vs. continuous infusion methods. Proc. Soc. Exp. Biol. Med., 139, 1002–1006

    PubMed  CAS  Google Scholar 

  63. Slyter, L. L. (1976). Influence of acidosis on rumen function. J. Anim. Sci., 43, 910–929

    PubMed  CAS  Google Scholar 

  64. Stangassinger, M. and Giesecke, D. (1977). Untersuchungen zur Genese und Biochemie der Pansenacidose. 4. Verteilung von d(-) Milchsäure nach Infusion bei Ziege, Schaf und Rind. Zbl. Vet. Med. A., 24, 789–798

    CAS  Google Scholar 

  65. Stangassinger, M. and Giesecke, D. (1978). Untersuchungen zur Genese und Biochemie der Pansenacidose. 6. Renale Ausscheidung von Milchsäure-Isomeren. Zbl. Vet. Med. A, 25, 597–607

    CAS  Google Scholar 

  66. Storelli, C., Corcelli, A. and Lippe, C. (1978). l-Iactate uptake in intestinal brush border vesicles. Abstr. Eur. Intestinal Transport Group, 2nd Meeting No. 31

    Google Scholar 

  67. Tubbs, P. K. (1965). The metabolism of d-a-hydroxy acids in animal tissues. Ann. NY Acad. Sci., 119, 920–926

    Article  PubMed  CAS  Google Scholar 

  68. Wallace, R. J. (1978). Control of lactate production by Selenomonas ruminantium. Homotropic activation of lactate dehydrogenase by pyruvate. J. Gen. Microbiol., 107, 45–52

    PubMed  CAS  Google Scholar 

  69. Ward, J. K., Richardson, D. and Tsien, W. S. (1961). Volatile fatty acid concentrations and proportions in the gastrointestinal tract of full-fed beef heifers. J. Anim. Sci., 20, 830–832

    Google Scholar 

  70. Weekes, T. E. C. (1974). The in vitro metabolism of propionate and glucose by the rumen epithelium. Comp. Biochem. Physiol., 49B, 393–406

    Google Scholar 

  71. Weekes, T. E. C. and Webster, A. J. F. (1975). Metabolism of propionate in the tissues of the sheep gut. Br. J. Nutr., 33, 425–438

    Article  CAS  Google Scholar 

  72. Weigand, E., Young, J. W. and McGilliard, A. D. (1972). Extent of propionate metabolism during absorption from the bovine rumino-reticulum. Biochem. J., 126, 201–209

    PubMed  CAS  Google Scholar 

  73. Whitehurst, G. B., Beitz, D. C., Pothoven, M. A., Ellison, R. and Crump, M. H. (1978). Lactate as a precursor of fatty acids in bovine adipose tissue. J. Nutr., 108, 1806–1811

    PubMed  CAS  Google Scholar 

  74. Williams, V. J. and Mackenzie, D. D. S. (1965). The absorption of lactic acid from the reticulo-rumen of the sheep. Aust. J. Biol. Sci., 18, 917–934

    PubMed  CAS  Google Scholar 

  75. Wirtz, A. and Bickhardt, K. (1977). Zum Ruhe-Lactatstoffwechsel bei nüchternen und gefütterten Schweinen. Z. Tierphysiol. Tierern. Futtermittelkd., 39, 146–156

    Article  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1980 MTP Press Limited

About this chapter

Cite this chapter

Giesecke, D., Stangassinger, M. (1980). Lactic acid metabolism. In: Ruckebusch, Y., Thivend, P. (eds) Digestive Physiology and Metabolism in Ruminants. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-8067-2_25

Download citation

  • DOI: https://doi.org/10.1007/978-94-011-8067-2_25

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-011-8069-6

  • Online ISBN: 978-94-011-8067-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics