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Liver regeneration following partial hepatectomy: genes and metabolism

  • Chapter
Liver Growth and Repair

Abstract

The capacity of the liver to repair injury or restore partial loss is extraordinary — more so because the essential highly differentiated functions are maintained throughout the growth process, standing out as an exception to the often expressed view that growth and differentiation are mutually exclusive processes. The rat exceeds a whole range of species, including the mouse, in the rapidity of this so-called regeneration, a term almost universally used, and misleading since the excised lobes do not regrow. The regenerative process in the rat resembles the restoration in human liver closely enough to merit its continuing widespread investigation. New reviews include LaBrecque, 1991; Fausto and Webber, 1994; Russell and DuBois, 1994; Bucher, 1995; Michalopoulos, 1995.

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References

  • Alam, T., An, M.R. and Papaconstantinou, J. (1992) Differential expression of three C/EBP isoforms in multiple tissues during the acute phase response. Journal of Biological Chemistry, 267, 5021–5024.

    PubMed  CAS  Google Scholar 

  • Bach, P., Hamprecht, B. and Lynen, F. (1969) Regulation of cholesterol biosynthesis in rat liver: diurnal changes of activity and influence of bile acids. Archives of Biochemistry and Biophysics, 133, 11–21.

    Google Scholar 

  • Balle, C., Beuers, U., Engelhardt, R. and Jungermann, K. (1987) Intracellular mechanism of action of sympathetic hepatic nerves on glucose and lactate balance in perfused rat liver. European Journal of Biochemistry, 170, 193–199.

    PubMed  CAS  Google Scholar 

  • Barbiroli, B. and Potter, V. (1971) DNA synthesis and interaction between controlled feeding schedules and partial hepatectomy in rats. Science, 172, 738–740.

    PubMed  CAS  Google Scholar 

  • Barra, R. and Hall, J.C. (1977) Liver regeneration in normal and alloxan-induced diabetic rats. Journal of Experimental Zoology, 201, 93–100.

    PubMed  CAS  Google Scholar 

  • Bartles, J.R. and Hubbard, A.L. (1986) Preservation of hepatocyte plasma membrane domains during cell division in situ in regenerating rat liver. Developmental Biology, 118, 286–295.

    PubMed  CAS  Google Scholar 

  • Baumann, H., Morella, K.K., Campos, S.P. et al. (1992) Role of CAAT-enhancer binding protein isoforms in the cytokine regulation of acute-phase plasma protein genes. Journal of Biological Chemistry, 267, 19744–19751.

    PubMed  CAS  Google Scholar 

  • Ben Ze’ev, A., Robinson, G.S., Bucher, N.L.R. and Fanner, S.R. (1988) Cell-cell and cell-matrix interactions differentially regulate the expression of hepatic and cytoskeletal genes in primary cultures of adult rat hepatocytes. Proceedings of the National Academy of Sciences of the USA, 85, 2161–2165.

    PubMed  Google Scholar 

  • Beyer, H.S., Ellefson, M., Stanley, M. and Zieve, L. (1992) Inhibition of increases in ornithine decarboxylase and putrescine has no effect on rat liver regeneration. American Journal of Physiology, 262, G677–G684.

    PubMed  CAS  Google Scholar 

  • Birkenmeier, E.H., Gwynn, B., Howard, S. et al. (1989) Tissue-specific expression, developmental regulation, and genetic mapping of the gene encoding CCAAT/enhancer binding protein. Genes and Development, 3, 1146–1156.

    PubMed  CAS  Google Scholar 

  • Bissell, D.M., Arenson, D.M., Maher, JJ. and Roll, J. (1987) Support of cultured rat hepatocytes by a laminin-rich gel. Journal of Clinical Investigation, 79, 801–812.

    PubMed  CAS  Google Scholar 

  • Bissell, D.M., Wang, S.S., Jarnagin, W.N. and Roll, F.J. (1995) Cell-specific expression of transforming growth factor-beta in rat liver. Evidence for autocrine regulation of hepatocyte proliferation. Journal of Clinical Investigation, 96, 447–455.

    PubMed  CAS  Google Scholar 

  • Boyce, F.M. and Bucher, N.L.R. (1996) Baculovirus-mediated gene transfer into mammalian cells. Proceedings of the National Academy of Sciences of the USA, 93, 2348–2352.

    PubMed  CAS  Google Scholar 

  • Bronstad, G.O., Sand, T.E. and Christoffersen, T. (1983) Bidirectional concentrationdependent effects of glucagon and dibutyryl cyclic AMP and DNA synthesis in cultured adult rat hepatocytes. Biochimica et Biophysica Acta, 763, 58–63.

    PubMed  CAS  Google Scholar 

  • Brues, A.M., Drury, D.R. and Brues, M.C. (1936) A quantitative study of cell growth in regenerating liver. Archives of Pathology, 22, 658–673.

