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Th1/Th2 lymphocyte responses in Helicobacter infections

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Helicobacter pylori

Abstract

Although virtually everyone who is infected with Helicobacter pylori will display chronic active gastritis, such people are generally free of other symptoms, and only a minority of infected individuals develop more severe disease and overt symptoms. This has been ascribed both to differences among bacterial isolates, most notably in the cag pathogenicity island1, for which CagA is a marker, and to differences in the host response to infection2,3. Interaction of the bacteria with gastric epithelial cells leads to epithelial secretion of interleukin 6 (IL-6), IL-8, and other innate mediators which are important in recruiting neutrophils to the gastric compartment4–6. The presence of significant numbers of lymphocytes in the inflamed gastric tissue of H. pylori-infected individuals suggests that the adaptive immune response may also contribute to Helicobacter-associated gastritis.

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Authors
  1. J. G. Nedrud
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  2. M. Mohammadi
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  3. T. Blanchard
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  4. R. Redline
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  5. S. J. Czinn
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Editor information

Editors and Affiliations

  1. Division of Gastroenterology, McMaster University Medical Centre, 1200 Main Street West, Hamilton, Ontario, L8N 3Z5, Canada

    Richard H. Hunt (Professor of Medicine, Director) (Professor of Medicine, Director)

  2. Department of Gastroenterology and Hepatology, Academic Medical Centre, 9 Meibergdreef, 1105 AZ, Amsterdam, The Netherlands

    Guido N. J. Tytgat (Professor) (Professor)

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© 1998 Springer Science+Business Media Dordrecht

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Nedrud, J.G., Mohammadi, M., Blanchard, T., Redline, R., Czinn, S.J. (1998). Th1/Th2 lymphocyte responses in Helicobacter infections. In: Hunt, R.H., Tytgat, G.N.J. (eds) Helicobacter pylori. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-4882-5_13

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  • DOI: https://doi.org/10.1007/978-94-011-4882-5_13

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6046-2

  • Online ISBN: 978-94-011-4882-5

  • eBook Packages: Springer Book Archive

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