Abstract
Here we examine the classical electron transfer chains of the mitochondrial respiratory oxidoreductase complexes. These chains guide electrons between substrates and energy coupling sites and between the coupling sites themselves. Structural studies on oxidoreductases are showing that several redox cofactors separated in protein by 4–10 Å are often in the form of a chain Long chains are evident in respiratory Complex I, II and in between Complexes III and IV. Calculations show that these chains are able to transfer electrons over very large distances with high directional specificity. Driven by small overall free energies, they operate in the microsecond time scale. Close proximity of the cofactors maintains physiologically productive rates even when substantial thermodynamically unfavorable steps are encountered in the chain. These steps offer potential points of regulation.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Moser, C.C., Keske, J.M., Warncke, K., Fand, R.S. and Dutton, P.L. (1992) Nature 355, 796–802.
Moser, C.C. and Dutton, P.L. (1992) Biochim. Biophys. Acta 1101, 171–176.
Michel, H., Deisenhofer, J. and Epp, O. (1986) EMBO Journal 5, 2445–2451.
Shopes, R.J., Holten, D., Levine, L. and Wraight, C.A. (1987) Photosynthesis Research 12, 165–180.
Ohnishi, T. and Salerno, J.C. (1982) Iron-Sulfur Proteins, Vol. 4, Wiley Publishing Co., New York
Beinert, H. and Albracht, S.P. (1982) Biochim. Biophys. Acta 683, 245–277.
Weiss, H., Friedrich, T., Hofhaus, G. and Preis, D. (1991) Eur. J. Biochem. 197, 563–576.
Walker, J.E. (1992) Q. Rev. Biophys. 25, 253–324.
Ohnishi, T. (1993) J. Bioener. Biomembr. 25, 325–330.
Yagi, T. (1993) Biochim. Biophys. Acta 1141, 1–17.
Fearnley, I.M. and Walker, J.E. (1992) Biochim. Biophys. Acta 1140, 105–134.
Leif, H., Sled, V.D., Ohnishi, T., Weiss, H. and Friedrich, T. (1995) Eur. J. Biochem. 230, 538–548.
Sled, V.D., Rudnitzky, N.I., Hatefi, Y. and Ohnishi, T. (1994) Biochemistry 33, 10069–10075.
Orme-Johnson, N.R., Hansen, R.E. and Beinert, H. (1974) J. Biol. Chem. 249, 1922–1927.
Beinert, IL and Palmer, G. (1965) Advances in Enzymology & Related Areas of Molecular Biology 27, 105–98.
Ackrell, B.A.C., Johnson, M.K., Gunsalus, R.P. and Ceccini, G. (1992) Chemistry and biochemistry of flavoenzymes, Vol. III, CRC Press, Boca Raton, Florida.
Hederstedt, L. and Ohnishi, T. (1992) Molecular Mechanisms in Bioenergetics, Elsevier Science Publishers, Amsterdam.
Salerno, J.C. and Ohnishi, T. (1980) Biochem. J. 192, 769–781.
Tukamiya, K. and Dutton, P.L. (1979) Biochim. Biophys. Acta 546, 1–16.
Gunner, M.R., Robertson, D.E. and Dutton, P.L. (1986) J. Phys. Chem. 90, 3783–3795.
Warncke, K. and Dutton, P.L. (1993) Biochemistry 32, 4769–4779.
Tsukihara, T. et al. (1995) Science 269, 1069–1074.
Tsukihara, T. et al. (1996) Science 272, 1136–1144.
Iwata, S., Ostermeier, C., Ludwig, B. and Michel, H. (1995) Nature 376, pp. 660–669.
Xia, D. et al. (1997) Science 277, 60–66.
Woodbury, N.W.T., et al. (1985) Biochim. Biophys. Acta 851, 6–22.
Volbeda, A., Charon, M.-H., Piras, C., Hatchikian, E.C., Frey, M. and Fontecilla-Camps, J.C. (1995) Nature 373, 580–587.
Krauss, N. et al (1993) Nature 361, 326–331.
Yu, L., Zhao, J., Lu, W., Bryant, D.A. and Golbeck, J.H. (1993) Biochemistry 32, 8251–8258.
Golbeck, J.H. and Bryant, D.A. (1991) Current Topics in Bioenergetics 16, 83–177.
Knaff, D.B. et al. (1991) Biochemistry 30, 1303–1310.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1998 Springer Science+Business Media Dordrecht
About this chapter
Cite this chapter
Dutton, P.L., Chen, X., Page, C.C., Huang, S., Ohnishi, T., Moser, C.C. (1998). Respiratory Electron Transfer Chains. In: Canters, G.W., Vijgenboom, E. (eds) Biological Electron Transfer Chains: Genetics, Composition and Mode of Operation. NATO ASI Series, vol 512. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5133-7_1
Download citation
DOI: https://doi.org/10.1007/978-94-011-5133-7_1
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-6158-2
Online ISBN: 978-94-011-5133-7
eBook Packages: Springer Book Archive