    CAS  Google Scholar 

  • Bucher N.L.R. (1977) Insulin, glucagon, and the liver. Advances in Enzyme Regulation, 15, 221–230.

    CAS  Google Scholar 

  • Bucher, N.L.R. (1991) Liver regeneration: an overview. Journal of Gastroenterology and Hepatology, 6, 615–624.

    PubMed  CAS  Google Scholar 

  • Bucher, N.L.R. (1995) Liver regneration then and now, in Liver Regeneration and Carcinogenesis (ed R.L. Jirtle), Academic Press, New York, pp. 1–25.

    Google Scholar 

  • Bucher, N.L.R. and Swaffield, M.N. (1964) The rate of incorporation of labeled thymidine into the deoxyribonucleic acid of regenerating rat liver in relation to the amount of liver excised. Cancer Research, 24, 1611–1625.

    PubMed  CAS  Google Scholar 

  • Bucher, N.L.R. and Oakman, N.J. (1969) Thymidine triphosphate content of regenerating rat liver. Biochimica et Biophysica Acta, 186, 13–20.

    PubMed  CAS  Google Scholar 

  • Bucher, N.L.R. and Swaffield, M.N. (1969) Ribonucleic acid synthesis in relation to precursor pools in regenerating rat liver. Biochimica et Biophysica Acta, 174, 491–501.

    PubMed  CAS  Google Scholar 

  • Bucher, N.L.R. and Swaffield, M.N. (1973) Regeneration of liver in rats in the absence of portal splanchnic organs and a portal blood supply. Cancer Research, 33, 3189–3194.

    PubMed  CAS  Google Scholar 

  • Bucher, N.L.R. and Swaffield, M.N. (1975) Regulation of hepatic regeneration in rats by synergistic action of insulin and glucagon. Proceeding of the National Academy of Sciences of the USA, 72, 1157–1160.

    CAS  Google Scholar 

  • Bucher, N.L.R. and Weir, G.C. (1976) Insulin, glucagon, liver regeneration and DNA synthesis. Metabolism, 25,(Suppl. 1), 1423–1425.

    PubMed  CAS  Google Scholar 

  • Bucher, N.L.R. and Strain, A.J. (1992) Regulatory mechanisms in hepatic regeneration, in Wright’s Liver and Biliary Disease, volume 3 (eds G.H. Millward-Salder, R. Wright and M.J.P. Arthur), Saunders, London, pp. 258–274.

    Google Scholar 

  • Bucher, N.L.R., Overath, P. and Lynen, F. (1960) Beta-hydroxy beta-methyl-glutaryl coenzyme A reductase, cleavage and condensing enzymes in relation to cholesterol fromation in rat liver. Biochimica et Biophysica Acta, 40, 491–501.

    PubMed  CAS  Google Scholar 

  • Bucher, N.L.R., Swaffield, M.N. and Ditroia, J.F. (1964) The influence of age upon the incorporation of thymidine-2-C14 into DNA of regenerating rat liver. Cancer Research, 24, 509–512.

    PubMed  CAS  Google Scholar 

  • Bucher, N.L.R., Schrock, T.R. and Moolten, F.L. (1969) An experimental view of hepatic regeneration. Johns Hopkins Medical Journal, 125, 250–257.

    PubMed  CAS  Google Scholar 

  • Bucher, N.L.R., McGowan, J.A. and Patel, U. (1978) Hormonal regulation of liver growth. ICN/ UCLA Symposia on Molecular and Cellular Biology, 12, 661–670.

    CAS  Google Scholar 

  • Bucher, N.L.R., Patel, U. and Cohen, S. (1978a) Hormonal factors and liver growth. Advances in Enzyme Regulation, 16, 205–213.

    CAS  Google Scholar 

  • Bucher, N.L.R., Patel, U. and Cohen, S. (1978b) Hormonal factors concerned with liver regeneration, in Hepatotrophic Factors: Ciba Foundation Symposium 55 (New Series). Elsevier/ Excerpta Medica/North Holland, New York, pp. 95–107.

    Google Scholar 

  • Bucher, N.L.R., Robinson, G.S. and Fanner, S.R. (1990) Effects of extracellular matrix on hepatocyte growth and gene expression: implications for hepatic regeneration and the repair of liver injury. Seminars in Liver Disease, 10, 11–19.

    PubMed  CAS  Google Scholar 

  • Cahill, G.F. (1973) Glucagon. New England Journal of Medicine, 288, 157–158.

    PubMed  Google Scholar 

  • Carr, B.I. (1989) Angiotensin II (Angio II) is a potent hepatocyte mitogen of liver origin. Hepatology, 10, 607 (abstract).

