Abstract
The development of renal dysfunction is frequent in critically ill patients W. Such renal dysfunction can manifest itself in the form of oliguria, refractory to fluid challenges, a rising serum creatinine concentration or both. Such critically ill patients typically have a number of mechanisms at work which may be responsible for the development of renal dysfunction. They include a recent history of hypotension or its presence, the occurrence of bleeding, severe sepsis, the systemic inflammatory syndrome, septic shock, a low cardiac output state, or the administration of nephrotoxins. In these patients, the pathogenesis of acute renal failure appears to be related to insufficient renal perfusion [2] with the development of medullary ischemia [3], and the activation of an exaggerated tubuloglomerular feedback.
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© 1998 Springer Science+Business Media Dordrecht
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Bellomo, R., Ronco, C. (1998). The use of inotropic and vasopressor agents in patients at risk of renal dysfunction. In: Critical Care Nephrology. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5482-6_95
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DOI: https://doi.org/10.1007/978-94-011-5482-6_95
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