Abstract
The peroxidative degradation of polyunsaturated fatty acids (I) involves (a) an initiating reaction leading to the formation of polyunsaturated fatty acid free radical (II); (b) subsequent reaction of II with oxygen to yield a peroxy radical (III); (c) reaction of III with another molecule of I to produce a hydroperoxide (IV) and a further molecule of II that can repeat the reaction with O2 as already described; (d) a variety of other reactions leading to the breakdown of the polyunsaturated fatty acid molecules, and chain terminations that inhibit the overall process of lipid peroxidation (for review see Tappel1). A simplified scheme showing initiation and propagation reactions is given in Figure 19.1.
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Slater, T.F. (1975). The role of lipid peroxidation in liver injury. In: Keppler, D. (eds) Pathogenesis and Mechanisms of Liver Cell Necrosis. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-6618-8_19
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DOI: https://doi.org/10.1007/978-94-011-6618-8_19
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