    Google Scholar 

  • Carr, B.I., Huang, T.H., Buzin, C.H. and Itakura, K. (1986) Induction of heat shock gene expression without heat shock by hepatocarcinogens and during hepatic regeneration in rat liver. Cancer Research, 46, 5106.

    PubMed  CAS  Google Scholar 

  • Carter, E.A., Kirkham, S.E., Tompkins, R.G. and Burke, J.F. (1989) Inhibition of in vivo DNA synthesis in regenerating rat liver following thermal injury. Biochemical and Biophysical Research Communications, 160, 196–201.

    PubMed  CAS  Google Scholar 

  • Caruana, J.A., Whalen, D.A. Jr, Anthony, W.P. et al. (1986) Paradoxical effects of glucose feeding on liver regeneration and survival after partial hepatectomy. Endocrine Research, 12, 147–156.

    PubMed  CAS  Google Scholar 

  • Castellano, T.J., Schiffman, R.L., Jacob, M.C. and Loeb, J.N. (1978) Suppression of liver cell proliferation by glucocorticoid hormone: a comparison of normally growing and regenerating tissue in the immature rat. Endocrinology, 102, 1107–1112.

    PubMed  CAS  Google Scholar 

  • Clarke, S.D. and Abraham, S. (1992) Gene expression: nutrient control of pre-and posttranscriptional events. FASEB Journal, 6, 3146–3152.

    PubMed  CAS  Google Scholar 

  • Clayton, D.F., Harrelson, A.L. and Darnell, J.R. (1985) Dependence of liver-specific transcription on tissue organization. Molecular and Cellular Biology, 5, 2623–2632.

    PubMed  CAS  Google Scholar 

  • Corlu, A., Ilyin, G.P., Gerard, N. et al. (1994) Tissue distribution of liver regulating protein. Evidence for a cell recognition signal common to liver, pancreas, gonads, and hemopoietic tissues. American Journal of Pathology, 145, 715–727.

    PubMed  CAS  Google Scholar 

  • Cross, S.M., Sanchez, C.A., Morgan, C.A. et al. (1995) A p53-dependent mouse spindle checkpoint. Science, 267, 1353–1356.

    PubMed  CAS  Google Scholar 

  • Cruise, J.L., Knechtle, S.J., Bollinger, R.R. et al. (1987) Alphal-adrenergic effects and liver regeneration. Hepatology, 7, 1189–1194.

    PubMed  CAS  Google Scholar 

  • Damsky, C.H. and Bernfield, M. (1991) Cell-to-cell contact and extracellular matrix. Current Opinion in Cell Biology, 5, 777–778.

    Google Scholar 

  • de Diego, J.A., Molina, L.M., Bujan, J. et al. (1986) Influence of the conjoint administration of insulin and glucagon upon hepatic regeneration. Surgery, Gynecology and Obstetrics, 163, 443–447.

    PubMed  Google Scholar 

  • Demetriou, A.A., Reisner, A., Sanchez, J. et al. (1988) Transplantation of microcarrier-attached hepatocytes into 90% partially hepatectomized rats. Hepatology, 8, 1006–1009.

    PubMed  CAS  Google Scholar 

  • Diehl, A.M. and Yang, S.Q. (1994) Regenerative changes in C/EBP alpha and C/EBP beta expression modulate binding to the C/EBP site in the c-fos promoter. Hepatology, 19, 447–456.

    PubMed  CAS  Google Scholar 

  • Diehl, A.M., Yang, S.Q., Yin M. et al. (1995) Tumor necrosis factor-alpha modulates CCAAT/ enhancer binding proteins — DNA binding activities and promotes hepatocyte-specific gene expression during liver regeneration. Hepatology, 22, 252–261.

    PubMed  CAS  Google Scholar 

  • DiPersio, C.M., Jackson, D.A. and Zaret, K.S. (1991) The extracellular matrix coordinately modulates liver transcription factors and hepatocyte morphology. Molecular and Cellular Biology, 11, 4405–4414.

    PubMed  CAS  Google Scholar 

  • Doljanski, F. (1960) The growth of the liver with special reference to mammals. International Review of Cytology, 10, 217–241.

    Google Scholar 

  • Ekberg, S., Luther, M., Nakamura, T. and Jansson, J.-O. (1992) Growth hormone promotes early initiation of hepatocyte growth factor gene expression in the liver of hypo-physectomized rats after partial hepatectomy. Journal of Endocrinology, 135, 59–67.

    PubMed  CAS  Google Scholar 

  • Etienne, P.L., Baffet, G., Desvergne, B. et al. (1988) Transient expression of c-fos and constant expression of c-myc in freshly isolated and cultured normal adult rat hepatocytes. Oncogene Research, 3, 255–262.

    PubMed  CAS  Google Scholar 

  • Fausto, N. and Webber, E.M. (1994) Liver regeneration, in The Liver: Biology and Pathobiology, volume 3 (eds I.M. Arias, J.L. Boyer, N. Fausto et al.), Raven Press, New York, pp. 1059–1084.

