Abstract
The development of vitamin A analogue compounds for use as therapeutic agents was mainly governed by the challenge to dissociate pharmacological effects from toxic side-effects, known as the hypervitaminosis A syndrome. According to groups of compounds with similar chemical structure within the general class of vitamin A analogues, Bollag1 discriminates three generations of retinoids: (1) chemically modified molecules of retinoic acid (including isomeric compounds), (2) retinoids, in which the β-Ionone ring of retinoic acid is exchanged by various other ring systems (e.g. aromatic rings), and (3) analogues with different forms of cyclizations particularly of the polyene side chain.
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Paravicini, U., Busslinger, A. (1984). Etretinate and Isotretinoin, Two Retinoids with Different Pharmacokinetic Profiles. In: Cunliffe, W.J., Miller, A.J. (eds) Retinoid Therapy. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-6349-1_2
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DOI: https://doi.org/10.1007/978-94-011-6349-1_2
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