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Mechanism(s) of action of nerve growth factor in intact and lethally injured sympathetic nerve cell in neonatal rodents

  • Chapter
Cell death in biology and pathology

Abstract

The central issue in the study of hormone-target cell interaction is to uncover the mechanism(s) of activation of the receptive cells by the ligand. Simultaneous progress along three different lines of hormone research provided new approaches to this problem. The first was the discovery of the second messenger, identified as the cyclic nucleotides, endowed with the property of transducing different hormonal signals in intracellular biochemical changes responsible for transient and longer-lasting physiological actions. The second was the recognition of the existence of membrane receptors, identified as macromolecules which selectively bind to different hormones and to neurotransmitters. These findings in turn sparked an ever-growing series of investigations directed towards the elucidation of the properties of the hormone-receptor complexes and of the mechanisms by which these complexes, once formed, modify the activities of specific membrane- localized enzymes, transport systems and intracellular events which follow the binding or internalization of these complexes in the target cells. The third was the finding that several polypeptides released in vivo by different organs and tissues, and in vitro by several normal and neoplastic cell lines, are endowed with a hormone-like activity on other cell types. Among these polypeptides, which became known as specific growth factors because of their main property of activating morphological and metabolic processes in cells at an early stage of their lifecycle, the most intensely investigated, as well as the first to have been discovered, is the Nerve Growth Factor (NGF). A unique and remarkable feature of this protein molecule, and one that is particularly relevant in this book devoted to the study of cell death, is that it elicits its potent growth and differentiative effects not only in its intact target cells, but also in the same cells that have been mortally injured by the most diversified treatments. In some but not all instances, evidence was obtained that death in the experimentally manipulated cells is directly related to experimental depletion of NGF, whether produced by immunological, chemical or surgical interventions.

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Authors
  1. Rita Levi-Montalcini
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  2. Luigi Aloe
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Editors and Affiliations

  1. Department of Zoology, University College, Cardiff, UK

    I. D. Bowen

  2. Department of Biological Sciences, St John’s University, New York, USA

    R. A. Lockshin

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© 1981 Chapman and Hall Ltd

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Levi-Montalcini, R., Aloe, L. (1981). Mechanism(s) of action of nerve growth factor in intact and lethally injured sympathetic nerve cell in neonatal rodents. In: Bowen, I.D., Lockshin, R.A. (eds) Cell death in biology and pathology. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-6921-9_11

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  • DOI: https://doi.org/10.1007/978-94-011-6921-9_11

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-011-6923-3

  • Online ISBN: 978-94-011-6921-9

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