    Google Scholar 

  • Flaumenhaft, R. and Rifkin, D.B. (1992) The extracellullar regulation of growth factor action. Molecular Biology of the Cell, 3, 1057–1065.

    PubMed  CAS  Google Scholar 

  • Flodby, P., Antonson, P., Barlow, C. et al. (1993) Differential patterns of expression of three C/ EBP isoforms, HNF-1 and HNF-4 after partial hepatectomy in rats. Experimental Cell Research, 208, 248–256.

    PubMed  CAS  Google Scholar 

  • Friedman, J.M., Chung, E.Y. and Darnell, J.E. Jr (1984) Gene expression during liver regeneration. Journal of Molecular Biology, 179, 37–53.

    PubMed  CAS  Google Scholar 

  • Gaub, J. and Iversen, J. (1984) Rat liver regeneration after 90% partial hepatectomy. Hepatology, 4, 902–904.

    PubMed  CAS  Google Scholar 

  • Goldsworthy, T.L., Goldsworthy, S.M., Sprankle, C.S. and Butterworth, B.E. (1994) Expres-sion of myc, fos and Ha-ras associated with chemically induced cell proliferation in the rat liver. Cell Proliferation, 27, 269–278.

    PubMed  CAS  Google Scholar 

  • Gudas, J.M., Fridovich-Keil, J.L. and Pardee, A.B. (1993) Posttranscriptional control of thymidine kinase messenger RNA accumulation in cells released from G0-G1 phase blocks. Cell Growth and Differentiation, 4, 421–430.

    PubMed  CAS  Google Scholar 

  • Gumucio, J.J., Bilir, B.M., Moseley, R.H. and Berkowitz, C.M. (1994) The biology of the liver cell plate, in The Liver: Biology and Pathobiology, volume 3 (eds I.M. Arias, J.L. Boyer, N. Fausto et al.), Raven Press, New York, pp. 1143–1163.

    Google Scholar 

  • Haber, B.A., Chin S., Chuang, E. et al. (1995) High levels of glucose-6-phosphatase gene and protein expression reflect an adaptive response in proliferating liver and diabetes. Journal of Clinical Investigation, 95, 832–841.

    PubMed  CAS  Google Scholar 

  • Hansen, L.K., Mooney, D.J., Vacanti, J.P. and Ingber, D.E. (1994) Integrin binding and cell spreading on extracellular matrix act at different points in the cell cycle to promote hepatocyte growth. Molecular Biology of the Cell, 5, 967–975.

    PubMed  CAS  Google Scholar 

  • Hartwell, L.H. and Weinert, T.A. (1989) Checkpoints: controls that ensure the order of cell cycle events. Science, 246, 629–634.

    PubMed  CAS  Google Scholar 

  • Hasegawa, K., Kar, S. and Carr, B.I. (1994) Stimulation of hepatocyte DNA synthesis by neurotensin. Journal of Cellular Physiology, 158, 215–222.

    PubMed  CAS  Google Scholar 

  • Hattori, M., Tugores, A., Westwick, J.K. et al. (1993) Activation of activating protein 1 during hepatic acute phase response. American Journal of Physiology, 264, G95–G103.

    PubMed  CAS  Google Scholar 

  • Higgins, G.M. and Anderson, R.M. (1931) Experimental pathology of the liver I: restoration of the liver of the white rat following partial surgical removal. Archives of Pathology, 12, 186–202.

    Google Scholar 

  • Hirvonen, A. (1989) Ornithine decarboxylase activity and the accumulation of its mRNA during early stages of liver regeneration. Biochimica et Biophysica Acta, 1007, 120–123.

    PubMed  CAS  Google Scholar 

  • Holecek, M., Simek, J., Palicka, V. and Zadak, Z. (1991) Effect of glucose and branched chain amino acid (BCAA) infusion on onset of liver regeneration and plasma amino acid pattern in partially hepatectomized rats. Journal of Hepatology, 13, 14–20.

    PubMed  CAS  Google Scholar 

  • Horikawa, S., Sakata, K., Hatanaka, M. and Tsukada, K. (1986) Expressionof c-myc oncogene in rat liver by dietary manipulation. Biochemical and Biophysical Research Communications, 140, 574–580.

    CAS  Google Scholar 

  • Ingle, D.J. and Baker, B.L. (1957) Histology and regenerative capacity of liver following multiple partial hepatectomies. Proceedings of the Society for Experimental Biology and Medicine, 95, 813–815.

    PubMed  CAS  Google Scholar 

  • Ismail, T., Howl, J., Wheatley, M. et al. (1991) Growth of normal human hepatocytes in primary culture: effect of hormones and growth factors on DNA synthesis. Hepatology, 14, 1076–1082.

