Abstract
The cells that I will describe are dying because blood flow has been interrupted: the left lateral and median liver lobes have been made ischaemic by clamping their blood vessels. According to the duration of the interruption of blood supply we can distinguish between: (1) Short- duration ischaemia, lasting 15–30 min and producing slight and easily reversible cellular damage. (2) Long-duration reversible ischaemia, lasting about 60 min and leading to severe but essentially reversible cell damage; no widespread necrosis occurs. (3) Long-duration irreversible ischaemia, lasting 120 min. The term irreversible does not refer to the interruption of the blood flow, which is re-established by removing the clamp after this time, but to the consequence to the tissue, where signs of widespread necrosis become evident later1.
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References
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© 1975 D. Keppler
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Bernelli-Zazzera, A. (1975). Ribosomes in dying liver cells. In: Keppler, D. (eds) Pathogenesis and Mechanisms of Liver Cell Necrosis. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-6618-8_10
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DOI: https://doi.org/10.1007/978-94-011-6618-8_10
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