    PubMed  CAS  Google Scholar 

  • Jungermann, K. (1988) Metabolic zonation of liver parenchyma. Seminars in Liver Disease, 8, 329–341.

    PubMed  CAS  Google Scholar 

  • Keppens, S., Van der Kerckhove, A., Moshage, H. et al. (1993) Regulation of glycogen phosphorlyase activity in isolated human hepatocytes. Hepatology, 17, 610–614.

    PubMed  CAS  Google Scholar 

  • Kleinman, H.K., McGarvey, M.L., Hassell, J.R. et al. (1986) Basement membrane complexes with biological activity. Biochemistry, 25, 312–318.

    PubMed  CAS  Google Scholar 

  • Klinge, O. and Mathyl, J. (1969) Diurnal mitotic rhythms in the rat liver after partial hepatectomy. Virchows Archiv B, Cell Pathology, 2, 154–162.

    CAS  Google Scholar 

  • Koch, K.S. and Leffert, H.L. (1979) Increased sodium ion influx is necessary to initiate rate of hepatocyte proliferation. Cell, 18, 153–163.

    PubMed  CAS  Google Scholar 

  • Koff, A., Ohtsuki, M., Polyak, K. et al. (1993) Negative regulation of G1 in mammalian cells: inhibition of cyclin E-dependent kinase by TGF-beta. Science, 260, 536–539.

    PubMed  CAS  Google Scholar 

  • Kost, D.P. and Michalopoulos, G.K. (1990) Effect of epidermal growth factor on the expression of protooncogenes c-myc and c-Ha-ras in short term primary hepatocyte culture. Journal of Cellular Physiology, 144, 122–127.

    PubMed  CAS  Google Scholar 

  • Labow, R., Maley, G.F. and Maley, F. (1969) Effect of methotrexate on enzymes induced following partial hepatectomy. Cancer Research, 29, 366–372.

    PubMed  CAS  Google Scholar 

  • LaBrecque, D.R. (1991) Hepatic stimulator substance. Discovery, characteristics and mechanism of action. Digestive Diseases and Sciences, 36, 669–673.

    PubMed  CAS  Google Scholar 

  • Leduc, E. (1949) Mitotic activity in the liver of the mouse during inanition followed by refeeding with different levels of protein. American Journal of Anatomy, 84, 397–430.

    PubMed  CAS  Google Scholar 

  • Liu, M.L., Mars, W.M., Zarnegar, R. and Michalopoulos, G.K. (1994) Collagenase pretreatment and the mitogenic effects of hepatocyte growth factor and transforming growth factor-alpha in adult rat liver. Hepatology, 19, 1521–1527.

    PubMed  CAS  Google Scholar 

  • Loreal, O., Levavasseur, F., Fromaget, C. et al. (1993) Cooperation of Ito cells and hepatocytes in the deposition of an extracellular matrix in vitro. American Journal of Pathology, 143, 538–544.

    PubMed  CAS  Google Scholar 

  • Loyer, P., Glaise, D., Cariou, S. et al. (1994) Expression and activation of cdks (1 and 2) and cyclins in the cell cycle progression during liver regeneration. Journal of Biological Chemistry, 269, 2491–2500.

    PubMed  CAS  Google Scholar 

  • McGowan, J., Atryzek, V. and Fausto, N. (1979) Effects of protein-deprivation on the regeneration of rat liver after partial hepatectomy. Biochemical Journal, 180, 25–35.

    PubMed  CAS  Google Scholar 

  • McGowan, J.A., Strain, A.J. and Bucher, N.L.R. (1981) DNA synthesis in primary cultures of adult rat hepatocytes in a defined medium: effects of epidermal growth factor, insulin, glucagon, and cyclic AMP. Journal of Cellular Physiology, 108, 353–363.

    PubMed  CAS  Google Scholar 

  • McKnight, S.L., Lane, M.D. and Gluecksohn-Waelsch, S. (1989) Is CCATT/enhancer-binding protein a central regulator of energy metabolism? Genes and Development, 3, 2021–2024.

    PubMed  CAS  Google Scholar 

  • MacManus, J.P., Braceland, B.M., Youdale, T. and Whitfield, J.F. (1973) Adrenergic antagonists, and a possible link between the increase in cyclic adenosine 3′,5′-monophosphate and DNA synthesis during liver regeneration. Journal of Cellular Physiology, 82, 157–164.

    PubMed  CAS  Google Scholar 

  • Matsumoto, K. and Nakamura, T. (1992) Hepatocyte growth factor: molecular structure, roles in liver regeneration, and other biological functions. Critical Reviews in Oncogenesis, 3, 27–54.

    PubMed  CAS  Google Scholar 

  • Mead, J.E., Braun, L., Martin, D.A. and Fausto, N. (1990) Induction of replicative competence (‘priming’) in normal liver. Cancer Research, 50, 7023–7030.

    PubMed  CAS  Google Scholar 

  • Mesnil, M., Fraslin, J., Piccoli, C. et al. (1987) Cell contact but not junctional communication (dye coupling) with biliary epithelial cells is required for hepatocytes to maintain differentiated functions. Experimental Cell Research, 173, 524–533.

    PubMed  CAS  Google Scholar 

  • Metz, R. and Ziff, E. (1991) cAMP stimulates the C/EBP-related transcription factor rNFIL-6 to translocate to the nucleus and induce c-fos transcription. Genes and Development, 5, 1754–1766.

    PubMed  CAS  Google Scholar 

  • Michalopoulos, G.K. (1990) Liver regeneration: molecular mechanisms of growth control. FASEB Journal, 4, 176–187.

    PubMed  CAS  Google Scholar 

  • Michalopoulos, G.K. (1995) Hepatocyte growth factor (HGF) and its receptor (MET) in liver regeneration, neoplasia, and disease, in Liver Regeneration and Carcinogenesis (ed R.L. Jirtle), Academic Press, New York, pp. 27–49.

    Google Scholar 

  • Milland, J., Tsykin, A., Thomas, T. et al. (1990) Gene expression in regenerating and acutephase rat liver. American Journal of Physiology, 259, G340–G347.

    PubMed  CAS  Google Scholar 

  • Mischoulon, D., Rana, B., Bucher, N.L.R. and Farmer, S.R. (1992) Growth-dependent inhibition of CCAAT enhancer-binding protein (C/EBP alpha) gene expression during hepatocyte proliferation in the regenerating liver and in culture. Molecular and Cellular Biology, 12, 2553–2559.

    PubMed  CAS  Google Scholar 

  • Mohn, K.L., Laz., T.M., Melby, A.E. and Taub, R. (1990) Immediate-early gene expression differs between regenerating liver, insulin-stimulated H-35 cells, and mitogen-stimulated Balb/e 3T3 cells. Journal of Biological Chemistry, 265, 21914–21921.

    PubMed  CAS  Google Scholar 

  • Moolten, F.L., Oakman, N.L. and Bucher, N.L.R. (1970) Accelerated response of hepatic DNA synthesis to partial hepatectomy in rats pre-treated with growth hormone or surgical stress. Cancer Research, 30, 2353–2357.

    PubMed  CAS  Google Scholar 

  • Mooney, D., Hansen, L., Vacanti, J. et al. (1992) Switching from differentiation to growth in hepatocytes: control by extracellular matrix. Journal of Cellular Physiology, 151, 497–505.

    PubMed  CAS  Google Scholar 

  • Morley, C.G.D., Kuku, S., Rubenstein, A.H. and Boyer, J.L. (1975) Serum hormone levels following partial hepatectomy in the rat. Biochemical and Biophysical Research Communications, 67, 653–661.

    PubMed  CAS  Google Scholar 

  • Ohmori, H., Murakami, T., Furutani, A. et al. (1990) Simultaneous activation of heat shock protein (hsp70) and nucleolin genes during in vivo and in vitro prereplicative stages of rat hepatocytes. Experimental Cell Research, 189, 227–232.

    PubMed  CAS  Google Scholar 

  • Pardee, A.B. (1989) G1 events and regulation of cell proliferation. Science, 246, 603–608.

    PubMed  CAS  Google Scholar 

  • Pardee, A.B. (1994) Multiple molecular levels of cell cycle regulation. Journal of Biological Chemistry, 54, 375–378.

    CAS  Google Scholar 

  • Park, E.A., Gurney, A.L., Nizielski, S.E. et al. (1993) Relative roles of CCAAT/enhancer-binding protein beta and cAMP regulatory element-binding protein in controlling transcription of the gene for phosphoenolpyruvate carboxykinase (GTP). Journal of Biological Chemistry, 268, 613–619.

    PubMed  CAS  Google Scholar 

  • Pledger, W.J., Stiles, C.D., Antoniades, H.N. and Scher, C.D. (1977) Induction of DNA synthesis in Balb/c 3T3 cells by serum components: reevaluation of the commitment process. Proceedings of the National Academy of Sciences of the USA, 74, 4481–4485.

    PubMed  CAS  Google Scholar 

  • Poso, H. and Pegg, A.E. (1982) Effect of alpha-difluoromethylornithine on polyamine and DNA synthesis in regenerating rat liver. Biochimica et Biophysica Acta, 696, 179–186.

    PubMed  CAS  Google Scholar 

  • Rana, B., Mischoulon D., Xie, Y. et al. (1994) Cell-extracellular matrix interactions can regulate the switch between growth and differentiation in rat hepatocytes: reciprocal expression of C/EBP alpha and immediate-early growth response transcription factors. Molecular and Cellular Biology, 14, 5858–5869.

    PubMed  CAS  Google Scholar 

  • Rana, B., Xie, Y., Mischoulon, D. et al. (1995) The DNA binding activity of C/EBP transcription factors is regulated in the G1 phase of the hepatocyte cell cycle. Journal of Biological Chemistry, 270, 18123–18132.

    PubMed  CAS  Google Scholar 

  • Richman, R.A., Claus, T.A., Pilkis, S.J. and Friedman, D.L. (1976) Hormonal stimulation of DNA synthesis in primary cultures of adult rat hepatocytes. Proceedings of the National Academy of Sciences of the USA, 73, 3589–3593.

    PubMed  CAS  Google Scholar 

  • Rojkind, M., Novikoff, P.M., Greenwel, P. et al. (1995) Characterization and functional studies on rat liver fat-storing cell line and freshly isolated hepatocyte coculture system. American Journal of Pathology, 146, 1508–1520.

    PubMed  CAS  Google Scholar 

  • Russell, W.E. and Bucher, N.L.R. (1983) Vasopressin modulates liver regeneration in the Brattleboro rat. American Journal of Physiology, 245, G321–G324.

    PubMed  CAS  Google Scholar 

  • Russell, W.E. and DuBois, R.N. (1994) The regulation of liver growth and regeneration, in Liver Disease in Children (ed F.J. Suchy), Mosby Year Book Inc., St Louis, Missouri, pp. 11–30.

    Google Scholar 

  • Russell, W.E., McGowan, J.A. and Bucher, N.L.R. (1984) Partial characterization of a hepatocyte growth factor from rat platelets. Journal of Cellular Physiology, 119, 183–192.

    PubMed  CAS  Google Scholar 

  • Russell, W.E., Coffey, J.R., Ouellette, A.J. and Moses, H.L. (1988) Type beta transforming growth factor reversibly inhibits the early proliferative response to partial hepatectomy in the rat. Proceedings of the National Academy of Sciences of the USA, 85, 5126–5130.

    PubMed  CAS  Google Scholar 

  • Scher, C.D., Shepard, R.C., Antoniades, H.N. and Stiles, C.D. (1979) Platelet-derived growth factor and the regulation of the mammalian fibroblast cell cycle. Biochimica et Biophysica Acta, 560, 217–241.

    PubMed  CAS  Google Scholar 

  • Schlesinger, M.J. (1990) Heat shock proteins. Journal of Biological Chemistry, 265, 12111–12114.

    PubMed  CAS  Google Scholar 

  • Schrock, T.R., Oakman, N.J. and Bucher, N.L.R. (1970) Ornithine decarboxylase activity in relation to growth of rat liver; effects of partial hepatectomy, hypertonic infusions, celite injection or other stressful procedures. Biochimica et Biophysica Acta, 204, 564–577.

    PubMed  CAS  Google Scholar 

  • Schulte-Hermann, R. (1977) Two stage control of cell proliferation induced in rat liver by alpha-hexachlorocyclohexane. Cancer Research, 37, 166–171.

    PubMed  CAS  Google Scholar 

  • Schulte-Hermann, R., Grasl-Kraupp, B. and Bursch, W. (1995) Apoptosis and hepato-carcinogenesis, in Liver Regeneration and Carcinogenesis (ed R.L. Jirtle), Academic Press, New York, pp. 141–178.

    Google Scholar 

  • Sherr, C.J. (1994) G1 phase progression: cycling on cue. Cell, 79, 551–555.

    PubMed  CAS  Google Scholar 

  • Simek, J., Erbenova, Z., Deml, F. and Dvorackova, I. (1968a) Liver regeneration after partial hepatectomy in rats exposed before the operation to the stress stimulus. Experientia, 24, 1166–1167.

    PubMed  CAS  Google Scholar 

  • Simek, J., Husakova, A., Erbenova, Z. and Kanta, J. (1968b) The role of the adrenals in changes of liver triglycerides content after partial hepatectomy in rats of different ages. Physiologia Bohemoslovaca, 17, 563–567.

    PubMed  CAS  Google Scholar 

  • Simpson, G.E.C. and Finckh, E.S. (1963) Pattern of regeneration of rat liver after repeated partial hepatectomies. Journal of Pathology and Bacteriology, 86, 361–370.

    PubMed  CAS  Google Scholar 

  • Sporn, M.B. and Roberts, A.B. (1988) Peptide growth factors are multifunctional. Nature, 332, 217–219.

    PubMed  CAS  Google Scholar 

  • Starzl, T.E. and Terblanche, J. (1979) Hepatotrophic substances. Progress in Liver Disease, 6, 135–151.

    CAS  Google Scholar 

  • Starzl, T.E. (1980) The ripple effect of liver transplantation. Transplantation Proceedings, XII, 626–633.

    Google Scholar 

  • Steiner, D.F. (1978) Insulin-induced liver hyperplasia: evidence for a negative liver-size-correcting process, in Hepatotrophic Factors: Ciba Foundation Symposium 55 (New Series). Elsevier/Excerpta Medica/North Holland, New York, pp. 229–246.

    Google Scholar 

  • Stocker, E., Schultze, B., Heine, W.-D. and Liebscher, H. (1972) Wachstum und Regeneration in parenchymatosen Organen der Ratte. Zeitschrift fur Zellforschung und Mikroskopische Anatomie, 125, 306–331.

    PubMed  CAS  Google Scholar 

  • Strain, A.J. (1988) Transforming growth factor-beta and inhibition of hepatocellular proliferation. Scandinavian Journal of Gastroenterology, 23,(Suppl. 151), 37–45.

    Google Scholar 

  • Strain, A.J., McGowan, J.A. and Bucher, N.L.R. (1982) Stimulation of DNA synthesis in primary cultures of adult rat hepatocytes by rat platelet-associated substance(s). In Vitro, 18, 106–116.

    Google Scholar 

  • Takatsuki, K., Fujiwara, K., Hayashi, S. et al. (1981) Acceleration of DNA synthesis in post-hepatectomised regenerating liver of normal rat by insulin and glucagon. Life Sciences, 29, 2609–2615.

    PubMed  CAS  Google Scholar 

  • Tashiro, K., Hagiya, M., Nishizawa, T. et al. (1990) Deduced primary structure of rat hepatocyte growth factor and expression of the mRNA in rat tissues. Proceedings of the National Academy of Sciences of the USA, 87, 3200–3204.

    PubMed  CAS  Google Scholar 

  • Taub, R. (1995) Expression and function of growth-induced genes during liver regeneration, in Liver Regeneration and Carcinogenesis (ed R.L. Jirtle), Academic Press, New York, pp. 71–97.

    Google Scholar 

  • Terpstra, O.T., Malt, R.A. and Bucher, N.L.R. (1979) Negligible role of adrenal hormones in regulation of DNA synthesis in livers of partially hepatectomized rats (40546). Proceedings of the Society for Experimental Biology and Medicine, 161, 326–331.

    PubMed  CAS  Google Scholar 

  • Umek, R.M., Friedman, A.D. and McKnight, S.L. (1991) CCAAT-enhancer binding protein: a component of a differentiation switch. Science, 251, 288–292.

    PubMed  CAS  Google Scholar 

  • van Ooij, C., Snyder, R.C., Paeper, B.W. and Duester, G. (1992) ADH, 2 and 3: genes whose times have come. Molecular and Cellular Biology, 12, 3023–3031.

    PubMed  Google Scholar 

  • Wagle, S.R. and Sampson, L. (1975) Studies on the differential response to insulin on the stimulation of amino acid incorporation into protein in isolated hepatocytes containing different levels of glycogen. Biochemical and Biophysical Research Communications, 64, 72–80.

    PubMed  CAS  Google Scholar 

  • Wang, N., Finegold, M.J., Bradley, A. et al. (1995) Impaired energy homeostasis in C/EBP alpha knockout mice. Science, 269, 1108–1112.

    PubMed  CAS  Google Scholar 

  • Webber, E.M., Godowski, P.J. and Fausto, N. (1994) In vivo response of hepatocytes to growth factors requires an initial priming stimulus. Hepatology, 14, 489–497.

    Google Scholar 

  • Whitfield, J.F., Durkin, J.P., Franks, D.J. et al. (1987) Calcium, cyclic AMP and protein kinase C — partners in mitogenesis. Cancer and Metastasis Reviews, 5, 205–250.

    PubMed  CAS  Google Scholar 

  • Whittemore, A.D., Kasuya, M., Voorhees, A.B. Jr and Price, J.B. Jr (1975) Hepatic regeneration in the absence of portal viscera. Surgery, 77, 419–426.

    PubMed  CAS  Google Scholar 

  • Williamson, J.R., Cooper, R.H., Joseph, S.K. and Thomas, A.P. (1985) Inositol trisphosphate and diacylglycerol as intracellular second messengers in liver. American Journal of Physiology, 248, C203–C216.

    PubMed  CAS  Google Scholar 

  • Younger, L.R., King, J. and Steiner, J.E. (1966) Hepatic proliferation response to insulin in severe alloxan diabetes. Cancer Research, 26, 1408–1414.

    PubMed  CAS  Google Scholar 

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  1. Boston University School of Medicine Boston, Massachusetts, USA

    Nancy L. R. Bucher & Stephen R. Farmer

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Alastair Strain Anne Mae Diehl

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Bucher, N.L.R., Farmer, S.R. (1998). Liver regeneration following partial hepatectomy: genes and metabolism. In: Strain, A., Diehl, A.M. (eds) Liver Growth and Repair. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-4932-7_1

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